vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»vsp-1018Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESЭФФЕКТИВНОСТЬ РАЗЛИЧНЫХ РЕЖИМОВ ИММУНОСУПРЕССИВНОЙ ТЕРАПИИ ЦИКЛОСПОРИНОМ И МЕТОТРЕКСАТОМ У БОЛЬНЫХ СИСТЕМНЫМ ВАРИАНТОМ ЮВЕНИЛЬНОГО РЕВМАТОИДНОГО АРТРИТАEFFICACY OF DIFFERENT IMMUNOSUPPRESSIVE PROTOCOLS WITH CYCLOSPORINE AND METHOTREXATE FOR PATIENTS WITH SYSTEMIC VARIANT OF JUVENILE RHEUMATOID ARTHRITISАлексееваЕ.И.AlexeevaE.I.ВалиеваС.И.ValievaS.I.АпаеваД.В.ApaevaD.V.Научный центр здоровья детей РАМН, МоскваРоссияScientific center of children health, Russian Academy of Medical Sciences, MoscowRussian Federation20071709201562Вопросы современной педиатрии2934Copyright © Алексеева Е., Валиева С., Апаева Д., 20072007Алексеева Е., Валиева С., Апаева Д.Alexeeva E., Valieva S., Apaeva D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1018ReferencesCassidy J.T., Petty R.E. Textbook of pediatrie rheumatology II. New York: Churchill Livingstone. 2002.Cassidy J.T., Petty R.E. Textbook of pediatrie rheumatology II. New York: Churchill Livingstone. 2002.Шахбазян И.Е. Ювенильный ревматоидный артрит — суставно–висцеральная форма. Педиатрия. 1983; 11: 28–31.Шахбазян И.Е. Ювенильный ревматоидный артрит — суставно–висцеральная форма. Педиатрия. 1983; 11: 28–31.Blumenauer B., Cranney A., Clinch J. et al. Quality of life in patients with rheumatoid arthritis: which drugs might make a difference? Pharmacoeconomics. 2003; 21 (13): 927–940.Blumenauer B., Cranney A., Clinch J. et al. Quality of life in patients with rheumatoid arthritis: which drugs might make a difference? Pharmacoeconomics. 2003; 21 (13): 927–940.Pincus T., Ferraccioli G., Sokka T. et al. Evidence from clinical trials and long term observational studies that disease modifying anti rheumatic drugs slow radiographic progression in rheumatoid arthritis: updating a 1983 review. Rheumatol. (Oxford). 2002; 41 (12): 1346–1356.Pincus T., Ferraccioli G., Sokka T. et al. Evidence from clinical trials and long term observational studies that disease modifying anti rheumatic drugs slow radiographic progression in rheumatoid arthritis: updating a 1983 review. Rheumatol. (Oxford). 2002; 41 (12): 1346–1356.Guthrie B., Rouster-Stevens K.A., Reynolds S.L. Review of medications used in juvenile rheumatoid arthritis. Pediatr. Emerg. Care V. 2007; 23 (1): 38–46.Guthrie B., Rouster-Stevens K.A., Reynolds S.L. Review of medications used in juvenile rheumatoid arthritis. Pediatr. Emerg. Care V. 2007; 23 (1): 38–46.Wallace C.A. Current management of juvenile idiopathic arthritis. Best. Pract. Res. Clin. Rheumatol. 2006; 20 (2): 279–300.Wallace C.A. Current management of juvenile idiopathic arthritis. Best. Pract. Res. Clin. Rheumatol. 2006; 20 (2): 279–300.Алексеева Е.И., Шахбазян И.Е. Принципы патогенетической терапии тяжёлых системных вариантов ювенильного ревматоидного артрита. Серия Аутоиммунные болезни № 5. М. 2002. 127 с.Алексеева Е.И., Шахбазян И.Е. Принципы патогенетической терапии тяжёлых системных вариантов ювенильного ревматоидного артрита. Серия Аутоиммунные болезни № 5. М. 2002. 127 с.Hashkes P.J., Laxer R.M. Medical treatment of juvenile idiopathic arthritis. JAMA. 2005; 294 (13): 1671–1684.Hashkes P.J., Laxer R.M. Medical treatment of juvenile idiopathic arthritis. JAMA. 2005; 294 (13): 1671–1684.Woo P., Southwood T.R., Prieur A.M. et al. Randomized, placebo controlled, crossover trial of low dose oral methotrexate in children with extended oligoarticular or systemic arthritis. Arthr. Rheum. 2000; 43 (8): 1849–1857.Woo P., Southwood T.R., Prieur A.M. et al. Randomized, placebo controlled, crossover trial of low dose oral methotrexate in children with extended oligoarticular or systemic arthritis. Arthr. Rheum. 2000; 43 (8): 1849–1857.Chikanza I.C. Juvenile rheumatoid arthritis: therapeutic perspectives. Paediatr. Drugs. 2002; 4 (5): 335–348.Chikanza I.C. Juvenile rheumatoid arthritis: therapeutic perspectives. Paediatr. Drugs. 2002; 4 (5): 335–348.Reiff A., Shaham B., Wood B.P. et al. High dose methotrexate in the treatment of refractory juvenile rheumatoid arthritis. Clin. Exp. Rheumatol. 1995; 13 (1): 113–118.Reiff A., Shaham B., Wood B.P. et al. High dose methotrexate in the treatment of refractory juvenile rheumatoid arthritis. Clin. Exp. Rheumatol. 1995; 13 (1): 113–118.TambicCBukovac L., Malcic I., Prohic A. Personal experience with methotrexate in the treatment of idiopathic juvenile arthritis. Rheumatism. 2002; 49 (1): 20–24.TambicCBukovac L., Malcic I., Prohic A. Personal experience with methotrexate in the treatment of idiopathic juvenile arthritis. Rheumatism. 2002; 49 (1): 20–24.Papadopoulos N.G., Alamanos Y., Papadopoulos I.A. et al. Disease modifying antirheumatic drugs in early rheumatoid arthritis: a long term observational study. J. Rheumatol. 2002; 29 (2): 261–266.Papadopoulos N.G., Alamanos Y., Papadopoulos I.A. et al. Disease modifying antirheumatic drugs in early rheumatoid arthritis: a long term observational study. J. Rheumatol. 2002; 29 (2): 261–266.Aletaha D., Smolen J.S. The rheumatoid arthritis patient in the clinic: comparing more than 1,300 consecutive DMARD courses. Rheumatology (Oxford). 2002; 41 (12): 1367–1374.Aletaha D., Smolen J.S. The rheumatoid arthritis patient in the clinic: comparing more than 1,300 consecutive DMARD courses. Rheumatology (Oxford). 2002; 41 (12): 1367–1374.Алексеева Е.И., Шахбазян И.Е. Сандиммун–Неорал — новое качество жизни для больных с тяжёлым системным ювенильным ревматоидным артритом. Терапевтический архив. 1999; 71 (5): 26–29.Алексеева Е.И., Шахбазян И.Е. Сандиммун–Неорал — новое качество жизни для больных с тяжёлым системным ювенильным ревматоидным артритом. Терапевтический архив. 1999; 71 (5): 26–29.Gerloni V., Cimaz R., Gattinara M. et al. Efficacy and safety profile of cyclosporin A in the treatment of juvenile chronic (idiopathic) arthritis. Results of a 10 year prospective study. Rheumatol. (Oxford). 2001; 40 (8): 907–913.Gerloni V., Cimaz R., Gattinara M. et al. Efficacy and safety profile of cyclosporin A in the treatment of juvenile chronic (idiopathic) arthritis. Results of a 10 year prospective study. Rheumatol. (Oxford). 2001; 40 (8): 907–913.Drosos A.A., Voulgari P.V., Katsaraki A. et al. Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42 month prospective study. Rheumatol. Int. 2000; 19 (3): 113–118.Drosos A.A., Voulgari P.V., Katsaraki A. et al. Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42 month prospective study. Rheumatol. Int. 2000; 19 (3): 113–118.Tanaka Y., Tsujimura S. Clinical implication of cyclosporin for rheumatoid arthritis. Nippon Rinsho. 2002; 60 (12): 2345–2350.Tanaka Y., Tsujimura S. Clinical implication of cyclosporin for rheumatoid arthritis. Nippon Rinsho. 2002; 60 (12): 2345–2350.Drosos A.A., Voulgari P.V., Papadopoulos I.A. et al. Cyclosporine A in the treatment of early rheumatoid arthritis. A prospective, randomized 24 month study. Clin. Exp. Rheumatol. 1998; 16 (6): 695–701.Drosos A.A., Voulgari P.V., Papadopoulos I.A. et al. Cyclosporine A in the treatment of early rheumatoid arthritis. A prospective, randomized 24 month study. Clin. Exp. Rheumatol. 1998; 16 (6): 695–701.Marcos J.C., Maccagno A., Gutfraind E. et al. Efficacy, tolerability and safety of cyclosporine for microemulsion in the treatment of active rheumatoid arthritis. Open study. Medicina (B. Aires). 2000; 60 (4): 435–440.Marcos J.C., Maccagno A., Gutfraind E. et al. Efficacy, tolerability and safety of cyclosporine for microemulsion in the treatment of active rheumatoid arthritis. Open study. Medicina (B. Aires). 2000; 60 (4): 435–440.Di Munno O., Delle Sedie A., Rossini M. et al. Disease modifying antirheumatic drugs and bone mass in rheumatoid arthritis. Clin. Exp. Rheumatol. 2005; 23 (2): 137–144.Di Munno O., Delle Sedie A., Rossini M. et al. Disease modifying antirheumatic drugs and bone mass in rheumatoid arthritis. Clin. Exp. Rheumatol. 2005; 23 (2): 137–144.BabicCNaglic D. Treatment of rheumatoid arthritis. Reumatizam. 2003; 50 (2) 22–27.BabicCNaglic D. Treatment of rheumatoid arthritis. Reumatizam. 2003; 50 (2) 22–27.Johnsen V., Forre O., Haga H.J. et al. Combination therapy in rheumatoid arthritis. Tidsskr. Nor. Laegeforen. 2003; 123 (11): 1511–1513.Johnsen V., Forre O., Haga H.J. et al. Combination therapy in rheumatoid arthritis. Tidsskr. Nor. Laegeforen. 2003; 123 (11): 1511–1513.Алексеева Е.И., Валиева С.И., Апаева Д.В. Эффективность и безопасность комбинированной иммуноcупрессивной терапии циклоспорином А и метотрексатом у больных тяжёлым ювенильным ревматоидным артритом. Вопросы современной педиатрии. Приложение. Ревматические болезни. 2006; 5 (2): 19–27.Алексеева Е.И., Валиева С.И., Апаева Д.В. Эффективность и безопасность комбинированной иммуноcупрессивной терапии циклоспорином А и метотрексатом у больных тяжёлым ювенильным ревматоидным артритом. Вопросы современной педиатрии. Приложение. Ревматические болезни. 2006; 5 (2): 19–27.Ravelli A., Moretti C., Temporini F. et al. Combination therapy with methotrexate and cyclosporine A in juvenile idiopathic arthritis. Clin. Exp. Rheumatol. 2002; 20 (4): 569–572.Ravelli A., Moretti C., Temporini F. et al. Combination therapy with methotrexate and cyclosporine A in juvenile idiopathic arthritis. Clin. Exp. Rheumatol. 2002; 20 (4): 569–572.Hetland M.L., Stengaard-Pedersen K., Junker P. et al. Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: an investigator initiated, multicenter, randomized, double blind, parallel group, placebo controlled study. Arthritis. Rheum. 2006; 54 (5): 1401–1409.Hetland M.L., Stengaard-Pedersen K., Junker P. et al. Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: an investigator initiated, multicenter, randomized, double blind, parallel group, placebo controlled study. Arthritis. Rheum. 2006; 54 (5): 1401–1409.Gremese E., Ferraccioli G.F. Benefit/risk of cyclosporine in rheumatoid arthritis. Clin. Exp. Rheumatol. 2004; 22 (5 Suppl. 35): 101–107.Gremese E., Ferraccioli G.F. Benefit/risk of cyclosporine in rheumatoid arthritis. Clin. Exp. Rheumatol. 2004; 22 (5 Suppl. 35): 101–107.Farooqui A.N., Ahmad S.L., Mansuri F.A. Efficacy of cyclosporine A in refractory rheumatoid arthritis. J. Coll. Physicians Surg. Pak. 2004; 14 (3): 139–141.Farooqui A.N., Ahmad S.L., Mansuri F.A. Efficacy of cyclosporine A in refractory rheumatoid arthritis. J. Coll. Physicians Surg. Pak. 2004; 14 (3): 139–141.Darmawan J., Rasker J.J., Nuralim H. Ten year radiographic out come in patients with rheumatoid factor positive rheumatoid arthritis treated with aggressive immunosuppressive combination therapy. J. Rheumatol. Suppl. 2004; 69: 66–69.Darmawan J., Rasker J.J., Nuralim H. Ten year radiographic out come in patients with rheumatoid factor positive rheumatoid arthritis treated with aggressive immunosuppressive combination therapy. J. Rheumatol. Suppl. 2004; 69: 66–69.Marchesoni A., Battafarano N., Arreghini M. et al. Radiographic progression in early rheumatoid arthritis: a 12 month randomized controlled study comparing the combination of cyclosporin and methotrexate with methotrexate alone. Rheumatol (Oxford). 2003; 42 (12): 1545–1549.Marchesoni A., Battafarano N., Arreghini M. et al. Radiographic progression in early rheumatoid arthritis: a 12 month randomized controlled study comparing the combination of cyclosporin and methotrexate with methotrexate alone. Rheumatol (Oxford). 2003; 42 (12): 1545–1549.Johnsen V., Forre O., Haga H.J. et al. Combination therapy in rheumatoid arthritis. Tidsskr. Nor. Laegeforen. 2003; 123 (11): 1511–1513.Johnsen V., Forre O., Haga H.J. et al. Combination therapy in rheumatoid arthritis. Tidsskr. Nor. Laegeforen. 2003; 123 (11): 1511–1513.Arnett F.C., Edworth S.M., Bloch D.A. et al. The American Rheumatism Association 1987 revised criteria for classification of rheumatoid arthritis. Arthr. Rheum. 1988; 31: 315–324.Arnett F.C., Edworth S.M., Bloch D.A. et al. The American Rheumatism Association 1987 revised criteria for classification of rheumatoid arthritis. Arthr. Rheum. 1988; 31: 315–324.Smolen J.S., Breedveld F.C., Schiff M.H. et al. A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatol. 2003; 42: 144–257.Smolen J.S., Breedveld F.C., Schiff M.H. et al. A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatol. 2003; 42: 144–257.Клинические рекомендации. Ревматология. Под ред. Е.Л. Насонова. М. 2005. С. 120–140.Клинические рекомендации. Ревматология. Под ред. Е.Л. Насонова. М. 2005. С. 120–140.Felson D.T., Anderson J.J., Boers M. et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthr. Rheum. 1993; 36: 729–740.Felson D.T., Anderson J.J., Boers M. et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthr. Rheum. 1993; 36: 729–740.
The authors declare that there are no conflicts of interest present.