<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vsp-1164</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ПОВТОРНЫХ КУРСОВ ЛЕЧЕНИЯ РИТУКСИМАБОМ ТЯЖЕЛОГО РЕФРАКТЕРНОГО ЮВЕНИЛЬНОГО РЕВМАТОИДНОГО АРТРИТА</article-title><trans-title-group xml:lang="en"><trans-title>EFFECTIVENESS AND SAFETY OF REPEATED COURSES OF TREATMENT WITH RITUXIMAB IN PATIENTS WITH SEVERE REFRACTORY IDIOPATHIC ARTHRITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Е.И.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexeeva</surname><given-names>E.I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Валиева</surname><given-names>С.И.</given-names></name><name name-style="western" xml:lang="en"><surname>Valieva</surname><given-names>S.I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бзарова</surname><given-names>Т.М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bzarova</surname><given-names>T.M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семикина</surname><given-names>Е.Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Semikina</surname><given-names>E.L.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исаева</surname><given-names>К.Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Isaeva</surname><given-names>K.B.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лисицин</surname><given-names>А.О.</given-names></name><name name-style="western" xml:lang="en"><surname>Lisitsin</surname><given-names>A.O.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>Р.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>R.V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гудкова</surname><given-names>Е.Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Gudkova</surname><given-names>E.Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>23</day><month>09</month><year>2015</year></pub-date><volume>8</volume><issue>5</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>19</fpage><lpage>30</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алексеева Е., Валиева С., Бзарова Т., Семикина Е., Исаева К., Лисицин А., Денисова Р., Гудкова Е., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Алексеева Е., Валиева С., Бзарова Т., Семикина Е., Исаева К., Лисицин А., Денисова Р., Гудкова Е.</copyright-holder><copyright-holder xml:lang="en">Alexeeva E., Valieva S., Bzarova T., Semikina E., Isaeva K., Lisitsin A., Denisova R., Gudkova E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/1164">https://vsp.spr-journal.ru/jour/article/view/1164</self-uri><abstract/><trans-abstract xml:lang="en"/></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gabriel SE. The epidemiology of rheumatoid arthritis. Rheum. Dis. Clin. North Аm. 2001; 27: 269–281.</mixed-citation><mixed-citation xml:lang="en">Gabriel SE. The epidemiology of rheumatoid arthritis. Rheum. Dis. Clin. North Аm. 2001; 27: 269–281.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">El-Gabalawy HD, Lipsky PE. Why do we not have a cure for rheumatoid arthritis? Arthritis Rheum. 2002; 4 (Suppl. 3): 297–301.</mixed-citation><mixed-citation xml:lang="en">El-Gabalawy HD, Lipsky PE. Why do we not have a cure for rheumatoid arthritis? Arthritis Rheum. 2002; 4 (Suppl. 3): 297–301.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. Фармакотерапия ревматоидного артрита – взгляд в 21 век. Клиническая медицина. 2005; 6: 8–12.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л. Фармакотерапия ревматоидного артрита – взгляд в 21 век. Клиническая медицина. 2005; 6: 8–12.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. Лечение ревматоидного артрита: современное состояние проблемы. РМЖ. 2006; 14 (8): 573–577.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л. Лечение ревматоидного артрита: современное состояние проблемы. РМЖ. 2006; 14 (8): 573–577.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Textbook of pediatric rheumatology. 5th Ed. Cassidy J., Petty R. Elsevier Saunders. 2005.</mixed-citation><mixed-citation xml:lang="en">Textbook of pediatric rheumatology. 5th Ed. Cassidy J., Petty R. Elsevier Saunders. 2005.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.И., Литвицкий П.Ф. Ювенильный ревматоидный артрит. Этиология. Патогенез. Клиника. Алгоритмы диагностики и лечения. Руководство для врачей, преподавателей, научных сотрудников. Под общей ред. А.А. Баранова. М. 2007. С. 325-339.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е.И., Литвицкий П.Ф. Ювенильный ревматоидный артрит. Этиология. Патогенез. Клиника. Алгоритмы диагностики и лечения. Руководство для врачей, преподавателей, научных сотрудников. Под общей ред. А.А. Баранова. М. 2007. С. 325-339.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Woo P., Southwood T.R., Prieur A.M. Randomized, placebo-controlled, crossover trial of low-dose oral methotrexate in children with extended oligoarticular or systemic arthritis. Arthritis Rheum. 2000; 43 (8): 1849–1857.</mixed-citation><mixed-citation xml:lang="en">Woo P., Southwood T.R., Prieur A.M. Randomized, placebo-controlled, crossover trial of low-dose oral methotrexate in children with extended oligoarticular or systemic arthritis. Arthritis Rheum. 2000; 43 (8): 1849–1857.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. Ритуксимаб в лечении ревматических болезней. Научно–практическая ревматология. 2008; 1 (приложение): 3–10.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л. Ритуксимаб в лечении ревматических болезней. Научно–практическая ревматология. 2008; 1 (приложение): 3–10.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kotzin B.L. The role of B–cells in the pathogenesis of rheumatoid arthritis. J. Rheumatol. 2005; 73: 14-18.</mixed-citation><mixed-citation xml:lang="en">Kotzin B.L. The role of B–cells in the pathogenesis of rheumatoid arthritis. J. Rheumatol. 2005; 73: 14-18.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Z., Bridges S.L. Jr. Pathogenesis of rheumatoid arthritis: role of B lymphocytes. Rheum. Dis. Clin. North Am. 2001; 27: 335–353.</mixed-citation><mixed-citation xml:lang="en">Zhang Z., Bridges S.L. Jr. Pathogenesis of rheumatoid arthritis: role of B lymphocytes. Rheum. Dis. Clin. North Am. 2001; 27: 335–353.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Furst D.E., Breedveld F.C., Kalden J.R. et al. Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007. Ann. Rheum. Dis. 2007; 66: 2-22.</mixed-citation><mixed-citation xml:lang="en">Furst D.E., Breedveld F.C., Kalden J.R. et al. Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007. Ann. Rheum. Dis. 2007; 66: 2-22.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов ЕЛ. Перспективы применения моноклональных антител к В–лимфоцитам (ритуксимаб) при ревматоидном артрите. Клиническая фармакология и терапия. 2006; 1 (5): 55–58.</mixed-citation><mixed-citation xml:lang="en">Насонов ЕЛ. Перспективы применения моноклональных антител к В–лимфоцитам (ритуксимаб) при ревматоидном артрите. Клиническая фармакология и терапия. 2006; 1 (5): 55–58.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. Новые направления терапии ревматоидного артрита: перспективы применения моноклональных антител к В–лимфоцитам (ритуксимаб). РМЖ. 2006; 25: 1778–1782.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л. Новые направления терапии ревматоидного артрита: перспективы применения моноклональных антител к В–лимфоцитам (ритуксимаб). РМЖ. 2006; 25: 1778–1782.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Smolen J.S., Betteridge N., Breedveld F.C. et al. Consensus statement on the use of rituximab in patients with rheumatoid arthritis. Ann. Rheum. Dis. 2007; 66: 143–150.</mixed-citation><mixed-citation xml:lang="en">Smolen J.S., Betteridge N., Breedveld F.C. et al. Consensus statement on the use of rituximab in patients with rheumatoid arthritis. Ann. Rheum. Dis. 2007; 66: 143–150.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Finckh A., Ciurea A., Brulhart L. et al. B cell depletion may be more effective than switching to an alternative anti-tumor necrosis factor agent in rheumatoid arthritis patients with inadequate response to anti-tumor necrosis factor agents. Arthritis Rheum. 2007; 56: 1417–1423.</mixed-citation><mixed-citation xml:lang="en">Finckh A., Ciurea A., Brulhart L. et al. B cell depletion may be more effective than switching to an alternative anti-tumor necrosis factor agent in rheumatoid arthritis patients with inadequate response to anti-tumor necrosis factor agents. Arthritis Rheum. 2007; 56: 1417–1423.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Соловьев С.К., Котовская М.А., Насонов Е.Л. Ритуксимаб в лечении системной красной волчанки. РМЖ. 2005; 13: 1731–1735.</mixed-citation><mixed-citation xml:lang="en">Соловьев С.К., Котовская М.А., Насонов Е.Л. Ритуксимаб в лечении системной красной волчанки. РМЖ. 2005; 13: 1731–1735.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. Перспективы применения ритуксимаба при аутоиммунных заболеваниях человека. РМЖ. 2007; 15 (26): 1958–1963.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л. Перспективы применения ритуксимаба при аутоиммунных заболеваниях человека. РМЖ. 2007; 15 (26): 1958–1963.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson P., Glennie M. The mechanism of action of rituximab in the elimination of tumor cells. Semin. Oncol. 2003; 30 (Suppl. 2): 3–8.</mixed-citation><mixed-citation xml:lang="en">Johnson P., Glennie M. The mechanism of action of rituximab in the elimination of tumor cells. Semin. Oncol. 2003; 30 (Suppl. 2): 3–8.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hansen A., Lipsky P. E., Dorner T. B cell lymphoproliferation in chronic inflammatory rheumatic diseases. Nature Clin. Pracr. Rheumatol. 2007; 3: 561.</mixed-citation><mixed-citation xml:lang="en">Hansen A., Lipsky P. E., Dorner T. B cell lymphoproliferation in chronic inflammatory rheumatic diseases. Nature Clin. Pracr. Rheumatol. 2007; 3: 561.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Youinou P., Jamin C., Saraux A. B-cell: a logical target for treatment of rheumatoid arthritis. Clin. Exp. Rheumatol. 2007; 25: 318–328.</mixed-citation><mixed-citation xml:lang="en">Youinou P., Jamin C., Saraux A. B-cell: a logical target for treatment of rheumatoid arthritis. Clin. Exp. Rheumatol. 2007; 25: 318–328.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Browning J. L. B–cell move to center stage: novel opportunities for autoimmune disease treatment. Nature Rev. 2006; 5: 564–576.</mixed-citation><mixed-citation xml:lang="en">Browning J. L. B–cell move to center stage: novel opportunities for autoimmune disease treatment. Nature Rev. 2006; 5: 564–576.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Bizzaro N., Tozzoli R., Shoenfeld Y. Are we at stage to predict autoimmune rheumatic diseases? Arthritis Rheum. 2007; 56: 1736–1744.</mixed-citation><mixed-citation xml:lang="en">Bizzaro N., Tozzoli R., Shoenfeld Y. Are we at stage to predict autoimmune rheumatic diseases? Arthritis Rheum. 2007; 56: 1736–1744.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards J.C.W., Cambridge G., Leandro M.J. B cell depletion therapy in rheumatic disease. Best Pract. Res. Clin. Rheumatol. 2006; 20: 915–928.</mixed-citation><mixed-citation xml:lang="en">Edwards J.C.W., Cambridge G., Leandro M.J. B cell depletion therapy in rheumatic disease. Best Pract. Res. Clin. Rheumatol. 2006; 20: 915–928.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Shan D., Ledbetter J.A., Press O.W. Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies. Blood. 1998; 91 (5): 1644–1652.</mixed-citation><mixed-citation xml:lang="en">Shan D., Ledbetter J.A., Press O.W. Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies. Blood. 1998; 91 (5): 1644–1652.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">McLaughlin P., Grillo-Lopez A.J., Link B.K. et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four dose treatment program. J. Clin. Oncol. 1998; 16: 2825–2833.</mixed-citation><mixed-citation xml:lang="en">McLaughlin P., Grillo-Lopez A.J., Link B.K. et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four dose treatment program. J. Clin. Oncol. 1998; 16: 2825–2833.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Panayi G.S. B cell-directed therapy in rheumatoid arthritis clinical experience. J. Rheumatol. Suppl. 2005; 73: 19–24.</mixed-citation><mixed-citation xml:lang="en">Panayi G.S. B cell-directed therapy in rheumatoid arthritis clinical experience. J. Rheumatol. Suppl. 2005; 73: 19–24.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Plosker G.L., Figgitt D.P. Rituximab: a review of its use in non-Hodgkin’s lymphoma and chronic lymphocytic leukaemia. Drugs. 2003; 63: 803–843.</mixed-citation><mixed-citation xml:lang="en">Plosker G.L., Figgitt D.P. Rituximab: a review of its use in non-Hodgkin’s lymphoma and chronic lymphocytic leukaemia. Drugs. 2003; 63: 803–843.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Hainsworth J.D. Safety of rituximab in the treatment of B–cell malignancies: implications for rheumatoid arthritis. Arthritis Res. Ther. 2003; 5 (Suppl. 4): 12–16.</mixed-citation><mixed-citation xml:lang="en">Hainsworth J.D. Safety of rituximab in the treatment of B–cell malignancies: implications for rheumatoid arthritis. Arthritis Res. Ther. 2003; 5 (Suppl. 4): 12–16.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Anolik J.H., Campbell D., Felgar R.E. et al. The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus. Arthritis Rheum. 2003; 48: 455–459.</mixed-citation><mixed-citation xml:lang="en">Anolik J.H., Campbell D., Felgar R.E. et al. The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus. Arthritis Rheum. 2003; 48: 455–459.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Bhat N.M., Lee L.M., van Vollenhoven R.F. et al. VH4-34 encoded antibody in systemic lupus erythematosus: effect of isotype. J. Rheumatol. 2002; 29: 2114–2121.</mixed-citation><mixed-citation xml:lang="en">Bhat N.M., Lee L.M., van Vollenhoven R.F. et al. VH4-34 encoded antibody in systemic lupus erythematosus: effect of isotype. J. Rheumatol. 2002; 29: 2114–2121.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Pugh-Bernard A.E., Silverman G.J., Cappione A.J. et al. Regulation of inherently autoreactive VH4–34 B cells in the maintenance of human B–cell tolerance. J. Clin. Invest. 2001; 108: 1061–1070.</mixed-citation><mixed-citation xml:lang="en">Pugh-Bernard A.E., Silverman G.J., Cappione A.J. et al. Regulation of inherently autoreactive VH4–34 B cells in the maintenance of human B–cell tolerance. J. Clin. Invest. 2001; 108: 1061–1070.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Leandro M.J., Ehrenstein M.R., Edwards J.C. et al. Treatment of refractory lupus nephritis with B lymphocyte depletion. Arthritis Rheum. 2003; 48: 378.</mixed-citation><mixed-citation xml:lang="en">Leandro M.J., Ehrenstein M.R., Edwards J.C. et al. Treatment of refractory lupus nephritis with B lymphocyte depletion. Arthritis Rheum. 2003; 48: 378.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Patel K., Berman J., Ferber A. et al. Refractory autoimmune thrombocytopenic purpura treatment with rituximab. Am. J. Hematol. 2001; 67: 59–60.</mixed-citation><mixed-citation xml:lang="en">Patel K., Berman J., Ferber A. et al. Refractory autoimmune thrombocytopenic purpura treatment with rituximab. Am. J. Hematol. 2001; 67: 59–60.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Stasi R., Pagano A., Stipa E. et al. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood. 2001; 98: 952–957.</mixed-citation><mixed-citation xml:lang="en">Stasi R., Pagano A., Stipa E. et al. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood. 2001; 98: 952–957.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Berentsen S., Tjonnfjord G.E., Brudevold R. et al. Favorable response to therapy with the anti-CD20 monoclonal antibody rituximab in primary chronic cold agglutinin disease. Br. J. Haematol. 2001; 115: 79–83.</mixed-citation><mixed-citation xml:lang="en">Berentsen S., Tjonnfjord G.E., Brudevold R. et al. Favorable response to therapy with the anti-CD20 monoclonal antibody rituximab in primary chronic cold agglutinin disease. Br. J. Haematol. 2001; 115: 79–83.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Quartier P., Brethon B., Philippet P. et al. Treatment of childhood autoimmune haemolytic anaemia with rituximab. Lancet. 2001; 358: 1511–1513.</mixed-citation><mixed-citation xml:lang="en">Quartier P., Brethon B., Philippet P. et al. Treatment of childhood autoimmune haemolytic anaemia with rituximab. Lancet. 2001; 358: 1511–1513.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Zecca M., Nobili B., Ramenghi U. et al. Rituximab for the treatment of refractory autoimmune hemolytic anemia in children. Blood. 2003; 101: 3857–3861.</mixed-citation><mixed-citation xml:lang="en">Zecca M., Nobili B., Ramenghi U. et al. Rituximab for the treatment of refractory autoimmune hemolytic anemia in children. Blood. 2003; 101: 3857–3861.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ruggenenti P., Chiurchiu C., Brusegan V. et al. Rituximab in idiopathic membranous nephropathy: a one-year prospective study. J. Am. Soc. Nephrol. 2003; 14: 1851–1857.</mixed-citation><mixed-citation xml:lang="en">Ruggenenti P., Chiurchiu C., Brusegan V. et al. Rituximab in idiopathic membranous nephropathy: a one-year prospective study. J. Am. Soc. Nephrol. 2003; 14: 1851–1857.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Levine T.D. Rituximab in the treatment of dermatomyositis: an open-label pilot study. Arthritis Rheum. 2005; 52 (2): 601–607.</mixed-citation><mixed-citation xml:lang="en">Levine T.D. Rituximab in the treatment of dermatomyositis: an open-label pilot study. Arthritis Rheum. 2005; 52 (2): 601–607.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Xiao X., Heeringa P., Hu P. et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J. Clin. Invest. 2002; 110: 955–963.</mixed-citation><mixed-citation xml:lang="en">Xiao X., Heeringa P., Hu P. et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J. Clin. Invest. 2002; 110: 955–963.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Eriksson P. Short term outcome and safety in 5 patients with ANCA-positive vasculitis treated with rituximab. 11th International Vasculitis and ANCA Workshop 2003. Kidney Blood Pressure Res. 2003; 26: 294.</mixed-citation><mixed-citation xml:lang="en">Eriksson P. Short term outcome and safety in 5 patients with ANCA-positive vasculitis treated with rituximab. 11th International Vasculitis and ANCA Workshop 2003. Kidney Blood Pressure Res. 2003; 26: 294.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Jayne D., Burns S., Smith K. A prospective, open label trial of B-cell depletion with rituximab in refractory systemic vasculitis. 11th International Vasculitis and ANCA Workshop 2003. Kidney Blood Pressure Res. 2003; 26: 294.</mixed-citation><mixed-citation xml:lang="en">Jayne D., Burns S., Smith K. A prospective, open label trial of B-cell depletion with rituximab in refractory systemic vasculitis. 11th International Vasculitis and ANCA Workshop 2003. Kidney Blood Pressure Res. 2003; 26: 294.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards J.C., Cambridge G. Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology. 2001; 40: 205–211.</mixed-citation><mixed-citation xml:lang="en">Edwards J.C., Cambridge G. Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology. 2001; 40: 205–211.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Looney R.J., Anolik J., Sanz I. B cells as therapeutic targets for rheumatic diseases. Current Opinion Rheumatol. 2004; 16: 180–185.</mixed-citation><mixed-citation xml:lang="en">Looney R.J., Anolik J., Sanz I. B cells as therapeutic targets for rheumatic diseases. Current Opinion Rheumatol. 2004; 16: 180–185.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Stahl H.D., Szczepanski L., Szechinski J. et al. Rituximab in RA: efficacy and safety from a randomized controlled trial. Ann. Rheum. Dis. 2003; 62: 65.</mixed-citation><mixed-citation xml:lang="en">Stahl H.D., Szczepanski L., Szechinski J. et al. Rituximab in RA: efficacy and safety from a randomized controlled trial. Ann. Rheum. Dis. 2003; 62: 65.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Emery P., Szczepanski L., Szechinski J. et al. Sustained efficacy at 48 weeks after a single treatment course of rituximab in patients with RA. Arthritis Rheum. 2003; 48: 439.</mixed-citation><mixed-citation xml:lang="en">Emery P., Szczepanski L., Szechinski J. et al. Sustained efficacy at 48 weeks after a single treatment course of rituximab in patients with RA. Arthritis Rheum. 2003; 48: 439.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.И, Бзарова Т.М., Семикина Е.Л, Акулова С.С. Опыт применения ритуксимаба у больной с системным ювенильным ревматоидным артритом. Вопросы современной педиатрии. 2006; 5 (6): 96–100.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е.И, Бзарова Т.М., Семикина Е.Л, Акулова С.С. Опыт применения ритуксимаба у больной с системным ювенильным ревматоидным артритом. Вопросы современной педиатрии. 2006; 5 (6): 96–100.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.И., Бзарова Т.М., Валиева С.И. и др. Ритуксимаб: новые возможности лечения тяжелого рефрактерного ювенильного артрита. Вопросы современной педиатрии. 2008; 7 (2): 22–30.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е.И., Бзарова Т.М., Валиева С.И. и др. Ритуксимаб: новые возможности лечения тяжелого рефрактерного ювенильного артрита. Вопросы современной педиатрии. 2008; 7 (2): 22–30.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace C.A., Ruperto N., Giannini E; Childhood Arthritis and Rheumatology Research Alliance; Pediatric Rheumatology International Trials Organization; Pediatric Rheumatology Collaborative Study Group. Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J. Rheumatol. 2004; 31 (11): 2290–2294.</mixed-citation><mixed-citation xml:lang="en">Wallace C.A., Ruperto N., Giannini E; Childhood Arthritis and Rheumatology Research Alliance; Pediatric Rheumatology International Trials Organization; Pediatric Rheumatology Collaborative Study Group. Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J. Rheumatol. 2004; 31 (11): 2290–2294.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
