<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vsp-1210</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ  ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>A DOCTOR’S AID</subject></subj-group></article-categories><title-group><article-title>РАННЯЯ ДИФФЕРЕНЦИАЛЬНАЯ ДИАГНОСТИКА И ДЛИТЕЛЬНАЯ ИММУНОМОДУЛИРУЮЩАЯ ТЕРАПИЯ ХРОНИЧЕСКИХ ВОСПАЛИТЕЛЬНЫХ ДЕМИЕЛИНИЗИРУЮЩИХ ЗАБОЛЕВАНИЙ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ У ДЕТЕЙ И ПОДРОСТКОВ</article-title><trans-title-group xml:lang="en"><trans-title>EARLY DIFFERENTIAL DIAGNOSTICS AND PROLONGED IMMUNOMODULATORY THERAPY OF CHRONIC INFLAMMATORY DEMYELINATING DISEASES OF CENTRAL NERVOUS SYSTEM IN CHILDREN AND ADOLESCENTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Быкова</surname><given-names>О.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bykova</surname><given-names>O.V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Платонова</surname><given-names>А.Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Platonova</surname><given-names>A.N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гольцова</surname><given-names>Н.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gol'tsova</surname><given-names>N.V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>Г.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>G.V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузенкова</surname><given-names>Л.М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzenkova</surname><given-names>L.M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бойко</surname><given-names>А.Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Boiko</surname><given-names>A.N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский государственный медицинский университет, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian State Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>24</day><month>09</month><year>2015</year></pub-date><volume>8</volume><issue>6</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>139</fpage><lpage>145</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Быкова О., Платонова А., Гольцова Н., Кузнецова Г., Кузенкова Л., Бойко А., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Быкова О., Платонова А., Гольцова Н., Кузнецова Г., Кузенкова Л., Бойко А.</copyright-holder><copyright-holder xml:lang="en">Bykova O., Platonova A., Gol'tsova N., Kuznetsova G., Kuzenkova L., Boiko A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/1210">https://vsp.spr-journal.ru/jour/article/view/1210</self-uri><abstract/><trans-abstract xml:lang="en"/></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Barkhof F., Polman C., Radue E.W. et al. Betaferon in Newly Emerging Multiple Sclerosis for Initial Treatment (BENEFIT): magnetic resonance imaging outcomes. 21-th Congress of the European Committee for Treatment and Research in Multiple Sclerosis. Greece. 2005. P. 583.</mixed-citation><mixed-citation xml:lang="en">Barkhof F., Polman C., Radue E.W. et al. Betaferon in Newly Emerging Multiple Sclerosis for Initial Treatment (BENEFIT): magnetic resonance imaging outcomes. 21-th Congress of the European Committee for Treatment and Research in Multiple Sclerosis. Greece. 2005. P. 583.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Dale R.C., de Sousa C., Chong W.K. et al. Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain. 2000; 123 (12): 2407–2422.</mixed-citation><mixed-citation xml:lang="en">Dale R.C., de Sousa C., Chong W.K. et al. Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain. 2000; 123 (12): 2407–2422.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hahn C.D., Shroff M.M., Blaser S.I., Banwell B.L. MRI criteria for multiple sclerosis: evaluation in a pediatric cohort. Neurology. 2004; 62: 806–808.</mixed-citation><mixed-citation xml:lang="en">Hahn C.D., Shroff M.M., Blaser S.I., Banwell B.L. MRI criteria for multiple sclerosis: evaluation in a pediatric cohort. Neurology. 2004; 62: 806–808.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hynson J.L., Kornberg A.J., Coleman L.T. et al. Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. Neurology. 2001; 56: 1308–1312.</mixed-citation><mixed-citation xml:lang="en">Hynson J.L., Kornberg A.J., Coleman L.T. et al. Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children. Neurology. 2001; 56: 1308–1312.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Idrissova Z., Boldyreva M.N., Dekonenko E.P. et al. Acute disseminated encephalomyelitis in children: clinical features and HLA–DR linkage. Eur. J. Neurol. 2003; 10: 537–546.</mixed-citation><mixed-citation xml:lang="en">Idrissova Z., Boldyreva M.N., Dekonenko E.P. et al. Acute disseminated encephalomyelitis in children: clinical features and HLA–DR linkage. Eur. J. Neurol. 2003; 10: 537–546.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Jacobs L.D., Beck R.W., Simon J.H. et al. CHAMPS Study Group. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. N. Engl. J. Med. 2000; 343: 898–904.</mixed-citation><mixed-citation xml:lang="en">Jacobs L.D., Beck R.W., Simon J.H. et al. CHAMPS Study Group. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. N. Engl. J. Med. 2000; 343: 898–904.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Krupp L., Pohl D., Rostasy K. et al. CSF characteristics in early-onset multiple sclerosis. Neurology. 2004; 63: 1966–1967.</mixed-citation><mixed-citation xml:lang="en">Krupp L., Pohl D., Rostasy K. et al. CSF characteristics in early-onset multiple sclerosis. Neurology. 2004; 63: 1966–1967.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Krupp Lauren B., Banwell B., Tenembaum S., for the International Pediatric MS Study Group. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology. 2007; 68: 7–12.</mixed-citation><mixed-citation xml:lang="en">Krupp Lauren B., Banwell B., Tenembaum S., for the International Pediatric MS Study Group. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology. 2007; 68: 7–12.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Marchioni E., Ravaglia S., Piccolo G. et al. Postinfectious inflammatory disorders: subgroups based on prospective follow up. Neurology. 2005; 65: 1057–1065.</mixed-citation><mixed-citation xml:lang="en">Marchioni E., Ravaglia S., Piccolo G. et al. Postinfectious inflammatory disorders: subgroups based on prospective follow up. Neurology. 2005; 65: 1057–1065.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">McDonald W.I., Compston A., Edan G. et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 2001; 50: 121–127.</mixed-citation><mixed-citation xml:lang="en">McDonald W.I., Compston A., Edan G. et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 2001; 50: 121–127.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mikaeloff Y., Adamsbaum C., Husson B. et al. MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood. Brain. 2004; 127: 1942–1947.</mixed-citation><mixed-citation xml:lang="en">Mikaeloff Y., Adamsbaum C., Husson B. et al. MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood. Brain. 2004; 127: 1942–1947.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mikaeloff Y., Suissa S., Vallee L. et al. First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disability. J. Pediatr. 2004; 144: 246–252.</mixed-citation><mixed-citation xml:lang="en">Mikaeloff Y., Suissa S., Vallee L. et al. First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disability. J. Pediatr. 2004; 144: 246–252.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Panitch H., Goodin D.S., Francis G. et al. Randomized, comparative study of interferon beta-1a treatment regimens in MS: The EVIDENCE Trial. Neurology. 2002; 59: 1496–1506.</mixed-citation><mixed-citation xml:lang="en">Panitch H., Goodin D.S., Francis G. et al. Randomized, comparative study of interferon beta-1a treatment regimens in MS: The EVIDENCE Trial. Neurology. 2002; 59: 1496–1506.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Pittock S.J., Wingerchuk D.M., Krecke K. et al. Brain abnormalities in patients with neuromyelitis optica (NMO). Neurology. 2005; 64: 39.</mixed-citation><mixed-citation xml:lang="en">Pittock S.J., Wingerchuk D.M., Krecke K. et al. Brain abnormalities in patients with neuromyelitis optica (NMO). Neurology. 2005; 64: 39.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pohl D., Waubant E., Banwell B. et al. Treatment of pediatric multiple sclerosis and variants. Neurology. 2007; 68 (2): 54–65.</mixed-citation><mixed-citation xml:lang="en">Pohl D., Waubant E., Banwell B. et al. Treatment of pediatric multiple sclerosis and variants. Neurology. 2007; 68 (2): 54–65.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Poser C.M., Paty D.W., Scheinberg L. et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 1983; 13: 227–231.</mixed-citation><mixed-citation xml:lang="en">Poser C.M., Paty D.W., Scheinberg L. et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 1983; 13: 227–231.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ruggieri M., Iannetti P., Polizzi A. et al. Multiple sclerosis in children under 10 years of age. Neurol. Sci. 2004; 25 (4): 326–335.</mixed-citation><mixed-citation xml:lang="en">Ruggieri M., Iannetti P., Polizzi A. et al. Multiple sclerosis in children under 10 years of age. Neurol. Sci. 2004; 25 (4): 326–335.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Schumacker G.A., Beebe G., Kibler R.F. et al. Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann. N.Y. Acad. Sci. 1965; 122: 552–568.</mixed-citation><mixed-citation xml:lang="en">Schumacker G.A., Beebe G., Kibler R.F. et al. Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann. N.Y. Acad. Sci. 1965; 122: 552–568.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tenembaum S., Chamoles N., Fejerman N. Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients. Neurology. 2002; 59: 1224–1231.</mixed-citation><mixed-citation xml:lang="en">Tenembaum S., Chamoles N., Fejerman N. Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients. Neurology. 2002; 59: 1224–1231.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Wingerchuk D.M., Pittock S.J., Lennon V.A. et al. Neuromyelitis optica diagnostic criteria revisited: Validation and incorporation of the NMO–IgG serum autoantibody. Neurology. 2005; 64: 38.</mixed-citation><mixed-citation xml:lang="en">Wingerchuk D.M., Pittock S.J., Lennon V.A. et al. Neuromyelitis optica diagnostic criteria revisited: Validation and incorporation of the NMO–IgG serum autoantibody. Neurology. 2005; 64: 38.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Wingerchuk D.M., Weinshenker B.G. Neuromyelitis optica - Clinical predictors of a relapsing course and survival. Neurology. 2003; 60: 848–853.</mixed-citation><mixed-citation xml:lang="en">Wingerchuk D.M., Weinshenker B.G. Neuromyelitis optica - Clinical predictors of a relapsing course and survival. Neurology. 2003; 60: 848–853.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Wingerchuk D.M. Acute disseminated encephalomyelitis: distinction from multiple sclerosis and treatment issues. Adv. Neurol. 2006; 98: 303–318.</mixed-citation><mixed-citation xml:lang="en">Wingerchuk D.M. Acute disseminated encephalomyelitis: distinction from multiple sclerosis and treatment issues. Adv. Neurol. 2006; 98: 303–318.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
