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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vsp-1285</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>ФАКТОРЫ РИСКА РАННЕГО РАЗВИТИЯ КАРДИОВАСКУЛЯРНОЙПАТОЛОГИИ У ДЕТЕЙ, СТРАДАЮЩИХ ЮВЕНИЛЬНЫМ РЕВМАТОИДНЫМ АРТРИТОМ</article-title><trans-title-group xml:lang="en"><trans-title>RISK FACTORS OF EARLY CARDIOVASCULAR PATHOLOGY OF CHILDREN SUFFERING FROM JUVENILE RHEUMATIC ARTHRITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гудкова</surname><given-names>Е.Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Gudkova</surname><given-names>E.Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Е.И.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexeeva</surname><given-names>E.I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2007</year></pub-date><pub-date pub-type="epub"><day>21</day><month>10</month><year>2015</year></pub-date><volume>6</volume><issue>5</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>74</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гудкова Е., Алексеева Е., 2007</copyright-statement><copyright-year>2007</copyright-year><copyright-holder xml:lang="ru">Гудкова Е., Алексеева Е.</copyright-holder><copyright-holder xml:lang="en">Gudkova E., Alexeeva E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/1285">https://vsp.spr-journal.ru/jour/article/view/1285</self-uri><abstract/><trans-abstract xml:lang="en"/></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. Ревматология. Под ред. Е.Л. Насонова М.: ГЭОТАР-Медиа. 2005.</mixed-citation><mixed-citation xml:lang="en">Клинические рекомендации. Ревматология. Под ред. Е.Л. Насонова М.: ГЭОТАР-Медиа. 2005.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.И., Жолобова Е.С., Чистякова Е.Г, Бзарова Т.М. Ювенильный ревматоидный артрит. Учебно-методическое пособие. М. 2004.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е.И., Жолобова Е.С., Чистякова Е.Г, Бзарова Т.М. Ювенильный ревматоидный артрит. Учебно-методическое пособие. М. 2004.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Goodson N. Coronary artery disease and rheumatoid arthritis. Curr. Opin. Rheumatol. 2002; 14: 115–120.</mixed-citation><mixed-citation xml:lang="en">Goodson N. Coronary artery disease and rheumatoid arthritis. Curr. Opin. Rheumatol. 2002; 14: 115–120.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Goodson N., Marks J., Lunt M. et al. Cardiovascular admissions and mortality in an inception cohort of patients with rheumatoid arthritis with onset in the 1980s and 1990s. Arthritis Rheum. 2005.</mixed-citation><mixed-citation xml:lang="en">Goodson N., Marks J., Lunt M. et al. Cardiovascular admissions and mortality in an inception cohort of patients with rheumatoid arthritis with onset in the 1980s and 1990s. Arthritis Rheum. 2005.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Pincus T., Sokka T., Wolfe F. Premature mortality in patients with rheumatoid arthritis: evolving concepts. Arthritis Rheum. 2001; 44: 1234-1236.</mixed-citation><mixed-citation xml:lang="en">Pincus T., Sokka T., Wolfe F. Premature mortality in patients with rheumatoid arthritis: evolving concepts. Arthritis Rheum. 2001; 44: 1234-1236.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Maradit–Kremers H., Crowson C.S., Nicola P.J. et al. Increased unrecognized coronary heart disease and sudden death in rheumatoid arthritis. A population based controlled study. Arthritis Rheum. 2005; 52: 722–732.</mixed-citation><mixed-citation xml:lang="en">Maradit–Kremers H., Crowson C.S., Nicola P.J. et al. Increased unrecognized coronary heart disease and sudden death in rheumatoid arthritis. A population based controlled study. Arthritis Rheum. 2005; 52: 722–732.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Goodson N.J., Wiles N.J., Lunt M. et al. Mortality in Early inflammatory polyarthritis. Cardiovascular mortality is increased in seropositive patients. Arthritis Rheum. 2002; 46: 2010–2019.</mixed-citation><mixed-citation xml:lang="en">Goodson N.J., Wiles N.J., Lunt M. et al. Mortality in Early inflammatory polyarthritis. Cardiovascular mortality is increased in seropositive patients. Arthritis Rheum. 2002; 46: 2010–2019.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kitas G.D., Blank M.J., Bacon P.A. Cardiac involvement in rheumatoid disease. Clin. Med. JRCPL. 2001; 1: 18–21.</mixed-citation><mixed-citation xml:lang="en">Kitas G.D., Blank M.J., Bacon P.A. Cardiac involvement in rheumatoid disease. Clin. Med. JRCPL. 2001; 1: 18–21.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Van Dorum S., McColl G., Wicks I.P. Accelerated atherosclerosis. An exraarticular feature of rheumatoid arthritis. Arthritis Rheum. 2002; 46: 862–875.</mixed-citation><mixed-citation xml:lang="en">Van Dorum S., McColl G., Wicks I.P. Accelerated atherosclerosis. An exraarticular feature of rheumatoid arthritis. Arthritis Rheum. 2002; 46: 862–875.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kitas G.D., Erb N. Tackling ischemic heart disease in rheumatoid arthritis. Rheumatology. 2003; 42: 607–613.</mixed-citation><mixed-citation xml:lang="en">Kitas G.D., Erb N. Tackling ischemic heart disease in rheumatoid arthritis. Rheumatology. 2003; 42: 607–613.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sattar N., McCrey D.W., Capell H., McInnes I.B. Explaining how “high-grade” systemic inflammation accelerated vascular risk in rheumatoid arthritis. Circulation. 2003; 108: 2957–2963.</mixed-citation><mixed-citation xml:lang="en">Sattar N., McCrey D.W., Capell H., McInnes I.B. Explaining how “high-grade” systemic inflammation accelerated vascular risk in rheumatoid arthritis. Circulation. 2003; 108: 2957–2963.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Manzi S., Wasco M.C. Inflammation mediated rheumatic disease and atherosclerosis. Ann. Rheum. Dis. 2000; 59: 321–325.</mixed-citation><mixed-citation xml:lang="en">Manzi S., Wasco M.C. Inflammation mediated rheumatic disease and atherosclerosis. Ann. Rheum. Dis. 2000; 59: 321–325.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. Проблема атеротромбоза в ревматологии. Вестник РАМН. 2003; 7: 6-10.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л. Проблема атеротромбоза в ревматологии. Вестник РАМН. 2003; 7: 6-10.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chung C.P., Avalos I., Raggi P. Atherosclerosis and inflammation: insights from rheumatoid arthritis. Clin. Rheumatol. 2007; 26 (8): 1228–1233.</mixed-citation><mixed-citation xml:lang="en">Chung C.P., Avalos I., Raggi P. Atherosclerosis and inflammation: insights from rheumatoid arthritis. Clin. Rheumatol. 2007; 26 (8): 1228–1233.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. Иммунологические маркеры атеросклероза. Терапевтический архив. 2002; 5: 80–85.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л. Иммунологические маркеры атеросклероза. Терапевтический архив. 2002; 5: 80–85.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Szmitko P.E., Wang C.H., Weisel R.D. et al. New markers of inflammation and endothelial cell activation. Part I. Circulation. 2003; 108: 1917–1923.</mixed-citation><mixed-citation xml:lang="en">Szmitko P.E., Wang C.H., Weisel R.D. et al. New markers of inflammation and endothelial cell activation. Part I. Circulation. 2003; 108: 1917–1923.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Szmitko P.E., Wang C.H., Weisel R.D. et al. New markers of inflammation and endothelial cell activation, part II. Circulation. 2003; 108: 2041–2048.</mixed-citation><mixed-citation xml:lang="en">Szmitko P.E., Wang C.H., Weisel R.D. et al. New markers of inflammation and endothelial cell activation, part II. Circulation. 2003; 108: 2041–2048.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л. Иммунологические маркеры атеросклероза. В кн.: Антифосфолипидный синдром. М.: Литера. 2004. С. 278–298.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л. Иммунологические маркеры атеросклероза. В кн.: Антифосфолипидный синдром. М.: Литера. 2004. С. 278–298.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Malle E., De Beer F.C. Human serum amyloid A protein: a promising acute-phase reactant for clinical practice. Eur. J. Clin. Invest. 1996; 26: 427–435.</mixed-citation><mixed-citation xml:lang="en">Malle E., De Beer F.C. Human serum amyloid A protein: a promising acute-phase reactant for clinical practice. Eur. J. Clin. Invest. 1996; 26: 427–435.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Morrow D. L., Rifai N., Antman E.M. et al. Serum amyloid A predictive early mortality in acute coronary syndrome: a TIMI 11A sub study. Am. Coll. Cardiol. 2000; 35: 358–362.</mixed-citation><mixed-citation xml:lang="en">Morrow D. L., Rifai N., Antman E.M. et al. Serum amyloid A predictive early mortality in acute coronary syndrome: a TIMI 11A sub study. Am. Coll. Cardiol. 2000; 35: 358–362.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Biasucci L., Liuzzo G., Grillo R. et al. Elevated levels of C-reactive protein at discharge in patient with unstable angina predict recurrent instability. Circulation. 1999; 99: 855–860.</mixed-citation><mixed-citation xml:lang="en">Biasucci L., Liuzzo G., Grillo R. et al. Elevated levels of C-reactive protein at discharge in patient with unstable angina predict recurrent instability. Circulation. 1999; 99: 855–860.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Насонова В.А., Бунчук Н.В. Ревматические болезни. Руководство по внутренним болезням. М.: Медицина. 1997.</mixed-citation><mixed-citation xml:lang="en">Насонова В.А., Бунчук Н.В. Ревматические болезни. Руководство по внутренним болезням. М.: Медицина. 1997.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">De Bendetti F., Massa M., Robbioni P. et al Correlation of serum interleukin-6 levels with joint involvement and trombocytosis in systemic juvenile rheumatoid arthritis. Arthritis Rheum. 1991; 34: 1158–1163.</mixed-citation><mixed-citation xml:lang="en">De Bendetti F., Massa M., Robbioni P. et al Correlation of serum interleukin-6 levels with joint involvement and trombocytosis in systemic juvenile rheumatoid arthritis. Arthritis Rheum. 1991; 34: 1158–1163.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Rooney M., David J., Symmons J. et al. Inflammatory cytokine responses in juvenile chronic arthritis. Br. J. Rheumatol. 1995; 34: 454–460.</mixed-citation><mixed-citation xml:lang="en">Rooney M., David J., Symmons J. et al. Inflammatory cytokine responses in juvenile chronic arthritis. Br. J. Rheumatol. 1995; 34: 454–460.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">De Bendetti F., Massa M., Pignatti P. et al. Serum soluble interleukin-6 receptor and interleukin-6 receptor complex in systemic juvenile rheumatoid arthritis. J. Clin. Invest. 1994; 93: 2114–2119.</mixed-citation><mixed-citation xml:lang="en">De Bendetti F., Massa M., Pignatti P. et al. Serum soluble interleukin-6 receptor and interleukin-6 receptor complex in systemic juvenile rheumatoid arthritis. J. Clin. Invest. 1994; 93: 2114–2119.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Peake N.J., Khawaja K., Myeis A. Interleukin–6 signalling in juvenile rheumatoid arthritis is limited by proteolytically cleaved soluble interleukin–6 receptor. Rheumatology. 2006; 45 (12): 1485–1489.</mixed-citation><mixed-citation xml:lang="en">Peake N.J., Khawaja K., Myeis A. Interleukin–6 signalling in juvenile rheumatoid arthritis is limited by proteolytically cleaved soluble interleukin–6 receptor. Rheumatology. 2006; 45 (12): 1485–1489.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Keul R., Heinrich P.C., Muller-Newen G. et al. A possible role of soluble interleukin–6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis. Cytokine. 1998; 10: 729.</mixed-citation><mixed-citation xml:lang="en">Keul R., Heinrich P.C., Muller-Newen G. et al. A possible role of soluble interleukin–6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis. Cytokine. 1998; 10: 729.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ridker P.M., Rifai N., Stampfer M.J., Hennekens C.H. Plasma concentration of interleukin-6 and the risk of feature myocardial infarction among apparently healthy men. Circulation. 2000; 101: 1767–1772.</mixed-citation><mixed-citation xml:lang="en">Ridker P.M., Rifai N., Stampfer M.J., Hennekens C.H. Plasma concentration of interleukin-6 and the risk of feature myocardial infarction among apparently healthy men. Circulation. 2000; 101: 1767–1772.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Harris T.B., Ferrucci I., Traxy R.P. et al. Associations of elevated interleukin-6 and C-protein levels with mortality in the elderly. Am. J. Med. 1999; 106: 506–512.</mixed-citation><mixed-citation xml:lang="en">Harris T.B., Ferrucci I., Traxy R.P. et al. Associations of elevated interleukin-6 and C-protein levels with mortality in the elderly. Am. J. Med. 1999; 106: 506–512.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Lee W.Y., Allison M.A., Kim D.J. Association of interleukin–6 and C–reactive protein with subclinical carotid atherosclerosis (the Rancho Bernardo Study). Am. J. Cardiol. 2007; 99 (1): 99-102.</mixed-citation><mixed-citation xml:lang="en">Lee W.Y., Allison M.A., Kim D.J. Association of interleukin–6 and C–reactive protein with subclinical carotid atherosclerosis (the Rancho Bernardo Study). Am. J. Cardiol. 2007; 99 (1): 99-102.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Rooney M., Varsani H., Martin K. et al. Tumour necrosis factor alpha and its soluble receptorsin juvenile chronic arthritis. Rheumatology (Oxford). 2000; 39: 432–438.</mixed-citation><mixed-citation xml:lang="en">Rooney M., Varsani H., Martin K. et al. Tumour necrosis factor alpha and its soluble receptorsin juvenile chronic arthritis. Rheumatology (Oxford). 2000; 39: 432–438.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gattorno M., Picco P., Buoncompagni A. et al. Serum p55 and p75 tumour necrosis factor receptors as markers of disease activity in juvenile chronic arthritis. Ann. Rheum. Dis. 1996; 55: 243.</mixed-citation><mixed-citation xml:lang="en">Gattorno M., Picco P., Buoncompagni A. et al. Serum p55 and p75 tumour necrosis factor receptors as markers of disease activity in juvenile chronic arthritis. Ann. Rheum. Dis. 1996; 55: 243.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Abramson S.B., Amin A. Blocking the effects of ИЛ 1 in rheumatoil arthritis protects bone and cartilage. Rheumatology (Oxford). 2002; 41 (9): 972–980.</mixed-citation><mixed-citation xml:lang="en">Abramson S.B., Amin A. Blocking the effects of ИЛ 1 in rheumatoil arthritis protects bone and cartilage. Rheumatology (Oxford). 2002; 41 (9): 972–980.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Cassidy P., Lindsley L. Textbook of Pediatric Rheumatology. 5th edition. USA. 2006.</mixed-citation><mixed-citation xml:lang="en">Cassidy P., Lindsley L. Textbook of Pediatric Rheumatology. 5th edition. USA. 2006.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Kavanaugh A. Anakinra (interleukin-1 receptor antagonist) has positive effects on function and quality of life in patient with rheumatoid arthritis. Adv. Ther. 2006; 23 (2): 208–217.</mixed-citation><mixed-citation xml:lang="en">Kavanaugh A. Anakinra (interleukin-1 receptor antagonist) has positive effects on function and quality of life in patient with rheumatoid arthritis. Adv. Ther. 2006; 23 (2): 208–217.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Weiss G., Willei J., Kiechl S. et al. Increased concentrations of neopterin in carotid atherosclerosis. Atherosclerosis. 1994; 106: 263–271.</mixed-citation><mixed-citation xml:lang="en">Weiss G., Willei J., Kiechl S. et al. Increased concentrations of neopterin in carotid atherosclerosis. Atherosclerosis. 1994; 106: 263–271.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Erren M., Reinecke H., Junker R. et al. Systemic inflammatory parameters in patients with atherosclerosis of the coronary and peripheral artheries. Artherioscler. Thromb. Vasc. Biol. 1999; 19: 338–339.</mixed-citation><mixed-citation xml:lang="en">Erren M., Reinecke H., Junker R. et al. Systemic inflammatory parameters in patients with atherosclerosis of the coronary and peripheral artheries. Artherioscler. Thromb. Vasc. Biol. 1999; 19: 338–339.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Garica-Moll N., Coccolo F., Cole D et al. Serum neopterin and complexes stenosis morphology in patients with unstable angina. Artherioscler. Thromb. Vasc. Biol. 2000; 35: 956–962.</mixed-citation><mixed-citation xml:lang="en">Garica-Moll N., Coccolo F., Cole D et al. Serum neopterin and complexes stenosis morphology in patients with unstable angina. Artherioscler. Thromb. Vasc. Biol. 2000; 35: 956–962.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Gurfinkel E.P., Scirica B.M., Borovich G. et al Serum neopterin levels and the angiographic extent of coronary arterial narrowing in instable angina pectoris and non-Q wave acute myocardial infarction. Am. J. Cardiol. 1999; 83: 515–518.</mixed-citation><mixed-citation xml:lang="en">Gurfinkel E.P., Scirica B.M., Borovich G. et al Serum neopterin levels and the angiographic extent of coronary arterial narrowing in instable angina pectoris and non-Q wave acute myocardial infarction. Am. J. Cardiol. 1999; 83: 515–518.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е.Л., Самсонов М.Ю., Tilz G., Fuhs D. Неоптерин — новый иммунологический маркер аутоиммунных ревматических заболеваний. Клиническая медицина. 2000; 8: 43–46.</mixed-citation><mixed-citation xml:lang="en">Насонов Е.Л., Самсонов М.Ю., Tilz G., Fuhs D. Неоптерин — новый иммунологический маркер аутоиммунных ревматических заболеваний. Клиническая медицина. 2000; 8: 43–46.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Moncada S., Palmer R.M.J., Higgs E.A. Biosynthesis of nitric oxide from L–arginine: a pathway for the regulation of cell function and communication. Biochem. Pharmacol. 1989; 38: 1709–1715.</mixed-citation><mixed-citation xml:lang="en">Moncada S., Palmer R.M.J., Higgs E.A. Biosynthesis of nitric oxide from L–arginine: a pathway for the regulation of cell function and communication. Biochem. Pharmacol. 1989; 38: 1709–1715.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Palmer R.M.J., Mineau F., Ranger P et al. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium dependent relaxation. Biochem. Biophys. Res. Comm. 1988; 153: 1251–1256.</mixed-citation><mixed-citation xml:lang="en">Palmer R.M.J., Mineau F., Ranger P et al. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium dependent relaxation. Biochem. Biophys. Res. Comm. 1988; 153: 1251–1256.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Горрен А.К.Ф., Майер Б. Универсальная и комплексная энзимология синтазы азота // Обзор. Биохимия. 1998; 7: 870–880.</mixed-citation><mixed-citation xml:lang="en">Горрен А.К.Ф., Майер Б. Универсальная и комплексная энзимология синтазы азота // Обзор. Биохимия. 1998; 7: 870–880.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Das P., Schurman D.J., Lane S.R. Nitric oxide and G proteins mediate the response of bovine articular chondrocytes to fluid-induced shear. J. Orthop. Res. 1997; 15: 87–93.</mixed-citation><mixed-citation xml:lang="en">Das P., Schurman D.J., Lane S.R. Nitric oxide and G proteins mediate the response of bovine articular chondrocytes to fluid-induced shear. J. Orthop. Res. 1997; 15: 87–93.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Lotz M., Bober L., Narula S. et al ИЛ 17 promotes cartilage degradation (abstract). Arth. Rheum. 1996; 39: 120.</mixed-citation><mixed-citation xml:lang="en">Lotz M., Bober L., Narula S. et al ИЛ 17 promotes cartilage degradation (abstract). Arth. Rheum. 1996; 39: 120.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Rediske J., Koehne C., Zhang B. et al. Inducible production of nitric oxide by articular cell types. Osteoarthrit. Cart. 1994; 2: 199–206.</mixed-citation><mixed-citation xml:lang="en">Rediske J., Koehne C., Zhang B. et al. Inducible production of nitric oxide by articular cell types. Osteoarthrit. Cart. 1994; 2: 199–206.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Charles I.S., Palmer R.M., Hickery M.S. et al. Cloning, characterization and expression of cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Nat. Acad. Sci. 1993; 90: 11419–11423.</mixed-citation><mixed-citation xml:lang="en">Charles I.S., Palmer R.M., Hickery M.S. et al. Cloning, characterization and expression of cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc. Nat. Acad. Sci. 1993; 90: 11419–11423.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Maier R., Bilbe G., Rediske J. et al. Inducible nitric oxide syntase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression. Biochem. Biophys. Acta. 1994; 1208: 145–150.</mixed-citation><mixed-citation xml:lang="en">Maier R., Bilbe G., Rediske J. et al. Inducible nitric oxide syntase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression. Biochem. Biophys. Acta. 1994; 1208: 145–150.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Mendes A.F., Carvalho A.P., Caramona M.M. et al. Role of nitric oxide in activation of NF-kappa B, AP-1 and NOS II expression in articular chondrocytes. Inflamm. Res. 2002; 51 (7): 369–375.</mixed-citation><mixed-citation xml:lang="en">Mendes A.F., Carvalho A.P., Caramona M.M. et al. Role of nitric oxide in activation of NF-kappa B, AP-1 and NOS II expression in articular chondrocytes. Inflamm. Res. 2002; 51 (7): 369–375.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">McCartney-Francis N., Allen J.B., Mizel D.E. et al. Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med. 1993; 178: 149–154.</mixed-citation><mixed-citation xml:lang="en">McCartney-Francis N., Allen J.B., Mizel D.E. et al. Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med. 1993; 178: 149–154.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Stefanovic-Racic M., Meyers K., Meschter C. et al. N–monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis Rheum. 1994; 37: 1062–1069.</mixed-citation><mixed-citation xml:lang="en">Stefanovic-Racic M., Meyers K., Meschter C. et al. N–monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis Rheum. 1994; 37: 1062–1069.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Ialenti A., Moncada S., Di Rosa M. et al. Modulation of adjuvant arthritis by endogenous nitric oxide. Br. J. Pharmacol. 1993; 110: 701–706.</mixed-citation><mixed-citation xml:lang="en">Ialenti A., Moncada S., Di Rosa M. et al. Modulation of adjuvant arthritis by endogenous nitric oxide. Br. J. Pharmacol. 1993; 110: 701–706.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">van`t Hof R.J., Hocking L., Wright P.K. et al. Nitric oxide is a mediator of apoptosis in the rheumatoid joint. Rheumatology. 2000; 39: 1004–1008.</mixed-citation><mixed-citation xml:lang="en">van`t Hof R.J., Hocking L., Wright P.K. et al. Nitric oxide is a mediator of apoptosis in the rheumatoid joint. Rheumatology. 2000; 39: 1004–1008.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Veihelmann A., Hofbauer A., Krombach F. et al. Differencial function of nifric oxide in murine antigen-induced arthritis. Rheumatology. 2002; 41: 509–517.</mixed-citation><mixed-citation xml:lang="en">Veihelmann A., Hofbauer A., Krombach F. et al. Differencial function of nifric oxide in murine antigen-induced arthritis. Rheumatology. 2002; 41: 509–517.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Ling S., Lai A., Borschukova O. et al. Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope. Arthritis. Rheum. 2006; 54 (11): 3423–3432.</mixed-citation><mixed-citation xml:lang="en">Ling S., Lai A., Borschukova O. et al. Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope. Arthritis. Rheum. 2006; 54 (11): 3423–3432.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Holoshitz J., Ling S. et al. Nitric oxide signaling triggered by the rheumatoid arthritis shared epitope: a new paradigm for MHC disease association? Ann. N.Y. Acad. Sci. 2007; 1110: 73–83.</mixed-citation><mixed-citation xml:lang="en">Holoshitz J., Ling S. et al. Nitric oxide signaling triggered by the rheumatoid arthritis shared epitope: a new paradigm for MHC disease association? Ann. N.Y. Acad. Sci. 2007; 1110: 73–83.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Bica B.E., Gomes N.M., Fernandes P.D. et al. Nitric oxide levels and the severity of juvenile idiopathic arthritis. Rheumatol. Int. 2007; 27 (9): 819–825.</mixed-citation><mixed-citation xml:lang="en">Bica B.E., Gomes N.M., Fernandes P.D. et al. Nitric oxide levels and the severity of juvenile idiopathic arthritis. Rheumatol. Int. 2007; 27 (9): 819–825.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Braumvald E. Shattuck lecture cardiovascular medicine at the turn of millennium: triumph, concerns, and opportunities. N. Engl. J. Med. 1997; 337: 1360–1369.</mixed-citation><mixed-citation xml:lang="en">Braumvald E. Shattuck lecture cardiovascular medicine at the turn of millennium: triumph, concerns, and opportunities. N. Engl. J. Med. 1997; 337: 1360–1369.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е. Л. Атеротромбоз при ревматических заболеваниях: анализ патогенеза. Терапевтический архив. 1998; 9: 95–98.</mixed-citation><mixed-citation xml:lang="en">Насонов Е. Л. Атеротромбоз при ревматических заболеваниях: анализ патогенеза. Терапевтический архив. 1998; 9: 95–98.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Shwager I., Jungi T.W. Effect of human recombinant cytokines of the induction of macrophage procoagulant activity. Blood. 1994; 83: 152–160.</mixed-citation><mixed-citation xml:lang="en">Shwager I., Jungi T.W. Effect of human recombinant cytokines of the induction of macrophage procoagulant activity. Blood. 1994; 83: 152–160.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
