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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vsp-1457</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ РАСТВОРИМЫХ РЕЦЕПТОРОВ К ФНО ? В ТЕРАПИИ ЮВЕНИЛЬНЫХ АРТРИТОВ</article-title><trans-title-group xml:lang="en"><trans-title>ASPECTS OF TREATMENT OF JUVENILE ARTHRITIS WITH SOLUBLE RECEPTORS TO TNF</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Е.И.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexeeva</surname><given-names>E.I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Валиева</surname><given-names>С.И.</given-names></name><name name-style="western" xml:lang="en"><surname>Valieva</surname><given-names>S.I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>Р.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>R.V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бзарова</surname><given-names>Т.М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bzarova</surname><given-names>T.M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>05</day><month>11</month><year>2015</year></pub-date><volume>7</volume><issue>5</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>51</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алексеева Е., Валиева С., Денисова Р., Бзарова Т., 2008</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="ru">Алексеева Е., Валиева С., Денисова Р., Бзарова Т.</copyright-holder><copyright-holder xml:lang="en">Alexeeva E., Valieva S., Denisova R., Bzarova T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/1457">https://vsp.spr-journal.ru/jour/article/view/1457</self-uri><abstract/><trans-abstract xml:lang="en"><p>The theme of review is the results of treatment of rheumatic diseases in adults and children with blocker of TNF-α etanercept. The data from single, open-labeled and multicenter double blinded placebo-controlled studies of activity and safety of etanercept is presented in this article. The results of researches show high efficacy of etanercept in treatment of rheumatoid arthritis and ankylosing spondylitis in children and adults. Besides high activity etanercept is one of the safest blockers of TNF-α in pediatric and adult practice.Key words: children, juvenile rheumatoid arthritis, treatment, etanercept.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.И., Литвицкий П.Ф. Ювенильный ревматоидный артрит: этиология, патогенез, клиника, алгоритмы диагностики и лечения. М.: ВЕДИ. 2007. 368 с.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е.И., Литвицкий П.Ф. Ювенильный ревматоидный артрит: этиология, патогенез, клиника, алгоритмы диагностики и лечения. 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