vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v15i2.1534vsp-1607Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESСвязь характеристик некомпактного слоя миокарда с риском наступления летального исхода и развития тромботических осложнений при дилатационном фенотипе некомпактного миокарда у детей: результаты когортного исследованияCorrelation of Non-Compact Myocardial Layer Characteristics With the Risk of Death and Thrombotic Complications in Dilated Phenotype of Non-Compact Myocardium in Children: Cohort Study ResultsУмароваМ. К.UmarovaM. K.

аспирант кардиологического отделения НЦЗД Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-04-90

u.malika@gmail.comБасаргинаЕ. Н.BasarginaYe. N.СильноваИ. В.SilnovaI. V.Научный центр здоровья детей, Москва, Российская ФедерацияРоссияScientific Centre of Children’s Health, Moscow, Russian FederationRussian FederationНаучный центр здоровья детей, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, Москва, Российская ФедерацияРоссияScientific Centre of Children’s Health, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Moscow, Russian FederationRussian Federation201601062016152161167Copyright © Умарова М.К., Басаргина Е.Н., Сильнова И.В., 20162016Умарова М.К., Басаргина Е.Н., Сильнова И.В.Umarova M.K., Basargina Y.N., Silnova I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1607

Некомпактный миокард — форма кардиомиопатии, которая характеризуется наличием аномального трабекулярного (некомпактного) слоя миокарда желудочков. Связь выраженности некомпактного слоя миокарда с особенностями течения и исходом болезни остается неясной.

Цель исследования

Цель исследования: изучить связь величины соотношения толщины некомпактного и компактного слоев миокарда (НК/К), а также числа некомпактных сегментов левого желудочка (ЛЖ) сердца с риском летального исхода и тромботических осложнений у детей с дилатационным фенотипом некомпактного миокарда.

Методы

Методы: представлены результаты проспективного когортного исследования, в которое включали детей, госпитализированных в специализированный стационар с октября 2011 по май 2015 г. Наличие некомпактного миокарда устанавливали на основании результатов эхокардиографии.

Результаты

Результаты: в исследование включено 48 детей с некомпактным миокардом и ремоделированием миокарда ЛЖ по дилатационному фенотипу. Летальный исход через 19 (8; 61) мес с момента обнаружения изменений со стороны сердца наступил в 11 (23%) случаях. Развитие тромботических осложнений (кардиоэмболия, внутрисосудистый тромбоз до или в ходе наблюдения) зафиксировано у 8 (17%) детей. Риск наступления смерти и развития тромботических осложнений не был связан с величиной НК/К и числом некомпактных сегментов ЛЖ.

Заключение

Заключение: величины соотношения НК/К и числа некомпактных сегментов миокарда ЛЖ не позволяют прогнозировать течение болезни у детей с дилатационным фенотипом некомпактного миокарда в отношении развития тромботических осложнений и наступления летального исхода.

Background

Background: Non-compact myocardium is a form of cardiomyopathy, which is characterized by an abnormal trabecular (non-compact) layer of the ventricular myocardium. The correlation between the severity of a non-compact myocardial layer and peculiarities of course and outcome of the disease remains unclear.

Objective

Objective: Our aim was to examine the relationship of the ratio value of the non-compact and compact myocardial layer (NC/C) thickness, as well as of the number of non-compact segments of the left ventricle (LV) of the heart with the risk of death and thrombotic complications in children with dilated phenotype of non-compact myocardium.

Methods

Methods: The results of a prospective cohort study, which included children hospitalized to a specialized hospital from October 2011 to May 2015, are presented. The presence of non-compact myocardium was established on the basis of echocardiography results.

Results

Results: The study included 48 children with non-compact myocardium and LV myocardium remodelling on the dilatation phenotype. Fatal outcome in 19 (8; 61) months from the date of detection of heart changes occurred in 11 (23%) cases. The development of thrombotic complications (cardioembolism, intravascular thrombosis before or during the observation) is recorded in 8 (17%) children. The risk of death and thrombotic complications did not depend on the NC/C value and the number of non-compact LV segments.

Conclusion

Conclusion: The value of the ratio of NC/C and the number of non-compact LV myocardial segments does not allow to predict the course of the disease in children with dilated phenotype of non-compact myocardium in relation to the development of thrombotic complications and occurrence of fatal outcome.

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The authors declare that there are no conflicts of interest present.