vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v13i4.1079vsp-162Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWВОЗМОЖНОСТИ ИСПОЛЬЗОВАНИЯ ЛАКТОФЕРРИНА ЧЕЛОВЕКА В ПЕДИАТРИЧЕСКОЙ ПРАКТИКЕAPPLICABILITY OF A HUMAN LACTOFERRIN IN PEDIATRIC PRACTICEБоровикТ. Э.BorovikT. E.borovik@nczd.ruЯцыкГ. В.YatsykG. V.borovik@nczd.ruНамазова-БарановаЛ. С.Namazova-BaranovaL. S.namazova@nczd.ruЗвонковаН. Г.ZvonkovaN. G.borovik@nczd.ruСемёноваН. Н.SemenovaN. N.borovik@nczd.ruЛукояноваО. Л.LukoyanovaО. L.borovik@nczd.ruСадчиковП. Е.SadchikovP. E.borovik@nczd.ruГольдманИ. Л.Gol'dmanI. L.borovik@nczd.ruСадчиковаЕ. Р.SadchikovaE. R.borovik@nczd.ruБеляеваИ. А.BelyaevaI. А.borovik@nczd.ruБушуеваТ. В.BushuevaT. V.borovik@nczd.ruНаучный центр здоровья детей, МоскваРоссияScientific Centre of Children HealthRussian FederationНаучный центр здоровья детей, Москва Первый Московский государственный медицинский университет им. И.М. Сеченова; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова, МоскваРоссияScientific Centre of Children Health I.M. Sechenov First Moscow State Medical University; Pirogov Russian National Research Medical University, MoscowRussian FederationИнститут биологии гена РАН, МоскваРоссияInstitute of Gene Biology of the Russian Academy of Sciences, MoscowRussian Federation201402082014134Вопросы современной педиатрии1219Copyright © Боровик Т.Э., Яцык Г.В., Намазова-Баранова Л.С., Звонкова Н.Г., Семёнова Н.Н., Лукоянова О.Л., Садчиков П.Е., Гольдман И.Л., Садчикова Е.Р., Беляева И.А., Бушуева Т.В., 20142014Боровик Т.Э., Яцык Г.В., Намазова-Баранова Л.С., Звонкова Н.Г., Семёнова Н.Н., Лукоянова О.Л., Садчиков П.Е., Гольдман И.Л., Садчикова Е.Р., Беляева И.А., Бушуева Т.В.Borovik T.E., Yatsyk G.V., Namazova-Baranova L.S., Zvonkova N.G., Semenova N.N., Lukoyanova О.L., Sadchikov P.E., Gol'dman I.L., Sadchikova E.R., Belyaeva I.А., Bushueva T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/162

В обзоре литературных данных представлены современные сведения об эффективности и безопасности рекомбинантного человеческого лактоферрина (чЛф) и перспективах его использования в педиатрической практике. Отмечены уникальные противоинфекционные свойства биологически активного белка чЛф, его высокая антимикробная, противовирусная, противогрибковая и антипаразитарная активность. Проанализирована способность стимулировать естественный иммунитет, взаимодействовать с другими антимикробными пептидами, в частности с лизоцимом и секреторным ингибитором лейкопротеазы. В связи с этим указывается на перспективность применения чЛф в лечении недоношенных и маловесных детей, больных с хронической недостаточностью питания с целью профилактики инфекционных заболеваний и коррекции воспалительных изменений в организме ребенка, в т. ч. при острых респираторных вирусных и кишечных инфекциях у детей. Целесообразным является применение чЛф в хирургической практике для уменьшения степени выраженности острого провоспалительного ответа, а также для профилактики инфекционных осложнений, особенно после полостных операций, в комплексном лечении детей с тяжелой генерализованной инфекцией и полиорганной недостаточностью, для профилактики внутрибольничных нозокомиальных инфекций в детских стационарах.

 

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The authors declare that there are no conflicts of interest present.