vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v15i5.1618vsp-1668Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWНЕЙРОГЕНЕТИЧЕСКИЕ АСПЕКТЫ ГИПОКCИЧЕСКИ-ИШЕМИЧЕСКИХ ПЕРИНАТАЛЬНЫХ ПОРАЖЕНИЙ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫNEUROGENETIC ASPECTS OF PERINATAL HYPOXIC-ISCHEMIC AFFECTIONS OF THE CENTRAL NERVOUS SYSTEMКаркашадзеГ. А.KarkashadzeGeorge A.

Каркашадзе Георгий Арчилович - кандидат медицинских наук, заведующий отделением когнитивной педиатрии НИИ педиатрии НЦЗД.

karkga@mail.ruСавостьяновК. В.SavostianovKirill V.МакароваС. Г.MakarovaSvetlana G.Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.МасловаO. И.MaslovaOlga I.ЯцыкГ. В.YatsykGalina V.Научный центр здоровья детейРоссияScientific Center of Children’s HealthRussian FederationНаучный центр здоровья детей; Первый Московский государственный медицинский университет имени И.М. СеченоваРоссияScientific Center of Children’s Health; Sechenov First Moscow State Medical UniversityRussian FederationНаучный центр здоровья детей; Первый Московский государственный медицинский университет имени И.М. Сеченова; Российский национальный исследовательский медицинский университет имени Н.И. ПироговаРоссияScientific Center of Children’s Health; Sechenov First Moscow State Medical University; Pirogov Russian National Medical Research UniversityRussian Federation201624112016155440451Copyright © Каркашадзе Г.А., Савостьянов К.В., Макарова С.Г., Намазова-Баранова Л.С., Маслова O.И., Яцык Г.В., 20162016Каркашадзе Г.А., Савостьянов К.В., Макарова С.Г., Намазова-Баранова Л.С., Маслова O.И., Яцык Г.В.Karkashadze G.A., Savostianov K.V., Makarova S.G., Namazova-Baranova L.S., Maslova O.I., Yatsyk G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1668

Neurogenetics is a thriving young science greatly contributing to the generally accepted concept of the brain development in health and disease. Thereby; scientists are not only able to highlight new key points in traditional ideas about the origin of diseases; but also to completely rethink their view on the problem of pathology development. In particular; new data on neurogenetics of perinatal affections of the central nervous system (CNS) has appeared. Genetic factors in varying degrees affect perinatal hypoxic-ischemic CNS affections.

Prematurity determination stays the most studied among them. Nevertheless; there is increasing evidence of significant epigenetic regulations of neuro-expression caused by hypoxia; malnutrition of a pregnant woman; stress; smoking; alcohol; drugs that either directly pathologically affect the developing brain; or form a brain phenotype sensitive to a perinatal CNS affection. New data obliges to change the approaches to prevention of perinatal CNS affections.

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The authors declare that there are no conflicts of interest present.