vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v15i5.1619vsp-1669Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWПОТЕНЦИАЛЬНАЯ РОЛЬ СЫВОРОТОЧНОГО ПЕРИОСТИНА В РАННЕЙ ДИАГНОСТИКЕ БРОНХИАЛЬНОЙ АСТМЫ У ДЕТЕЙPOTENTIAL ROLE OF SERUM PERIOSTIN IN THE EARLY DETECTION OF BRONCHIAL ASTHMA IN CHILDRENСоботюкН. В.SobotyukNickolai V.

Соботюк Николай Васильевич - заслуженный врач Российской Федерации; профессор кафедры педиатрии ОмГМУ.

sobotyuk@mail.ruГапоненкоВ. П.GaponenkoValentina P.БочанцевС. В.BochantsevSergei V.ГолочаловаС. А.GolochalovaSvetlana A.СазоноваИ. В.SazonovaIrina V.ХарламоваТ. Н.КharlamovaTatiana N.Омский государственный медицинский университетРоссияOmsk State Medical UniversityRussian FederationГородская детская клиническая больница № 2 имени В.П. БисяринойРоссияBisyarina Municipal Children's Clinical Hospital № 2Russian Federation201624112016155452456Copyright © Соботюк Н.В., Гапоненко В.П., Бочанцев С.В., Голочалова С.А., Сазонова И.В., Харламова Т.Н., 20162016Соботюк Н.В., Гапоненко В.П., Бочанцев С.В., Голочалова С.А., Сазонова И.В., Харламова Т.Н.Sobotyuk N.V., Gaponenko V.P., Bochantsev S.V., Golochalova S.A., Sazonova I.V., Кharlamova T.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1669

Респираторные вирусные инфекции у детей раннего и дошкольного возраста часто сопровождаются повторными эпизодами свистящего дыхания и с ними связывают повышенный риск развития бронхиальной астмы. Механизмы связи вирусной инфекции с последующим развитием аллергического воспаления в респираторном тракте изучены недостаточно. К сожалению несмотря на наличие такой связи на основе клинических симптомов проблематично прогнозировать реализацию риска. В качестве предикторов аллергического воспаления в дыхательных путях было предложено определение оксида азота в выдыхаемом воздухе числа эозинофилов в периферической крови и бронхоальвеолярной лаважной жидкости а также IgE но эти суррогатные маркеры у пациентов в т. ч. у детей с бронхиальной астмой имеют умеренную диагностическую точность. Их использование в качестве маркера эозинофилии дыхательных путей может обусловить значительное количество ложноположительных и ложноотрицательных результатов. Исследования последних лет показали что определение уровня сывороточногопериостина с большей точностью подтверждает эозинофильное воспаление дыхательных путей. Обсуждается возможность исследования этого маркера при различных вариантах свистящего дыхания у детей как возможного предиктора развития бронхиальной астмы с учетом его надежности стабильности и небольшой вариативности в определении эозинофильного воспаления в дыхательных путях при симптомах бронхиальной обструкции.

Respiratory viral infections in infants and preschool children are often accompanied by repeated episodes of wheezing; which is associated with an increased risk of asthma development. Mechanisms of connection between a viral infection and the subsequent development of allergic inflammation in the respiratory tract are insufficiently studied. Unfortunately; despite the existence of such connection; it is difficult to predict the risk occurrence on the basis of clinical symptoms. Determination of nitrogen oxide in the exhaled air; of the number of eosinophils in the peripheral blood and of bronchoalveolar lavage fluid as well as of IgE was suggested as predictors of allergic inflammation in the airways. But these surrogate markers in patients including children with asthma have a moderate diagnostic accuracy. Their use as a marker of airway eosinophilia can cause a significant amount of false-positive and false-negative results. Recent studies have shown that determination of serum periostin more accurately confirms eosinophilic airway inflammation. The possibility to study this marker in different variants of wheezing in children as a possible predictor of asthma development is discussed based on its reliability; stability and a small variation in determination of eosinophilic inflammation in the airways with symptoms of bronchial obstruction.

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The authors declare that there are no conflicts of interest present.