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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/vsp.v15i6.1653</article-id><article-id custom-type="elpub" pub-id-type="custom">vsp-1694</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>Терапия острых респираторных инфекций у детей с позиции доказательной медицины</article-title><trans-title-group xml:lang="en"><trans-title>Evidence-Based Treatment of Acute Respiratory Infections in Children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондюрина</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondiurina</surname><given-names>Elena G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск, Российская Федерация</p></bio><bio xml:lang="en"><p>Novosibirsk, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0344-9412</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зеленская</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zelenskaia</surname><given-names>Vera V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, доцент, профессор кафедры педиатрии ФПКиППВ Новосибирского государственного медицинского университета Адрес: 630091, Новосибирск, Красный проспект, д. 52, тел.: +7 (3832) 229-10-83 </p></bio><bio xml:lang="en"><p>Novosibirsk, Russian Federation</p></bio><email xlink:type="simple">v.zelenskaya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Новосибирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>29</day><month>12</month><year>2016</year></pub-date><volume>15</volume><issue>6</issue><fpage>568</fpage><lpage>575</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кондюрина Е.Г., Зеленская В.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Кондюрина Е.Г., Зеленская В.В.</copyright-holder><copyright-holder xml:lang="en">Kondiurina E.G., Zelenskaia V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/1694">https://vsp.spr-journal.ru/jour/article/view/1694</self-uri><abstract><p>Терапия острых респираторных инфекций (ОРИ) у детей остается важной задачей практического здравоохранения. В настоящее время проблема выбора лекарственных средств и полипрагмазия при ОРИ является весьма актуальной. В статье рассматриваются вопросы применения лекарственных средств при этиотропной и симптоматической терапии ОРИ у детей, особенности назначения муколитической терапии с позиций доказательной медицины.</p></abstract><trans-abstract xml:lang="en"><p>Treatment of acute respiratory infections (ARI) in children is an important task of practical healthcare. Currently, the problem of choosing medicines and polypharmacy at ARI is very relevant. This article considers the issues of using medicines during a causal and symptomatic treatment of ARI in children, and peculiarities of the mucolytic evidence-based therapy order.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>острые респираторные инфекции</kwd><kwd>муколитические препараты.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>acute respiratory infections</kwd><kwd>mucolytic agents</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dorland’s illustrated medical dictionary. 27th ed. Philadelphia, Pa.: W. B. Saunders Co.; 1988.</mixed-citation><mixed-citation xml:lang="en">Dorland’s illustrated medical dictionary. 27th ed. Philadelphia, Pa.: W. B. Saunders Co.; 1988.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2015 году. Государственный доклад. — М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека; 2016. — 200 с. [O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Rossiiskoi Federatsii v 2015 godu. Gosudarstvennyi doklad. Moscow: Federal’naya sluzhba po nadzoru v sfere zashchity prav potrebitelei i blagopoluchiya cheloveka; 2016. 200 p. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2015 году. Государственный доклад. — М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека; 2016. — 200 с. [O sostoyanii sanitarno-epidemiologicheskogo blagopoluchiya naseleniya v Rossiiskoi Federatsii v 2015 godu. Gosudarstvennyi doklad. Moscow: Federal’naya sluzhba po nadzoru v sfere zashchity prav potrebitelei i blagopoluchiya cheloveka; 2016. 200 p. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Бокова Т.А. Острые респираторные вирусные инфекции у детей с отягощенным аллергологическим фоном: современные аспекты терапии // Лечащий врач. — 2016. — № 4 — С. 10–71. [Bokova TA. Ostrye respiratornye virusnye infektsii u detei s otyagoshchennym allergologicheskim fonom: sovremennye aspekty terapii. Practitioner. 2016;(4):10–71. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Бокова Т.А. Острые респираторные вирусные инфекции у детей с отягощенным аллергологическим фоном: современные аспекты терапии // Лечащий врач. — 2016. — № 4 — С. 10–71. [Bokova TA. Ostrye respiratornye virusnye infektsii u detei s otyagoshchennym allergologicheskim fonom: sovremennye aspekty terapii. Practitioner. 2016;(4):10–71. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Яцышина С.Б., Спичак Т.В., Ким С.С. и др. Выявление респираторных вирусов и атипичных бактерий у больных пневмонией и здоровых детей за десятилетний период наблюдения // Педиатрия. Журнал им. Г.Н. Сперанского. — 2016. — Т. 95. — № 2 — С. 43–50. [Yatsyshina SB, Spichak TV, Kim SS, et al. Revealing of respiratory viruses and atypical bacteria in children with pneumonia and healthy children for ten years of observation. Pediatriia. 2016;95(2):43–50. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Яцышина С.Б., Спичак Т.В., Ким С.С. и др. Выявление респираторных вирусов и атипичных бактерий у больных пневмонией и здоровых детей за десятилетний период наблюдения // Педиатрия. Журнал им. Г.Н. Сперанского. — 2016. — Т. 95. — № 2 — С. 43–50. [Yatsyshina SB, Spichak TV, Kim SS, et al. Revealing of respiratory viruses and atypical bacteria in children with pneumonia and healthy children for ten years of observation. Pediatriia. 2016;95(2):43–50. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Liu YC, Post JC. Biofilms in pediatric respiratory and related infections. Curr Allergy Asthma Rep. 2009;9(6):449–455. doi: 10.1007/s11882-009-0066-6.</mixed-citation><mixed-citation xml:lang="en">Liu YC, Post JC. Biofilms in pediatric respiratory and related infections. Curr Allergy Asthma Rep. 2009;9(6):449–455. doi: 10.1007/s11882-009-0066-6.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchez C, Mende K, Beckius M, et al. Biofilm formation by clinical isolates and the implications in chronic infections. BMC Infect Dis. 2013;13:47. doi: 10.1186/1471-2334-13-47.</mixed-citation><mixed-citation xml:lang="en">Sanchez C, Mende K, Beckius M, et al. Biofilm formation by clinical isolates and the implications in chronic infections. BMC Infect Dis. 2013;13:47. doi: 10.1186/1471-2334-13-47.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Tikhomirova A, Kidd S. Haemophilus influenzae and Streptococcus pneumoniae: living together in a biofilm. Pathog Dis. 2013; 69(2):114–126. doi: 10.1111/2049-632X.12073.</mixed-citation><mixed-citation xml:lang="en">Tikhomirova A, Kidd S. Haemophilus influenzae and Streptococcus pneumoniae: living together in a biofilm. Pathog Dis. 2013; 69(2):114–126. doi: 10.1111/2049-632X.12073.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dalton T, Dowd S, Wolcott R, et al. An in vivo polymicrobial biofilm wound infection model to study interspecies interactions. PLoS One. 2011;6(11):e27317. doi: 10.1371/journal.pone.0027317.</mixed-citation><mixed-citation xml:lang="en">Dalton T, Dowd S, Wolcott R, et al. An in vivo polymicrobial biofilm wound infection model to study interspecies interactions. PLoS One. 2011;6(11):e27317. doi: 10.1371/journal.pone.0027317.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bjarnsholt T. The role of bacterial biofilms in chronic infections. APMIS. 2013;(136 Suppl):1–51. doi: 10.1111/apm.12099.</mixed-citation><mixed-citation xml:lang="en">Bjarnsholt T. The role of bacterial biofilms in chronic infections. APMIS. 2013;(136 Suppl):1–51. doi: 10.1111/apm.12099.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mietto C, Pinciroli R, Patel N, Berra L. Ventilator associated pneumonia: evolving definitions and preventive strategies. Respir Care. 2013;58(6):990–1007. doi: 10.4187/respcare.02380.</mixed-citation><mixed-citation xml:lang="en">Mietto C, Pinciroli R, Patel N, Berra L. Ventilator associated pneumonia: evolving definitions and preventive strategies. Respir Care. 2013;58(6):990–1007. doi: 10.4187/respcare.02380.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Aslam S, Darouiche R. Role of antibiofilm-antimicrobial agents in controlling device- related infections. Int J Artif Organs. 2011; 34(9):752–758. doi: 10.5301/ijao.5000024.</mixed-citation><mixed-citation xml:lang="en">Aslam S, Darouiche R. Role of antibiofilm-antimicrobial agents in controlling device- related infections. Int J Artif Organs. 2011; 34(9):752–758. doi: 10.5301/ijao.5000024.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Самсыгина Г.А. Современное лечение острых респираторных заболеваний у детей. Педиатрия. Журнал им. Г.Н. Сперанского. — 2013. — Т. 92. — № 3 — С. 38–42. [Samsygina GA. Sovremennoe lechenie ostrykh respiratornykh zabolevanii u detei. Pediatriia. 2013;92(3):38–42. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Самсыгина Г.А. Современное лечение острых респираторных заболеваний у детей. Педиатрия. Журнал им. Г.Н. Сперанского. — 2013. — Т. 92. — № 3 — С. 38–42. [Samsygina GA. Sovremennoe lechenie ostrykh respiratornykh zabolevanii u detei. Pediatriia. 2013;92(3):38–42. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцева О.В., Зайцева С.В. Лечение и профилактика острых респираторных инфекций у часто болеющих детей // Лечащий врач. — 2008. — № 8 — С. 53–57. [Zaitseva OV, Zaitseva SV. Lechenie i profilaktika ostrykh respiratornykh infektsii u chasto boleyushchikh detei. Practitioner. 2008;(8):53–57. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Зайцева О.В., Зайцева С.В. Лечение и профилактика острых респираторных инфекций у часто болеющих детей // Лечащий врач. — 2008. — № 8 — С. 53–57. [Zaitseva OV, Zaitseva SV. Lechenie i profilaktika ostrykh respiratornykh infektsii u chasto boleyushchikh detei. Practitioner. 2008;(8):53–57. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kobayashi H. Airway biofilms: implications for pathogenesis and therapy of respiratory tract infections. Treat Respir Med. 2005;4(4):241–253. doi: 10.2165/00151829-200504040- 00003.</mixed-citation><mixed-citation xml:lang="en">Kobayashi H. Airway biofilms: implications for pathogenesis and therapy of respiratory tract infections. Treat Respir Med. 2005;4(4):241–253. doi: 10.2165/00151829-200504040- 00003.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Таточенко В.К. ОРВИ и грипп у детей. Основные трудности диагностики и возможности рациональной терапии // Лечащий врач. — 2015. — № 9 — С. 32–36. [Tatochenko VK. ORVI i gripp u detei. Osnovnye trudnosti diagnostiki i vozmozhnosti ratsional’noi terapii. Practitioner. 2015;(9):32–36. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Таточенко В.К. ОРВИ и грипп у детей. Основные трудности диагностики и возможности рациональной терапии // Лечащий врач. — 2015. — № 9 — С. 32–36. [Tatochenko VK. ORVI i gripp u detei. Osnovnye trudnosti diagnostiki i vozmozhnosti ratsional’noi terapii. Practitioner. 2015;(9):32–36. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Учайкин В.Ф., Нисевич Н.И., Шамшева О.В. Инфекционные болезни у детей. — М.: ГЭОТАР-Медиа; 2013. — 688 с. [Uchaikin VF, Nisevich NI, Shamsheva OV. Infektsionnye bolezni u detei. Moscow: GEOTAR-Media; 2013. 688 p. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Учайкин В.Ф., Нисевич Н.И., Шамшева О.В. Инфекционные болезни у детей. — М.: ГЭОТАР-Медиа; 2013. — 688 с. [Uchaikin VF, Nisevich NI, Shamsheva OV. Infektsionnye bolezni u detei. Moscow: GEOTAR-Media; 2013. 688 p. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Arroll B, Kenealy T. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2005;(3):CD000247. doi: 10.1002/14651858.CD000247.pub2.</mixed-citation><mixed-citation xml:lang="en">Arroll B, Kenealy T. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2005;(3):CD000247. doi: 10.1002/14651858.CD000247.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Nyquist AC, Gonzales R, Steiner JF, Sande MA. Antibiotic prescribing for children with colds, upper respiratory infections, and bronchitis. JAMA. 1998;279(11):875–877. doi: 10.1001/jama.279.11.875.</mixed-citation><mixed-citation xml:lang="en">Nyquist AC, Gonzales R, Steiner JF, Sande MA. Antibiotic prescribing for children with colds, upper respiratory infections, and bronchitis. JAMA. 1998;279(11):875–877. doi: 10.1001/jama.279.11.875.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Pennie R. Prospective study of antibiotic prescribing for children. Can Fam Physician. 1998;44:1850–1856.</mixed-citation><mixed-citation xml:lang="en">Pennie R. Prospective study of antibiotic prescribing for children. Can Fam Physician. 1998;44:1850–1856.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Spurling GK, Del Mar CB, Dooley L, Foxlee R. Delayed antibiotics for respiratory infections. Cochrane Database Syst Rev. 2007;(3):CD004417. doi: 10.1002/14651858.CD004417.pub3.</mixed-citation><mixed-citation xml:lang="en">Spurling GK, Del Mar CB, Dooley L, Foxlee R. Delayed antibiotics for respiratory infections. Cochrane Database Syst Rev. 2007;(3):CD004417. doi: 10.1002/14651858.CD004417.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Jefferson T, Jones MA, Doshi P, et al. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev. 2014; (4):CD008965. doi: 10.1002/14651858.CD008965.pub4.</mixed-citation><mixed-citation xml:lang="en">Jefferson T, Jones MA, Doshi P, et al. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev. 2014; (4):CD008965. doi: 10.1002/14651858.CD008965.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Геппе Н.А., Теплякова Е.Д., Шульдяков А.А. и др. Инновации в педиатрии: оптимальный клинический эффект при лечении ОРВИ у детей препаратом комплексного действия // Педиатрия. Журнал им. Г.Н. Сперанского. — 2016. — Т. 95. — № 2 — С. 96–103. [Geppe NA, Teplyakova ED, Shuldyakov AA, et al. Innovations in pediatrics: the optimal clinical effec in acute respiratory viral infections treatment in children with complex action drug. Pediatriia. 2016;95(2):96–103. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Геппе Н.А., Теплякова Е.Д., Шульдяков А.А. и др. Инновации в педиатрии: оптимальный клинический эффект при лечении ОРВИ у детей препаратом комплексного действия // Педиатрия. Журнал им. Г.Н. Сперанского. — 2016. — Т. 95. — № 2 — С. 96–103. [Geppe NA, Teplyakova ED, Shuldyakov AA, et al. Innovations in pediatrics: the optimal clinical effec in acute respiratory viral infections treatment in children with complex action drug. Pediatriia. 2016;95(2):96–103. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Лихорадочные синдромы у детей: рекомендации по диагностике и лечению / Под общей ред. А.А. Баранова, В.К. Таточенко, М.Д. Бакрадзе. — М.: Союз педиатров России; 2011. — 228 с. [Likhoradochnye sindromy u detei: rekomendatsii po diagnostike i lecheniyu. Ed by Baranov A.A., Tatochenko V.K., Bakradze M.D. Moscow: Soyuz pediatrov Rossii; 2011. 228 p. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Лихорадочные синдромы у детей: рекомендации по диагностике и лечению / Под общей ред. А.А. Баранова, В.К. Таточенко, М.Д. Бакрадзе. — М.: Союз педиатров России; 2011. — 228 с. [Likhoradochnye sindromy u detei: rekomendatsii po diagnostike i lecheniyu. Ed by Baranov A.A., Tatochenko V.K., Bakradze M.D. Moscow: Soyuz pediatrov Rossii; 2011. 228 p. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Мелехина Е.В., Чугунова О.Я., Горелов А.В. и др. Тактика ведения детей с затяжным кашлем // Российский вестник перинатологии и педиатрии. — 2016. — № 1 — С. 110– 120. [Melekhina EV, Chugunova OL, Gorelov AV, et al. Management tactics for children with persistent cough. Rossiiskii vestnik perinatologii i pediatrii. 2016;61(1):110–120. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Мелехина Е.В., Чугунова О.Я., Горелов А.В. и др. Тактика ведения детей с затяжным кашлем // Российский вестник перинатологии и педиатрии. — 2016. — № 1 — С. 110– 120. [Melekhina EV, Chugunova OL, Gorelov AV, et al. Management tactics for children with persistent cough. Rossiiskii vestnik perinatologii i pediatrii. 2016;61(1):110–120. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">De Sutter AIM, Saraswat A, van Driel ML. Antihistamines for the common cold. Cochrane Database Syst Rev. 2015;(11):CD009345. doi: 10.1002/14651858.CD009345.pub2.</mixed-citation><mixed-citation xml:lang="en">De Sutter AIM, Saraswat A, van Driel ML. Antihistamines for the common cold. Cochrane Database Syst Rev. 2015;(11):CD009345. doi: 10.1002/14651858.CD009345.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Allan GM, Arroll B. Prevention and treatment of the common cold: making sense of the evidence. CMAJ. 2014;186(3):190–199. doi: 10.1503/cmaj.121442.</mixed-citation><mixed-citation xml:lang="en">Allan GM, Arroll B. Prevention and treatment of the common cold: making sense of the evidence. CMAJ. 2014;186(3):190–199. doi: 10.1503/cmaj.121442.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kim SY, Chang YJ, Cho HM, et al. Non-steroidal anti-inflammatory drugs for the common cold. Cochrane Database Syst Rev. 2015;(9):CD006362. doi: 10.1002/14651858.CD006362.pub4.</mixed-citation><mixed-citation xml:lang="en">Kim SY, Chang YJ, Cho HM, et al. Non-steroidal anti-inflammatory drugs for the common cold. Cochrane Database Syst Rev. 2015;(9):CD006362. doi: 10.1002/14651858.CD006362.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Li S, Yue J, Dong BR, et al. Acetaminophen (paracetamol) for the common cold in adults. Cochrane Database Syst Rev. 2013;(7):CD008800. doi: 10.1002/14651858.CD008800.pub2.</mixed-citation><mixed-citation xml:lang="en">Li S, Yue J, Dong BR, et al. Acetaminophen (paracetamol) for the common cold in adults. Cochrane Database Syst Rev. 2013;(7):CD008800. doi: 10.1002/14651858.CD008800.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Picon PD, Costa MB, da Veiga Picon R, et al. Symptomatic treatment of the common cold with a fixed-dose combination of paracetamol, chlorphenamine and phenylephrine: a randomized, placebo-controlled trial. BMC Infect Dis. 2013;13:556. doi: 10.1186/1471-2334- 13-556.</mixed-citation><mixed-citation xml:lang="en">Picon PD, Costa MB, da Veiga Picon R, et al. Symptomatic treatment of the common cold with a fixed-dose combination of paracetamol, chlorphenamine and phenylephrine: a randomized, placebo-controlled trial. BMC Infect Dis. 2013;13:556. doi: 10.1186/1471-2334- 13-556.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Deckx L, De Sutter AIM, Guo L, et al. Nasal decongestants in monotherapy for the common cold. Cochrane Database Syst Rev. 2016;(10):CD009612. doi: 10.1002/14651858.CD009612.pub2.</mixed-citation><mixed-citation xml:lang="en">Deckx L, De Sutter AIM, Guo L, et al. Nasal decongestants in monotherapy for the common cold. Cochrane Database Syst Rev. 2016;(10):CD009612. doi: 10.1002/14651858.CD009612.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Hayward G, Thompson MJ, Perera R, et al. Corticosteroids for the common cold. Cochrane Database Syst Rev. 2015;(10):CD008116. doi: 10.1002/14651858.CD008116.pub3.</mixed-citation><mixed-citation xml:lang="en">Hayward G, Thompson MJ, Perera R, et al. Corticosteroids for the common cold. Cochrane Database Syst Rev. 2015;(10):CD008116. doi: 10.1002/14651858.CD008116.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Hemila H. Thomas Chalmers, vitamin C and the common cold. J R Soc Med. 2016;109(2):46. doi: 10.1177/0141076815606279.</mixed-citation><mixed-citation xml:lang="en">Hemila H. Thomas Chalmers, vitamin C and the common cold. J R Soc Med. 2016;109(2):46. doi: 10.1177/0141076815606279.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013;(1):CD000980. doi: 10.1002/14651858.CD000980.pub4.</mixed-citation><mixed-citation xml:lang="en">Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013;(1):CD000980. doi: 10.1002/14651858.CD000980.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Goldman RD. Treating cough and cold: Guidance for caregivers of children and youth. Paediatr Child Health. 2011;16(9):564–566.</mixed-citation><mixed-citation xml:lang="en">Goldman RD. Treating cough and cold: Guidance for caregivers of children and youth. Paediatr Child Health. 2011;16(9):564–566.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Shields MD, Thavagnanam S. The difficult coughing child: prolonged acute cough in children. Cough. 2013;9:11. doi: 10.1186/1745-9974-9-11.</mixed-citation><mixed-citation xml:lang="en">Shields MD, Thavagnanam S. The difficult coughing child: prolonged acute cough in children. Cough. 2013;9:11. doi: 10.1186/1745-9974-9-11.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Singh M, Singh M. Heated, humidified air for the common cold. Cochrane Database Syst Rev. 2013;(6):CD001728. doi: 10.1002/14651858.CD001728.pub5.</mixed-citation><mixed-citation xml:lang="en">Singh M, Singh M. Heated, humidified air for the common cold. Cochrane Database Syst Rev. 2013;(6):CD001728. doi: 10.1002/14651858.CD001728.pub5.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014; (12):CD007094. doi: 10.1002/14651858.CD007094.pub4.</mixed-citation><mixed-citation xml:lang="en">Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014; (12):CD007094. doi: 10.1002/14651858.CD007094.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014; (11):CD001831. doi: 10.1002/14651858.CD001831.pub5.</mixed-citation><mixed-citation xml:lang="en">Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014; (11):CD001831. doi: 10.1002/14651858.CD001831.pub5.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Краснова Е.И., Проворова В.В., Гайнц О.В., Панасенко Л.М. Кашель у детей с острой респираторной инфекцией: когда назначать муколитики? // Лечащий врач. — 2015. — № 9 — С. 42–46. [Krasnova EI, Provorova VV, Gaints OV, Panasenko LM. Kashel’ u detei s ostroi respiratornoi infektsiei: kogda naznachat’ mukolitiki? Practitioner. 2015;(9):42–46. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Краснова Е.И., Проворова В.В., Гайнц О.В., Панасенко Л.М. Кашель у детей с острой респираторной инфекцией: когда назначать муколитики? // Лечащий врач. — 2015. — № 9 — С. 42–46. [Krasnova EI, Provorova VV, Gaints OV, Panasenko LM. Kashel’ u detei s ostroi respiratornoi infektsiei: kogda naznachat’ mukolitiki? Practitioner. 2015;(9):42–46. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцева О.В., Зайцева С.В., Локшина Э.Э. Особенности терапии кашля у детей // Вопросы практической педиатрии. — 2015. — № 1 — С. 68–74. [Zaytseva OV, Zaytseva SV, Lokshina EE. Specificities of cough therapy in children. Problems of practical pediatrics. 2015;10(1):68–74. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Зайцева О.В., Зайцева С.В., Локшина Э.Э. Особенности терапии кашля у детей // Вопросы практической педиатрии. — 2015. — № 1 — С. 68–74. [Zaytseva OV, Zaytseva SV, Lokshina EE. Specificities of cough therapy in children. Problems of practical pediatrics. 2015;10(1):68–74. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Геппе Н.А., Снегоцкая М.Н., Пенкина М.В. Алгоритм лечения кашля у детей // Фарматека. — 2014. — № 1 — С. 71–75. [Geppe NA, Snegotskaya MN, Penkina MV. Algoritm lecheniya kashlya u detei. Farmateka. 2014;(1):71–75. (In Russ).]</mixed-citation><mixed-citation xml:lang="en">Геппе Н.А., Снегоцкая М.Н., Пенкина М.В. Алгоритм лечения кашля у детей // Фарматека. — 2014. — № 1 — С. 71–75. [Geppe NA, Snegotskaya MN, Penkina MV. Algoritm lecheniya kashlya u detei. Farmateka. 2014;(1):71–75. (In Russ).]</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Riise GC, Qvarfordt I, Larsson S, et al. Inhibitory effect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitro. Respiration. 2000;67(5):552–558. doi: 10.1159/000067473.</mixed-citation><mixed-citation xml:lang="en">Riise GC, Qvarfordt I, Larsson S, et al. Inhibitory effect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitro. Respiration. 2000;67(5):552–558. doi: 10.1159/000067473.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Schwandt LQ, Van Weissenbruch R, Stokroos I, et al. Prevention of biofilm formation by dairy products and N-acetylcysteine on voice prostheses in an artificial throat. Acta Otolaryngol. 2004; 124(6):726–731. doi: 10.1080/00016480410022516.</mixed-citation><mixed-citation xml:lang="en">Schwandt LQ, Van Weissenbruch R, Stokroos I, et al. Prevention of biofilm formation by dairy products and N-acetylcysteine on voice prostheses in an artificial throat. Acta Otolaryngol. 2004; 124(6):726–731. doi: 10.1080/00016480410022516.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao T, Liu Y. N-acetylcysteine inhibit biofilms produced by Pseudomonas aeruginosa. BMC Microbiol. 2010;10:140. doi: 10.1186/1471-2180-10-140.</mixed-citation><mixed-citation xml:lang="en">Zhao T, Liu Y. N-acetylcysteine inhibit biofilms produced by Pseudomonas aeruginosa. BMC Microbiol. 2010;10:140. doi: 10.1186/1471-2180-10-140.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Pintucci JP, Corno S, Garotta M. Biofilms and infections of the upper respiratory tract. Eur Rev Med Pharmacol Sci. 2010;14(8):683–690.</mixed-citation><mixed-citation xml:lang="en">Pintucci JP, Corno S, Garotta M. Biofilms and infections of the upper respiratory tract. Eur Rev Med Pharmacol Sci. 2010;14(8):683–690.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Marchese A, Bozzolasco M, Gualco L, et al. Effect of fosfomycin alone and in combination with N-acetylcysteine on E. coli biofilms. Int J Antimicrob Agents. 2003;22 Suppl 2:95–100. doi: 10.1016/S0924-8579(03)00232-2.</mixed-citation><mixed-citation xml:lang="en">Marchese A, Bozzolasco M, Gualco L, et al. Effect of fosfomycin alone and in combination with N-acetylcysteine on E. coli biofilms. Int J Antimicrob Agents. 2003;22 Suppl 2:95–100. doi: 10.1016/S0924-8579(03)00232-2.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">El-Feky MA, El-Rehewy MS, Hassan MA, et al. Effect of ciprofloxacin and N- acetylcysteine on bacterial adherence and biofilm formation on ureteral stent surfaces. Pol J Microbiol. 2009;58(3):261–267.</mixed-citation><mixed-citation xml:lang="en">El-Feky MA, El-Rehewy MS, Hassan MA, et al. Effect of ciprofloxacin and N- acetylcysteine on bacterial adherence and biofilm formation on ureteral stent surfaces. Pol J Microbiol. 2009;58(3):261–267.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Macchi A, Ardito F, Marchese A, et al. Efficacy of N-acetylcisteine in combination with thiamphenicol in sequential (intramuscular/aerosol) therapy of upper respiratory tract infections even if sustained by bacterial biofilms. J Chemother. 2006;18(5):507–513. doi: 10.1179/joc.2006.18.5.507.</mixed-citation><mixed-citation xml:lang="en">Macchi A, Ardito F, Marchese A, et al. Efficacy of N-acetylcisteine in combination with thiamphenicol in sequential (intramuscular/aerosol) therapy of upper respiratory tract infections even if sustained by bacterial biofilms. J Chemother. 2006;18(5):507–513. doi: 10.1179/joc.2006.18.5.507.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Leite B, Gomes F, Teixeira P, et al. Staphylococcus epidermidis biofilms control by N- acetylcysteine and rifampicin. Am J Ther. 2013;20(4):322–328. doi: 10.1097/MJT.0b013e318209e17b.</mixed-citation><mixed-citation xml:lang="en">Leite B, Gomes F, Teixeira P, et al. Staphylococcus epidermidis biofilms control by N- acetylcysteine and rifampicin. Am J Ther. 2013;20(4):322–328. doi: 10.1097/MJT.0b013e318209e17b.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Leite B, Gomes F, Teixeira P, et al. Combined effect of linezolid and N-acetylcysteine against Staphylococcus epidermidis biofilms. Enferm Infecc Microbiol Clin. 2013;31(10):655–659. doi: 10.1016/j.eimc.2012.11.011.</mixed-citation><mixed-citation xml:lang="en">Leite B, Gomes F, Teixeira P, et al. Combined effect of linezolid and N-acetylcysteine against Staphylococcus epidermidis biofilms. Enferm Infecc Microbiol Clin. 2013;31(10):655–659. doi: 10.1016/j.eimc.2012.11.011.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Choe WT, Murray MT, Stidham KR, Roberson JB. N-Acetylcysteine as an adjunct for refractory ear infections. Otol Neurotol. 2007;28(8):1022–1025. doi: 10.1097/MAO.0b013e318155a4d3.</mixed-citation><mixed-citation xml:lang="en">Choe WT, Murray MT, Stidham KR, Roberson JB. N-Acetylcysteine as an adjunct for refractory ear infections. Otol Neurotol. 2007;28(8):1022–1025. doi: 10.1097/MAO.0b013e318155a4d3.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Chalumeau M, Duijvestijn YCM. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease. Cochrane Database Syst Rev. 2013(5):CD003124. doi: 10.1002/14651858.CD003124.pub4.</mixed-citation><mixed-citation xml:lang="en">Chalumeau M, Duijvestijn YCM. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease. Cochrane Database Syst Rev. 2013(5):CD003124. doi: 10.1002/14651858.CD003124.pub4.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Baiardi P, Ceci A, Felisi M, et al. In-label and off-label use of respiratory drugs in the Italian paediatric population. Acta Paediatr. 2010;99(4):544–549. doi: 10.1111/j.1651- 2227.2009.01668.x.</mixed-citation><mixed-citation xml:lang="en">Baiardi P, Ceci A, Felisi M, et al. In-label and off-label use of respiratory drugs in the Italian paediatric population. Acta Paediatr. 2010;99(4):544–549. doi: 10.1111/j.1651- 2227.2009.01668.x.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Zuidgeest MG, van Dijk L, Smit HA, et al. Prescription of respiratory medication without an asthma diagnosis in children: a population based study. BMC Health Serv Res. 2008;8:16. doi: 10.1186/1472-6963-8-16.</mixed-citation><mixed-citation xml:lang="en">Zuidgeest MG, van Dijk L, Smit HA, et al. Prescription of respiratory medication without an asthma diagnosis in children: a population based study. BMC Health Serv Res. 2008;8:16. doi: 10.1186/1472-6963-8-16.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Bianchi M, Clavenna A, Sequi M, et al. Spirometry testing in a popu lation of Italian children: age and gender differences. Respir Med. 2012;106(10):1383–1388. doi: 10.1016/j.rmed.2012.06.005.</mixed-citation><mixed-citation xml:lang="en">Bianchi M, Clavenna A, Sequi M, et al. Spirometry testing in a popu lation of Italian children: age and gender differences. Respir Med. 2012;106(10):1383–1388. doi: 10.1016/j.rmed.2012.06.005.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Conroy S. Association between licence status and medication errors. Arch Dis Child. 2011;96(3):305–306. doi: 10.1136/adc.2010.191940.</mixed-citation><mixed-citation xml:lang="en">Conroy S. Association between licence status and medication errors. Arch Dis Child. 2011;96(3):305–306. doi: 10.1136/adc.2010.191940.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
