vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v15i6.1658vsp-1699Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWПрофилактика аллергии: от иммунологии беременности до вскармливания детей первых месяцев жизниPrevention of Allergy: From Immunology of Pregnancy To Infant Feeding in the First Months of Lifehttps://orcid.org/0000-0001-6540-9630УкраинцевС. Е.UkraintsevSergey E.

медицинский директор ООО «Нестле Россия» Адрес: 115054, Москва, Павелецкая площадь, д. 2, стр. 1, тел.: +7 (495) 725-70-00

Moscow, Russian Federation

sergey.ukraintsev@ru.nestle.comМедицинский директор ООО «Нестле Россия»РоссияMedical Director of Nestle Russia LLCRussian Federation201629122016156604609Copyright © Украинцев С.Е., 20162016Украинцев С.Е.Ukraintsev S.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1699

Обоснованный интерес аллергологов вызывает продолжающееся увеличение числа случаев аллергических болезней в детской популяции. В статье рассмотрены основные механизмы формирования иммунологического ответа в свете модуляции риска развития аллергии у ребенка. Обсуждается новый подход к назначению гипоаллергенных диет здоровым беременным и кормящим женщинам с точки зрения профилактики аллергии у ребенка. Отдельный раздел посвящен влиянию режима вскармливания ребенка в первые месяцы жизни на риск формирования аллергии в старшем возрасте, а также ключевые механизмы формирования феномена оральной толерантности. Результаты исследований иммунологических процессов, лежащих в основе феномена оральной толерантности, подтверждают возможность снижения риска формирования аллергии к белкам коровьего молока у детей, находящихся на искусственном вскармливании, с помощью смесей на основе гидролизованного белка.

The continued increase in the incidence of allergic diseases in children population generates reasonable interest of allergists. The article describes the basic mechanisms of immunological response in light of the allergy risk modulation in children. It discusses a new approach to the prescription of hypoallergenic diets for healthy pregnant and lactating women to prevent allergies in children. A separate section examines the influence of the infant feeding mode in the first months of life on the risk of formation of allergies as a child grows, as well as key mechanisms for the formation of the oral tolerance phenomenon. The results from the study of immunological processes that underlie the phenomenon of oral tolerance confirm the ability to reduce the risk of formation of cow's milk protein allergy in formula-fed infants by using formulas based on hydrolysed protein.

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The authors declare that there are no conflicts of interest present.