<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/vsp.v13i4.1088</article-id><article-id custom-type="elpub" pub-id-type="custom">vsp-171</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБМЕН ОПЫТОМ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXCHANGE OF EXPERIENCE</subject></subj-group></article-categories><title-group><article-title>НОВЫЕ ЛЕКАРСТВЕННЫЕ ФОРМЫ ГИДРОКОРТИЗОНА 17-БУТИРАТА В АРСЕНАЛЕ СРЕДСТВ ДЛЯ НАРУЖНОЙ ТЕРАПИИ АТОПИЧЕСКОГО ДЕРМАТИТА У ДЕТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>NEW FORMULATIONS OF HYDROCORTISONE-17-BUTYRATE IN THE ARSENAL OF MEANS FOR TOPICAL TREATMENT OF ATOPIC DERMATITIS IN CHILDREN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Короткий</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Korotkii</surname><given-names>N. G.</given-names></name></name-alternatives><email xlink:type="simple">kng40@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гамаюнов</surname><given-names>Б. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Gamayunov</surname><given-names>B. N.</given-names></name></name-alternatives><bio xml:lang="en"><p>Korotkii Nikolai Gavrilovich, PhD, professor, Head of Dermatovenereological Department of Pediatric Faculty</p></bio><email xlink:type="simple">kng40@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University, Moscow<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Российская детская клиническая больница, Москва<country>Россия</country></aff><aff xml:lang="en">Russian Child Clinical Hospital, Moscow<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>02</day><month>08</month><year>2014</year></pub-date><volume>13</volume><issue>4</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>74</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Короткий Н.Г., Гамаюнов Б.Н., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Короткий Н.Г., Гамаюнов Б.Н.</copyright-holder><copyright-holder xml:lang="en">Korotkii N.G., Gamayunov B.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/171">https://vsp.spr-journal.ru/jour/article/view/171</self-uri><abstract><p>Наружная терапия атопического дерматита у детей остается сложной и многофакторной проблемой. Нерациональный выбор средств лечения может повлечь ухудшение состояния ребенка, вызывать осложнения дерматоза, способствовать развитию «атопического марша». «Золотым стандартом» наружной терапии атопического дерматита остаются топические глюкокортикоиды. Их применение не ограничивается традиционными лекарственными формами, такими как крем и мазь. Представлены особенности новых лекарственных форм (эмульсии с разным содержанием липидов), сформулированы рекомендации по их практическому использованию, описан клинический опыт их использования при лечении детей с атопическим дерматитом.</p></abstract><trans-abstract xml:lang="en"><p>Topical therapy of atopic dermatitis in children is a complex and multifactorial problem. Irrational choice of means of treatment may lead to the deterioration of the child, cause complications of dermatosis, promote the development of «atopic march». Topical treatment’s «Gold standard» is topical corticosteroids. The application of these medicines is not limited to conventional dosage forms such as cream and ointment. The features of the new formulations are presented (emulsions with different lipid concentration), the recommendations on their practical use are stated, the clinical experience of their application in the treatment of children with atopic dermatitis is described.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>атопический дерматит</kwd><kwd>лечение</kwd><kwd>топические глюкокортикоиды</kwd><kwd>гидрокортизона 17-бутират</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>atopic dermatitis</kwd><kwd>treatment</kwd><kwd>topical corticosteroids</kwd><kwd>hydrocortisone-17-butyrate</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Компания «Астеллас»</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>“Astellas”</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Handbook of Atopic Eczema. 2nd edn. Ring J.B. Przybilla, T. Ruzicka (eds.). Heidelberg: Springer. 2006.</mixed-citation><mixed-citation xml:lang="en">Handbook of Atopic Eczema. 2nd edn. Ring J.B. Przybilla, T. Ruzicka (eds.). Heidelberg: Springer. 2006.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ring J. Allergy in Practice. Heidelberg: Springer. 2004. 635 p.</mixed-citation><mixed-citation xml:lang="en">Ring J. Allergy in Practice. Heidelberg: Springer. 2004. 635 p.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Johansson S.G., Bieber T., Dahl R., Friedmann P.S., Lanier B.Q., Lockey R.F. et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J. Allergy Clin. Immunol. 2004; 113: 832–836.</mixed-citation><mixed-citation xml:lang="en">Johansson S.G., Bieber T., Dahl R., Friedmann P.S., Lanier B.Q., Lockey R.F. et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J. Allergy Clin. Immunol. 2004; 113: 832–836.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Khaitov R. M., Kubanova A. A. Consilium medicum — Consilium medicum. 2004; 3: 167–173.</mixed-citation><mixed-citation xml:lang="en">Khaitov R. M., Kubanova A. A. Consilium medicum — Consilium medicum. 2004; 3: 167–173.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Carrol C.L., Balkrishnan R., Feldman S.R., Fleisher A.B., Jr, Manuel J.C. The burden of atopic dermatitis: impact on the patient, family and society. Pediatr. Dermatol. 2005; 22: 192–199.</mixed-citation><mixed-citation xml:lang="en">Carrol C.L., Balkrishnan R., Feldman S.R., Fleisher A.B., Jr, Manuel J.C. The burden of atopic dermatitis: impact on the patient, family and society. Pediatr. Dermatol. 2005; 22: 192–199.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Turner J.D., Schwartz R.A. Atopic dermatitis. A clinical challenge. Acta Dermatovenerol. Alp. Panonica Adriat. 2006; 15 (2): 59–68.</mixed-citation><mixed-citation xml:lang="en">Turner J.D., Schwartz R.A. Atopic dermatitis. A clinical challenge. Acta Dermatovenerol. Alp. Panonica Adriat. 2006; 15 (2): 59–68.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ong P.Y., Leung D.Y. Immune dysregulation in atopic dermatitis. Curr. Allergy Asthma Rep. 2006; 6 (5): 384–389.</mixed-citation><mixed-citation xml:lang="en">Ong P.Y., Leung D.Y. Immune dysregulation in atopic dermatitis. Curr. Allergy Asthma Rep. 2006; 6 (5): 384–389.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Leung D.Y. Our evolving understanding of the functional role of filaggrin in atopic dermatitis. J. Allergy Clin. Immunol. 2009; 124 (3): 494–495.</mixed-citation><mixed-citation xml:lang="en">Leung D.Y. Our evolving understanding of the functional role of filaggrin in atopic dermatitis. J. Allergy Clin. Immunol. 2009; 124 (3): 494–495.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Korotkii N. G., Tikhomirov A. A., Gamayunov B. N. Klin. dermatol. i venerol. — Clinical dermatology and venereology. 2013; 4: 51–55.</mixed-citation><mixed-citation xml:lang="en">Korotkii N. G., Tikhomirov A. A., Gamayunov B. N. Klin. dermatol. i venerol. — Clinical dermatology and venereology. 2013; 4: 51–55.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Baumer J.H. Guideline review: atopic eczema in children. Arch. Dis. Child. Edu. Pract. Ed. 2008; 93 (3): 93–97.</mixed-citation><mixed-citation xml:lang="en">Baumer J.H. Guideline review: atopic eczema in children. Arch. Dis. Child. Edu. Pract. Ed. 2008; 93 (3): 93–97.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Korotkii N. G., Tikhomirov A. A., Andreenko O. N., Gamayunov B. N. Opyt primeneniya mazi lokoid v terapii detei s khronicheskimi vospalitel’nymi zabolevaniyami kozhi. Sb. trudov yubileinoi nauch.-prakt. konf. «Aktual’nye voprosy i osobennosti dermatovenerologii v detskom vozraste. Problemy i perspektivy» [Experience in the Application of the Ointment Lokoid in Therapy of Children with Chronic Inflammatory Diseases of the Skin. Proceedings of the Anniversary Scientific-Practical. Conf. “Actual Issues and Features of Dermatovenereology in Childhood. Problems and Prospects”]. Moscow, Meditsinskaya kniga, 2007. pp. 91–94.</mixed-citation><mixed-citation xml:lang="en">Korotkii N. G., Tikhomirov A. A., Andreenko O. N., Gamayunov B. N. Opyt primeneniya mazi lokoid v terapii detei s khronicheskimi vospalitel’nymi zabolevaniyami kozhi. Sb. trudov yubileinoi nauch.-prakt. konf. «Aktual’nye voprosy i osobennosti dermatovenerologii v detskom vozraste. Problemy i perspektivy» [Experience in the Application of the Ointment Lokoid in Therapy of Children with Chronic Inflammatory Diseases of the Skin. Proceedings of the Anniversary Scientific-Practical. Conf. “Actual Issues and Features of Dermatovenereology in Childhood. Problems and Prospects”]. Moscow, Meditsinskaya kniga, 2007. pp. 91–94.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Schafer-Korting M., Kleuser B., Ahmed M., Holtje H.D., Korting H.C. Glucocorticoids for human skin: new aspects of the mechanism of action. Skin Pharmacol. Physiol. 2005; 18: 103–114.</mixed-citation><mixed-citation xml:lang="en">Schafer-Korting M., Kleuser B., Ahmed M., Holtje H.D., Korting H.C. Glucocorticoids for human skin: new aspects of the mechanism of action. Skin Pharmacol. Physiol. 2005; 18: 103–114.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Brazzini B., Pimpinelli N. New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. Am. J. Clin. Dermatol. 2002; 3 (1): 47–58.</mixed-citation><mixed-citation xml:lang="en">Brazzini B., Pimpinelli N. New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. Am. J. Clin. Dermatol. 2002; 3 (1): 47–58.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tadicherla S., Ross K, Shenefelt P.D., Fenske N.A. Topical corticosteroids in dermatology. J. Drugs Dermatol. 2009; 8 (12): 1093–1105.</mixed-citation><mixed-citation xml:lang="en">Tadicherla S., Ross K, Shenefelt P.D., Fenske N.A. Topical corticosteroids in dermatology. J. Drugs Dermatol. 2009; 8 (12): 1093–1105.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pierard GE. Hydrocortisone 17-butyrate (Locoid). A thirtyyear ongoing innovative drug. Rev. Med. Liege. 2006; 61 (2): 128–130.</mixed-citation><mixed-citation xml:lang="en">Pierard GE. Hydrocortisone 17-butyrate (Locoid). A thirtyyear ongoing innovative drug. Rev. Med. Liege. 2006; 61 (2): 128–130.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Wieriks J., Hespe W., Jaitly K.D., van Kan B.L. Topical and systemic effects of hydrocortisone 17-butyrate. Dermatologica. 1976; 152 (Suppl. 1): 181–195.</mixed-citation><mixed-citation xml:lang="en">Wieriks J., Hespe W., Jaitly K.D., van Kan B.L. Topical and systemic effects of hydrocortisone 17-butyrate. Dermatologica. 1976; 152 (Suppl. 1): 181–195.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kochergin N. G., Petrunin D. D. Klin. dermatol. i venerol. — Clinical dermatology and venereology. 2011; 6: 84–94.</mixed-citation><mixed-citation xml:lang="en">Kochergin N. G., Petrunin D. D. Klin. dermatol. i venerol. — Clinical dermatology and venereology. 2011; 6: 84–94.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
