vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v16i3.1731vsp-1757Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL ARTICLESКОМПОНЕНТЫ МЕТАБОЛИЧЕСКОГО СИНДРОМА У ДЕТЕЙ И ПОДРОСТКОВ С РАЗЛИЧНЫМ УРОВНЕМ ВИТАМИНА D: РЕЗУЛЬТАТЫ ОДНОМОМЕНТНОГО ИССЛЕДОВАНИЯCOMPONENTS OF THE METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH DIFFERENT LEVELS OF VITAMIN D: A CROSS-SECTIONAL STUDYhttps://orcid.org/0000-0003-2521-0824МалявскаяС. И.MalyavskayaSvetlana I.

Архангельск

Arkhangelsk

https://orcid.org/0000-0003-1865-6748ЛебедевА. В.LebedevАndrej V.

Лебедев Андрей Викторович - кандидат медицинских наук, доцент кафедры патологической физиологии СГМУ.

163000, Архангельск, Троицкий пр-т, д. 51, тел.: +7 (8182) 21-12-52

Arkhangelsk

andruleb@yandex.ruhttps://orcid.org/0000-0002-3132-6439КостроваГ. Н.KostrovaGalina N.

Архангельск

Arkhangelsk

Северный государственный медицинский университетРоссияNorthern State Medical UniversityRussian Federation201715072017163213219Copyright © Малявская С.И., Лебедев А.В., Кострова Г.Н., 20172017Малявская С.И., Лебедев А.В., Кострова Г.Н.Malyavskaya S.I., Lebedev А.V., Kostrova G.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1757

Витамин D является значимым фактором риска атерогенных нарушений. Представляет интерес изучение взаимосвязи дефицита витамина D с компонентами метаболического синдрома, инсулинорезистентностью  и маркерами хронического воспаления в разных возрастных группах.

Цель  исследования

Цель  исследования: изучить сопряженность  компонентов метаболического синдрома и проатерогенных метаболических нарушений с уровнем обеспеченности витамином D у детей и подростков.

Методы

Методы. В поперечном (одномоментном) исследовании определяли уровень 25(ОН)D в сыворотке крови у детей и подростков. Связь уровня 25(ОН)D с наличием признаков метаболического синдрома оценивалась в квартильных группах.

Результаты

Результаты. В исследование включены 319 детей и подростков (из них 49% — девочки) в возрасте 10–15 лет. В I квартиле по уровню 25(ОН)D отмечались более высокие по сравнению с IV квартилем средние значения содержания инсулина (11,5 ± 6,3 и 7,3 ± 4,0 ммоль/л; р < 0,001), индекса HOMA (2,4 ± 0,8 и 1,6 ± 0,7; р < 0,001), индекса массы тела (22,6 ± 4,3 и 19,3 ± 3,9 кг/м2; р = 0,012), окружности талии (68 ± 11 и 61 ± 12 см; р = 0,034), концентрации в крови C-реактивного  белка (2,3 ± 1 и 0,9 ± 0,7 мг/мл; р < 0,001), диастолического  артериального давления (70 ± 7 и 65 ± 6 мм рт. ст.; р = 0,028), мочевой кислоты (0,29 ± 0,06 и 0,21 ± 0,06 ммоль/л; р = 0,021), глюкозы (4,8 ± 0,6 и 4,6 ± 0,6 ммоль/л; р = 0,011), триглицеридов (0,86 ± 0,37 и 0,72 ± 0,31 ммоль/л; р = 0,017) и более низкие средние значения уровня холестерина липопротеидов высокой плотности (1,38 ± 0,36 и 1,58 ± 0,31 ммоль/л; р  =  0,011).  Многофакторный  регрессионный  анализ  показал   независимую  связь  уровня  25(ОН)D  с  уровнем C-реактивного белка (β = -0,55; p < 0,001) и показателем индекса HOMA (β = -0,96; p < 0,001).

Background

Background. Vitamin D is a significant risk factor for atherogenic disorders. It is of interest to study the relationship between vitamin D deficiency and the components of the metabolic syndrome, insulin resistance and markers of chronic inflammation in different age groups.

Objective

Objective.  Our aim was to study association of the components  of the metabolic syndrome and pro-atherogenic  metabolic disorders with vitamin D levels in children and adolescents.

Methods

Methods. In a cross-sectional (one-stage) study, the serum 25(OH)D level in children and adolescents was determined. The relationship between the 25(ОН)D level and the presence of the metabolic syndrome was assessed in quartile groups.

Results

Results. The study included 319 children and adolescents (49% — girls) aged 10–15 years. In the quartile I in terms of the 25(ОН)D level, higher (as compared with the quartile IV) mean level values of insulin (11.5 ± 6.3 and 7.3 ± 4.0 mmol/L, p <0.001), HOMA index (2.4 ± 0.8 and 1.6 ± 0.7, p <0.001), body mass index (22.6 ± 4.3 and 19.3 ± 3.9 kg/m2, p = 0.012), waist circumference (68 ± 11 and 61 ± 12 cm, p = 0.034), blood concentration of C-reactive protein (2.3 ± 1 and 0.9 ± 0.7 mg/ml, p <0.001), diastolic blood pressure (70 ± 7 and 65 ± 6 mm Hg, р = 0.028), uric acid (0.29 ± 0.06 and 0.21 ± 0.06 mmol/L, р = 0.021), glucose (4.8 ± 0.6 and 4.6 ± 0.6 mmol/L, p = 0.011), triglycerides (0.86 ± 0.37 and 0.72 ± 0.31 mmol/L, р = 0.017), and lower mean level values of highdensity lipoprotein cholesterol (1.38 ± 0.36 and 1.58 ± 0.31 mmol/L, p = 0.011) were noted. Multivariate regression analysis showed an independent  relationship between the 25(ОН)D level, C-reactive  protein level (β = -0.55,  p <0.001),  and HOMA index (β = -0.96, p < 0.001).

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The authors declare that there are no conflicts of interest present.