References

vsp

Вопросы современной педиатрии

Current Pediatrics

1682-55271682-5535

Издательство «ПедиатрЪ»

10.15690/vsp.v16i6.1820

vsp-1834

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

LITERATURE REVIEW

Поражение почек и перинатальное программирование артериальной гипертензии: результаты экспериментальных исследований

Kidney Disease and Perinatal Programming of Arterial Hypertension: the Results of Experimental Researches

Ковтун

О. П.

Kovtun

Olga P.

Цывьян

П. Б.

Tsyvian

Pavel B.

доктор медицинских наук, профессор, заведующий кафедрой нормальной физиологии УГМУ, ведущий научный сотрудник Уральского НИИ охраны материнства и младенчества

Адрес: 620028, Екатеринбург, ул. Репина д. 3, тел.: +7 (343) 214-86-79

pavel.tsyvian@gmail.com

Уральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation

Уральский государственный медицинский университет Уральский НИИ охраны материнства и младенчестваРоссияUral State Medical University Ural Research Institute for Maternal and Infant Childhood ProtectionRussian Federation

2017

23012018

166481486

2018

Ковтун О.П., Цывьян П.Б.

Kovtun O.P., Tsyvian P.B.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://vsp.spr-journal.ru/jour/article/view/1834

Ухудшение условий развития в перинатальный период (голодание матери, избыток ионов натрия в ее рационе, воздействие глюкокортикостероидов, плацентарная недостаточность) программирует значительные изменения экскреции ионов натрия у новорожденного и ведет к развитию артериальной гипертензии. Исследования на экспериментальных животных показывают, что неблагоприятные условия внутриутробного развития могут уменьшить эффективную площадь гломерулярной фильтрации и ее скорость. Эти обстоятельства увеличивают экспрессию мембранных переносчиков ионов натрия в апикальных мембранах, продукцию супероксидных радикалов и усиливают реабсорбцию натрия. В статье обсуждаются потенциальные механизмы перинатального программирования почечной гипертензии у человека.

Deterioration of development conditions in the perinatal period (starvation of the mother, excess sodium ions in her diet, exposure to glucocorticosteroids, placental insufficiency) programs significant changes in the excretion of sodium ions in the newborn and leads to the development of hypertension. Studies on experimental animals show that unfavourable conditions of intrauterine development can reduce the effective area of glomerular filtration and its rate. These circumstances increase the expression of membrane carriers of sodium ions in the apical membranes, the production of superoxide radicals and enhance the reabsorption of sodium. The article discusses the potential mechanisms of perinatal programming of renal hypertension in humans.

детиперинатальный периодперинатальное программированиеартериальная гипертензияпочкиоксидативный стресс

childrenperinatal periodperinatal programminghypertensionkidneysoxidative stress

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The authors declare that there are no conflicts of interest present.