vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v16i6.1821vsp-1835Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWКишечная микробиота: формирование в раннем возрасте, влияние на здоровье, способы коррекцииIntestinal Microbiota: Early Formation, Health Effects, and Correction Wayshttps://orcid.org/0000-0002-7442-9278ЯкушинА. С.YakushinAndrey S.

врач-терапевт ООО «Центр семейной медицины»

Адрес: 630090, Новосибирск, ул. Правды, д. 8

yakushin_as@cnmt.ruhttps://orcid.org/0000-0001-6540-9630УкраинцевС. Е.UkraintsevSergey E.https://orcid.org/0000-0003-1173-7553ДенисовМ. Ю.DenisovMikhail Yu.ООО «Центр семейной медицины»РоссияCenter for Family Medicine LLCRussian FederationНациональный медицинский исследовательский центр здоровья детей OOO «Нестле Россия»РоссияNational Medical Research Center for Children’s Health, Moscow, Russian Federation Nestle Russia LLCRussian FederationИнститут медицины и психологии Новосибирского национального исследовательского государственного университетаРоссияInstitute of Medicine and PsychologyRussian Federation201723012018166487492Copyright © Якушин А.С., Украинцев С.Е., Денисов М.Ю., 20182018Якушин А.С., Украинцев С.Е., Денисов М.Ю.Yakushin A.S., Ukraintsev S.E., Denisov M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1835

Увеличение распространенности случаев заболеваний, возникающих в результате нарушений метаболизма и функций иммунной системы, во многом связано с  патологическими отклонениями в составе кишечной микробиоты в раннем возрасте. В  обзоре рассматриваются этапы и условия естественного развития кишечной микробиоты,  начиная с внутриутробного  периода. Проведен анализ возможных факторов риска нарушений состава кишечной  микробиоты в пре- и постнатальный периоды. Приведены результаты современных  исследований об ассоциации между составом кишечной микробиоты в младенческом возрасте и развитием «болезней цивилизации» — в более старшем. Отдельный раздел посвящен  обсуждению результативности и целесообразности приема пробиотических препаратов с целью профилактики заболеваний.

An increase in the prevalence of diseases resulting from disorders of metabolism and immune system functions is largely due to disturbances in the intestinal microbiota composition at an early age. The review  considers the stages and conditions of the natural development of the  intestinal microbiota, starting from the intrauterine period. We  conducted the analysis of possible risk factors for the intestinal  microbiota composition disorders in the pre- and postnatal periods. The  results of modern studies on the association between the intestinal  microbiota composition in infancy and the development of «civilization  diseases» at older ages are given. A separate section is devoted to a  discussion of the efficacy and appropriateness of taking probiotic drugs for disease prevention.

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The authors declare that there are no conflicts of interest present.