vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v17i1.1855vsp-1865Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWКЛИНИКО-ФАРМАКОЛОГИЧЕСКИЕ ПОДХОДЫ К ОПТИМИЗАЦИИ РЕЖИМА ДОЗИРОВАНИЯ АНТИБАКТЕРИАЛЬНЫХ ПРЕПАРАТОВ В ПЕДИАТРИИCLINICAL AND PHARMACOLOGICAL APPROACHES TO OPTIMIZE THE DOSING REGIMEN OF ANTIBACTERIAL DRUGS IN PEDIATRICShttps://orcid.org/0000-0001-6528-1585ЛазареваН. Б.LazarevaNatal’ya B.

Лазарева Наталья Борисовна - доктор медицинских наук, профессор кафедры клинической фармакологии и пропедевтики внутренних болезней.

119991, Москва, ул. Большая Пироговская, д. 2, стр. 4

natalia.lazareva@gmail.comhttps://orcid.org/0000-0001-6589-7654ШихЕ. В.ChikhEvgeniya V.https://orcid.org/0000-0002-0535-2916ДроздовВ. Н.DrozdovVladimir N.https://orcid.org/0000-0002-4374-9754РеброваЕ. В.RebrovaEkaterina V.Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical UniversityRussian Federation2018010420181715460Copyright © Лазарева Н.Б., Ших Е.В., Дроздов В.Н., Реброва Е.В., 20182018Лазарева Н.Б., Ших Е.В., Дроздов В.Н., Реброва Е.В.Lazareva N.B., Chikh E.V., Drozdov V.N., Rebrova E.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1865

Рациональное использование антибактериальных препаратов у детей подразумевает адекватный выбор необходимого лекарственного средства, режима его дозирования и продолжительности лечения с целью достижения максимальной эффективности и минимизации токсических эффектов. Критическое значение для оптимизации режима дозирования имеет знание фармакокинетического и фармакодинамического профиля антибактериального препарата. Стратегия индивидуального выбора режима дозирования с учетом принципов фармакокинетики и фармакодинамики может быть особенно эффективна у пациентов с ожидаемо измененными параметрами фармакокинетики и при инфекциях, вызванных штаммами бактерий с низкой чувствительностью к антибиотикам. В обзоре изложены современные представления о показателях фармакокинетического и фармакодинамического профиля антибактериальных препаратов, наиболее часто используемых в педиатрии, и их связи с клинической эффективностью проводимой терапии.

The rational use of antibacterial drugs in children implies an adequate choice of the necessary medication, its dosing regimen, and the duration of treatment in order to achieve maximum efficacy and minimize toxic effects. The knowledge of pharmacokinetic and pharmacodynamic profiles of the antibacterial drug plays a crucial role for optimizing the dosing regimen. The strategy of individual choice of the dosing regimen, taking into account the principles of pharmacokinetics and pharmacodynamics, can be especially effective in patients with the expectedly changed parameters of pharmacokinetics and in infections caused by bacteria strains with low sensitivity to antibiotics. The review presents a contemporary view of pharmacokinetic and pharmacodynamic profiles of antibacterial drugs most commonly used in pediatrics and their relationship to the clinical efficacy of the administered therapy.

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The authors declare that there are no conflicts of interest present.