vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v17i1.1859vsp-1869Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCEРОЛЬ НАРУШЕНИЙ ЭПИДЕРМАЛЬНОГО БАРЬЕРА ПРИ АТОПИЧЕСКОМ ДЕРМАТИТЕ: СОВРЕМЕННЫЕ КОНЦЕПЦИИ ПАТОГЕНЕЗА ЗАБОЛЕВАНИЯTHE ROLE OF EPIDERMAL BARRIER IMPAIRMENTS IN ATOPIC DERMATITIS: MODERN CONCEPTS OF DISEASE PATHOGENESIShttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinNikolay N.

Мурашкин Николай Николаевич - доктор медицинских наук, заведующий отделением дерматологии НМИЦ здоровья детей; профессор кафедры дерматовенерологии и косметологии ЦГМА; профессор кафедры педиатрии и детской ревматологии Первого МГМУ им. И.М. Сеченова.

119991, Москва, Ломоносовский пр-т, д. 2, стр. 1,  тел.: +7 (499) 134-08-89

Moscow

m_nn2001@mail.ruhttps://orcid.org/0000-0002-8232-8936АмбарчянЭ. Т.AmbarchianEduard T.

Москва

Moscow

https://orcid.org/0000-0002-6034-8231МатерикинА. И.MaterikinAlexander I.

Москва

Moscow

https://orcid.org/0000-0002-4107-4642ЕпишевР. В.EpishevRoman V.

Москва

Moscow

Национальный медицинский исследовательский центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)РоссияNational Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University (Sechenov University)Russian FederationНациональный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian Federation2018020420181718588Copyright © Мурашкин Н.Н., Амбарчян Э.Т., Материкин А.И., Епишев Р.В., 20182018Мурашкин Н.Н., Амбарчян Э.Т., Материкин А.И., Епишев Р.В.Murashkin N.N., Ambarchian E.T., Materikin A.I., Epishev R.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1869

Атопический дерматит является распространенным хроническим воспалительным заболеванием кожи, характеризуется рецидивирующим течением и прогрессирующим снижением качества жизни. Последние исследования в этой области демонстрируют многогранность патогенеза атопического дерматита. Взаимодействие таких факторов, как эпидермальная дисфункция, нарушения иммунной системы и последствия генетических мутаций, способствует не только развитию болезни, но и ее прогрессированию и хроническому течению. В статье представлены различные звенья этиопатогенеза атопического дерматита, описана роль липидов, благодаря чему перед специалистами открываются новые «мишени» для терапевтического воздействия.

Atopic dermatitis is a common chronic inflammatory skin disease characterized by a recurring course and progressive decrease in the quality of life. Recent studies in this area demonstrate the multifaceted pathogenesis of atopic dermatitis. Interaction of such factors as epidermal dysfunction, immune system disorders, and the consequences of genetic mutations contributes not only to the development of the disease but also to its progression and chronic course. The article presents various components of the etiopathogenesis of atopic dermatitis, describes the role of lipids, thereby the new therapeutic targets are revealed to specialists.

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The authors declare that there are no conflicts of interest present.