References

vsp

Вопросы современной педиатрии

Current Pediatrics

1682-55271682-5535

Издательство «ПедиатрЪ»

10.15690/vsp.v13i3.1024

vsp-188

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

LITERATURE REVIEW

КИШЕЧНЫЙ МИКРОБИОЦЕНОЗ, ПИЩЕВАЯ ТОЛЕРАНТНОСТЬ И ПИЩЕВАЯ АЛЛЕРГИЯ. СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ

INTESTINAL MICROBIOCENOSIS, FOOD TOLERANCE AND FOOD ALLERGY. CURRENT STATE OF A PROBLEM

Макарова

С. Г.

Makarova

S. G.

Makarova Svetlana Gennadievna, PhD, leading research scientist of the Department of Ill and Healthy Child Nutrition of SCCH, professor of the Department of Allergology and Clinical Immunology of Pediatric Faculty

sm27@yandex.ru

Болдырева

М. Н.

Boldyreva

M. N.

sm27@yandex.ru

Лаврова

Т. Е.

Lavrova

Т. E.

sm27@yandex.ru

Петровская

М. И.

Petrovskaya

М. I.

sm27@yandex.ru

Научный центр здоровья детей, Москва; Первый Московский государственный медицинский университет им. И.М. СеченоваРоссияScientific Centre of Children Health, Moscow; I.M. Sechenov First Moscow State Medical UniversityRussian Federation

«ДНК-Технология»ЗАО НПФ , Москва Институт иммунологии, МоскваРоссия«DNA-Technology» Research and Production Company, CJSC, Moscow; Институт иммунологии, МоскваRussian Federation

НИИ питания, МоскваРоссияScientific Research Institute of Nutrition, MoscowRussian Federation

Научный центр здоровья детей, Москва; Первый Московский государственный медицинский университет им. И.М. СеченоваРоссияScientific Centre of Children Health, Moscow I.M. Sechenov First Moscow State Medical UniversityRussian Federation

2014

19062014

133

Вопросы современной педиатрии

2129

2014

Макарова С.Г., Болдырева М.Н., Лаврова Т.Е., Петровская М.И.

Makarova S.G., Boldyreva M.N., Lavrova Т.E., Petrovskaya М.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://vsp.spr-journal.ru/jour/article/view/188

В обзоре современной литературы подробно рассмотрено влияние бактериального фактора, в первую очередь — индигенной микрофлоры — на формирование пищевой толерантности, а также иммунного ответа ребенка в целом. Формирование микробиоценоза, пищевой и аутогенной толерантности происходит по общим законам. Особое значение в этом процессе имеет первичная колонизация кишечника и становление разнообразия микрофлоры, которое, как показывают результаты последних исследований, заканчивается к 2–4 годам жизни ребенка. В обзоре рассмотрены основные факторы, действующие на формирование кишечной микробиоты у ребенка как антенатально и постнатально, так и на протяжении первых лет жизни, а также их взаимодействие. Подробно обсуждается влияние бактериального фактора на формирование пищевой толерантности и процессы сенсибилизации, а также механизмы этого влияния. Приводятся данные об особенностях состава кишечной микрофлоры у детей с пищевой аллергией, в т.ч. и результаты собственных исследований, посвященных микробиоценозу при пищевой аллергии у детей и разработке тактики ведения детей с даннолй патологией. Рассматриваются основные направления и возможности диетического влияния на состав биоценоза у детей с данной патологией.

In the review of modern literature the influence of a bacterial factor, first of all — indigenous microflora — on formation of food tolerance and immune answer of a child as a whole is in detail considered. Formation of a microbiocenosis, food and autogenic tolerance happens under the general laws. In this process the primary colonization of intestines and formation of a microflora variety which, as results of the last researches show, comes to an end by 2–4 years of life of a child has special value. In the review the major factors influencing the formation of a child intestinal microbiota both antenatal and postnatal and for the first years of life, and also their interaction are considered. The influence of a bacterial factor on formation of food tolerance and sensibilization processes, and also mechanisms of this influence is in detail discussed. The data on features of a structure of intestinal microflora at children with food allergy including the results of own researches devoted to microbiocenosis at children with food allergy and to development of tactics of management of children with this pathology are provided. The main directions and possibilities of dietary influence on biocenosis structure at children with this pathology are considered.

детимикробиоценоз кишечникапищевая толерантностьпищевая аллергияпребиотики

childrenintestinal microbiocenosisfood tolerancefood allergyprebiotics

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The authors declare that there are no conflicts of interest present.