<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/vsp.v17i2.1881</article-id><article-id custom-type="elpub" pub-id-type="custom">vsp-1884</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ  ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>A DOCTOR’S AID</subject></subj-group></article-categories><title-group><article-title>ГРУДНОЕ МОЛОКО, КАКИМ МЫ ЕГО НЕ ЗНАЛИ: ХРОНОБИОЛОГИЯ ГРУДНОГО МОЛОКА</article-title><trans-title-group xml:lang="en"><trans-title>BREAST MILK THAT WE DID NOT KNOW: CHRONOBIOLOGY OF BREAST MILK</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Украинцев</surname><given-names>С. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Ukraintsev</surname><given-names>Sergey E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Украинцев Сергей Евгеньевич - медицинский директор.</p><p>115054, Москва, Павелецкая площадь, д. 2, стр. 1,  тел.: +7 (495) 725-70-00</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">sergey.ukraintsev@ru.nestle.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самаль</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Samal</surname><given-names>Tatyana N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Нестле Россия, ООО</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Nestle Russia LLC</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Белорусский государственный медицинский университет</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>Belarusian State Medical University</institution><country>Belarus</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>22</day><month>05</month><year>2018</year></pub-date><volume>17</volume><issue>2</issue><fpage>148</fpage><lpage>151</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Украинцев С.Е., Самаль Т.Н., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Украинцев С.Е., Самаль Т.Н.</copyright-holder><copyright-holder xml:lang="en">Ukraintsev S.E., Samal T.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/1884">https://vsp.spr-journal.ru/jour/article/view/1884</self-uri><abstract><p>Выполнен анализ современных научных данных об изменениях состава грудного молока в течение срока лактации, оказывающих влияние как на краткосрочные (сон, аппетит), так и долгосрочные (рост и развитие, темперамент, поведение) параметры здоровья ребенка. Представленные сведения будут способствовать лучшему пониманию преимуществ грудного молока и грудного вскармливания для ребенка, а также усилению поддержки и продвижению грудного вскармливания как среди матерей, так и работников здравоохранения.</p></abstract><trans-abstract xml:lang="en"><p>The article analyzes modern scientific data on the changes in breast milk composition during lactation. These changes affect both short-term (sleep, appetite) and long-term parameters (growth and development, temperament, behavior) with respect to the health of the child. This information will help to have a better idea of the benefits of breast milk and breastfeeding for a child and to strengthen a support and promotion of breastfeeding among mothers and health workers.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>грудное молоко</kwd><kwd>хронобиология</kwd><kwd>дети</kwd><kwd>здоровье</kwd></kwd-group><kwd-group xml:lang="en"><kwd>breast milk</kwd><kwd>chronobiology</kwd><kwd>children</kwd><kwd>health</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Нестле Россия, ООО</funding-statement><funding-statement xml:lang="en">Nestle Russia LLC, support</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hanson LA, Korotkova M. The role of breastfeeding in prevention of neonatal infection. Semin Neonatol. 2002;7(4):275–281. doi: 10.1053/siny.2002.0124.</mixed-citation><mixed-citation xml:lang="en">Hanson LA, Korotkova M. The role of breastfeeding in prevention of neonatal infection. Semin Neonatol. 2002;7(4):275–281. doi: 10.1053/siny.2002.0124.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Armstrong J, Reilly JJ, Child Health Information Team. Breastfeeding and lowering the risk of childhood obesity. Lancet. 2002;359(9322):2003–2004. doi: 10.1016/S0140-6736(02)08837-2.</mixed-citation><mixed-citation xml:lang="en">Armstrong J, Reilly JJ, Child Health Information Team. Breastfeeding and lowering the risk of childhood obesity. Lancet. 2002;359(9322):2003–2004. doi: 10.1016/S0140-6736(02)08837-2.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dewey KG. Maternal and fetal stress are associated with impaired lactogenesis in humans. J Nutr. 2001;131(11):3012S–3015S. doi: 10.1093/jn/131.11.3012S.</mixed-citation><mixed-citation xml:lang="en">Dewey KG. Maternal and fetal stress are associated with impaired lactogenesis in humans. J Nutr. 2001;131(11):3012S–3015S. doi: 10.1093/jn/131.11.3012S.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Детское питание. Руководство для врачей / Под ред. В.А. Тутельяна, И.Я. Коня. — М.: МИА; 2017. — С. 224–227.</mixed-citation><mixed-citation xml:lang="en">Detskoe pitanie. Rukovodstvo dlya vrachei. Ed by V.A. Tutel’yan, I.Ya. Kon’. Moscow: MIA; 2017. pp. 224–227. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Karatas Z, Durmus Aydogdu S, Dinleyici EC, et al. Breastmilk ghrelin, leptin, and fat levels changing foremilk to hindmilk: is that important for self-control of feeding? Eur J Pediatr. 2011;170(10): 1273–1280. doi: 10.1007/s00431-011-1438-1.</mixed-citation><mixed-citation xml:lang="en">Karatas Z, Durmus Aydogdu S, Dinleyici EC, et al. Breastmilk ghrelin, leptin, and fat levels changing foremilk to hindmilk: is that important for self-control of feeding? Eur J Pediatr. 2011;170(10): 1273–1280. doi: 10.1007/s00431-011-1438-1.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Li RW, Fein SB, Grummer-Strawn LM. Do infants fed from bottles lack self-regulation of milk intake compared with directly breastfed infants? Pediatrics. 2010;125(6):e1386-e1393. doi: 10.1542/peds.2009-2549.</mixed-citation><mixed-citation xml:lang="en">Li RW, Fein SB, Grummer-Strawn LM. Do infants fed from bottles lack self-regulation of milk intake compared with directly breastfed infants? Pediatrics. 2010;125(6):e1386-e1393. doi: 10.1542/peds.2009-2549.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">DeJeu E. Newborn Not Sleeping? Here Are 6 Reasons Why [Internet]. © 2018 The Baby Sleep Site — Baby Sleep Help [cited 2018 Feb 13]. Available from: http://www.babysleepsite.com/newborns/newborn-not-sleeping-7-reasons/.</mixed-citation><mixed-citation xml:lang="en">DeJeu E. Newborn Not Sleeping? Here Are 6 Reasons Why [Internet]. © 2018 The Baby Sleep Site — Baby Sleep Help [cited 2018 Feb 13]. Available from:  http://www.babysleepsite.com/newborns/newborn-not-sleeping-7-reasons/.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Biran V, Duy AP, Decobert F, et al. Is melatonin ready to be used in preterm infants as a neuroprotectant? Dev Med Child Neurol. 2014;56(8):717–723. doi: 10.1111/dmcn.12415.</mixed-citation><mixed-citation xml:lang="en">Biran V, Duy AP, Decobert F, et al. Is melatonin ready to be used in preterm infants as a neuroprotectant? Dev Med Child Neurol. 2014;56(8):717–723. doi: 10.1111/dmcn.12415.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen Engler A, Hadash A, Shehadeh N, Pillar G. Breastfeeding may improve nocturnal sleep and reduce infantile colic: potential role of breast milk melatonin. Eur J Pediatr. 2012;171(4):729–732. doi: 10.1007/s00431-011-1659-3.</mixed-citation><mixed-citation xml:lang="en">Cohen Engler A, Hadash A, Shehadeh N, Pillar G. Breastfeeding may improve nocturnal sleep and reduce infantile colic: potential role of breast milk melatonin. Eur J Pediatr. 2012;171(4):729–732. doi: 10.1007/s00431-011-1659-3.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cubero J, Valero V, Sanchez J, et al. The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn. Neuro Endocrinol Lett. 2005;26(6):657–661.</mixed-citation><mixed-citation xml:lang="en">Cubero J, Valero V, Sanchez J, et al. The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn. Neuro Endocrinol Lett. 2005;26(6):657–661.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Koletzko B, Brasseur D, Closa R, et al. Protein intake in the first year of life: A risk factor for later obesity? The EU Childhood Obesity project. In: Koletzko B, Dodds PF, Akerblom H, Ashwell M, editors. Early nutrition and its later consequences: new opportunities. Berlin, Germany: Springer-Verlag; 2005. pp. 69–79.</mixed-citation><mixed-citation xml:lang="en">Koletzko B, Brasseur D, Closa R, et al. Protein intake in the first year of life: A risk factor for later obesity? The EU Childhood Obesity project. In: Koletzko B, Dodds PF, Akerblom H, Ashwell M, editors. Early nutrition and its later consequences: new opportunities. Berlin, Germany: Springer-Verlag; 2005. pp. 69–79.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Glynn LM, Davis EP, Schetter CD, et al. Postnatal maternal cortisol levels predict temperament in healthy breastfed infants. Early Hum Dev. 2007;83(10):675–681. doi: 10.1016/j.earlhumdev.2007.01.003.</mixed-citation><mixed-citation xml:lang="en">Glynn LM, Davis EP, Schetter CD, et al. Postnatal maternal cortisol levels predict temperament in healthy breastfed infants. Early Hum Dev. 2007;83(10):675–681. doi: 10.1016/j.earlhumdev.2007.01.003.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hinde K, Skibiel AL, Foster AB, et al. Cortisol in mother’s milk across lactation reflects maternal life history and predicts infant temperament. Behav Ecol. 2015;26(1):269–281. doi: 10.1093/beheco/aru186.</mixed-citation><mixed-citation xml:lang="en">Hinde K, Skibiel AL, Foster AB, et al. Cortisol in mother’s milk across lactation reflects maternal life history and predicts infant temperament. Behav Ecol. 2015;26(1):269–281. doi: 10.1093/beheco/aru186.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Heijtza RD, Wang SG, Anuar F, et al. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A. 2011;108(7):3047–3052. doi: 10.1073/pnas.1010529108.</mixed-citation><mixed-citation xml:lang="en">Heijtza RD, Wang SG, Anuar F, et al. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A. 2011;108(7):3047–3052. doi: 10.1073/pnas.1010529108.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bode L. Recent advances on structure, metabolism, and function of human milk oligosaccharides. J Nutr. 2006;136(8):2127–2130. doi: 10.1093/jn/136.8.2127.</mixed-citation><mixed-citation xml:lang="en">Bode L. Recent advances on structure, metabolism, and function of human milk oligosaccharides. J Nutr. 2006;136(8):2127–2130. doi: 10.1093/jn/136.8.2127.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Harder T, Bergmann R, Kallischnigg G, Plagemann A. Duration of breastfeeding and risk of overweight: a meta-analysis. Am J Epidemiol. 2005;162(5):397–403. doi: 10.1093/aje/kwi222.</mixed-citation><mixed-citation xml:lang="en">Harder T, Bergmann R, Kallischnigg G, Plagemann A. Duration of breastfeeding and risk of overweight: a meta-analysis. Am J Epidemiol. 2005;162(5):397–403. doi: 10.1093/aje/kwi222.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Dewey KG. Growth characteristics of breast-fed compared to formula-fed infants. Biol Neonate. 1998;74(2):94–105. doi: 10.1159/000014016.</mixed-citation><mixed-citation xml:lang="en">Dewey KG. Growth characteristics of breast-fed compared to formula-fed infants. Biol Neonate. 1998;74(2):94–105. doi: 10.1159/000014016.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ong KK, Loos RJ. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr. 2006;95(8):904–908. doi: 10.1080/08035250600719754.</mixed-citation><mixed-citation xml:lang="en">Ong KK, Loos RJ. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr. 2006;95(8):904–908. doi: 10.1080/08035250600719754.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Koletzko B, von Kries R, Closa R, et al. Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr. 2009;89(6):1836–1845. doi: 10.3945/ajcn.2008.27091.</mixed-citation><mixed-citation xml:lang="en">Koletzko B, von Kries R, Closa R, et al. Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr. 2009;89(6):1836–1845. doi: 10.3945/ajcn.2008.27091.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Weber M, Grote V, Closa-Monasterolo R, et al. Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial. Am J Clin Nutr. 2014;99(5): 1041–1051. doi: 10.3945/ajcn.113.064071.</mixed-citation><mixed-citation xml:lang="en">Weber M, Grote V, Closa-Monasterolo R, et al. Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial. Am J Clin Nutr. 2014;99(5): 1041–1051. doi: 10.3945/ajcn.113.064071.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
