vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v17i4.1918vsp-1922Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWВозможности магнитно-резонансной томографии головного мозга при детском церебральном параличеPossibilities of Magnetic Resonance Imaging of the Brain in Infantile Cerebral Palsyhttps://orcid.org/0000-0001-9719-6772БеловаА. Н.BelovaAnna N.

Нижний Новгород

 

https://orcid.org/0000-0003-0402-7430ШейкоГ. Е.SheikoGennadii E.

Шейко Геннадий Евгеньевич, кандидат медицинских наук, младший научный сотрудник отдела функциональной диагностики Университетской клиники

603155, Нижний Новгород, Верхне-Волжская набережная, д. 18

sheikogennadii@yandex.ruhttps://orcid.org/0000-0003-2069-1710КлюевЕ. А.KlyuevEvgenii А.https://orcid.org/0000-0003-4172-7444ДунаевМ. Г.DunaevMaksim G.Приволжский исследовательский медицинский университетРоссияPrivolzhskiy Research Medical UniversityRussian Federation201803102018174272278Copyright © Белова А.Н., Шейко Г.Е., Клюев Е.А., Дунаев М.Г., 20182018Белова А.Н., Шейко Г.Е., Клюев Е.А., Дунаев М.Г.Belova A.N., Sheiko G.E., Klyuev E.А., Dunaev M.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1922

Детский церебральный паралич (ДЦП) является основной причиной детской инвалидности и характеризуется непрогрессирующим поражением и/или аномалией развивающегося головного мозга у плода или новорожденного ребенка. Магнитно-резонансная томография (МРТ) представляет собой современный неинвазивный метод, обладающий широкими возможностями диагностики поражения головного мозга при ДЦП. В обзоре сделан акцент на анатомо-структурных МР-паттернах поражения головного мозга при ДЦП, представлена современная классификация МР-изменений при этом заболевании. Рассмотрена роль МРТ в установлении сроков поражения мозга при ДЦП. Представлены сведения о соотношении фенотипов ДЦП и патологических МР-находок. Обсуждаются нейровизуализационные прогностические биомаркеры. Подчеркивается, что многие вопросы в отношении прогностической значимости МР-находок остаются нерешенными, перспективы связаны с применением новых модальностей МРТ, таких как функциональная и диффузионно-тензорная МРТ.

Infantile cerebral palsy (ICP) is the main cause of childhood disability and is characterized by a non-progressive lesion and/or impaired development of the brain in a foetus or newborn. Magnetic resonance imaging (MRI) is a modern non-invasive method with extensive capabilities for diagnosing brain damage in ICP. The review focuses on anatomical structural MR patterns of brain damage in ICP and gives the present-day classification of MR changes in this disease. The role of MRI in determining the duration of brain damage in ICP has been considered. Data on the ratio of ICP phenotypes to pathological MR findings has been presented. Neuroimaging prognostic biomarkers are discussed. It is emphasized that many questions regarding the prognostic significance of MR findings remain unresolved; prospects are associated with the use of new MRI modalities such as functional and diffusiontensor MRI.

детский церебральный параличмагнитно-резонансная томографияголовной мозгнейровизуализациялучевая диагностикаinfantile cerebral palsymagnetic resonance imagingbrainneuroimagingradiologyНе указанNot specifiedReferencesRosenbaum P, Paneth N, Leviton A, et al. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl. 2007;109:8–14.Rosenbaum P, Paneth N, Leviton A, et al. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl. 2007;109:8–14.Soleimani F, Zaheri F, Abdi F. Long-term neurodevelopmental outcomes after preterm birth. Iran Red Crescent Med J. 2014; 16(6):e17965. doi: 10.5812/ircmj.17965.Soleimani F, Zaheri F, Abdi F. Long-term neurodevelopmental outcomes after preterm birth. Iran Red Crescent Med J. 2014; 16(6):e17965. doi: 10.5812/ircmj.17965.Wu YW, Croen LA, Shah SJ, et al. Cerebral palsy in a term population: risk factors and neuroimaging findings. Pediatrics. 2006; 118(2):690–697. doi: 10.1542/peds.2006-0278.Wu YW, Croen LA, Shah SJ, et al. Cerebral palsy in a term population: risk factors and neuroimaging findings. Pediatrics. 2006; 118(2):690–697. doi: 10.1542/peds.2006-0278.Yin R, Reddihough DS, Ditchfield MR, Collins KJ. Magnetic resonance imaging findings in cerebral palsy. J Paediatr Child Health. 2000;36(2):139–144. doi: 10.1046/j.1440-1754.2000.00484.x.Yin R, Reddihough DS, Ditchfield MR, Collins KJ. Magnetic resonance imaging findings in cerebral palsy. J Paediatr Child Health. 2000;36(2):139–144. doi: 10.1046/j.1440-1754.2000.00484.x.Truwit CL, Barkovich AJ, Koch TK, Ferriero DM. Cerebral palsy: MR findings in 40 patients. AJNR Am J Neuroradiol. 1992;13(1):67–78.Truwit CL, Barkovich AJ, Koch TK, Ferriero DM. Cerebral palsy: MR findings in 40 patients. AJNR Am J Neuroradiol. 1992;13(1):67–78.Steinlin M, Good M, Martin E, et al. Congenital hemiplegia: morphology of cerebral lesions and pathogenetic aspects from MRI. Neuropediatrics. 1993;24(4):224–229. doi: 10.1055/s-20081071545.Steinlin M, Good M, Martin E, et al. Congenital hemiplegia: morphology of cerebral lesions and pathogenetic aspects from MRI. Neuropediatrics. 1993;24(4):224–229. doi: 10.1055/s-20081071545.Soleimani F. Cerebral palsy and patterns of magnetic resonance imaging (MRI): a Review. Iranian Rehabilitation Journal. 2014; 12(22):59–64.Soleimani F. Cerebral palsy and patterns of magnetic resonance imaging (MRI): a Review. Iranian Rehabilitation Journal. 2014; 12(22):59–64.Krageloh-Mann I, Horber V. The role of magnetic resonance imaging in elucidating the pathogenesis of cerebral palsy: a systematic review. Dev Med Child Neurol. 2007;49(2):144–151. doi: 10.1111/j.1469-8749.2007.00144.x.Krageloh-Mann I, Horber V. The role of magnetic resonance imaging in elucidating the pathogenesis of cerebral palsy: a systematic review. Dev Med Child Neurol. 2007;49(2):144–151. doi: 10.1111/j.1469-8749.2007.00144.x.Korzeniewski J, Gretchen B, Mark C, et al. A systematic review of neuroimaging for cerebral palsy. J Child Neurol. 2008;23(2): 216–227. doi: 10.1177/0883073807307983.Korzeniewski J, Gretchen B, Mark C, et al. A systematic review of neuroimaging for cerebral palsy. J Child Neurol. 2008;23(2): 216–227. doi: 10.1177/0883073807307983.Reid SM, Dagia CD, Ditchfield MR, et al. Population-based studies of brain imaging patterns in cerebral palsy. Dev Med Child Neurol. 2014;56(3):222–32. doi: 10.1111/dmcn.12228.Reid SM, Dagia CD, Ditchfield MR, et al. Population-based studies of brain imaging patterns in cerebral palsy. Dev Med Child Neurol. 2014;56(3):222–32. doi: 10.1111/dmcn.12228.Himmelmann K, Horber V, De La Cruz J, et al. MRI classification system (MRICS) for children with cerebral palsy: development, reliability, and recommendations. Dev Med Child Neurol. 2017; 59(1):57–64. doi: 10.1111/dmcn.13166.Himmelmann K, Horber V, De La Cruz J, et al. MRI classification system (MRICS) for children with cerebral palsy: development, reliability, and recommendations. Dev Med Child Neurol. 2017; 59(1):57–64. doi: 10.1111/dmcn.13166.Ashwal S, Russman BS, Blasco PA, et al. Practice parameter: diagnostic assessment of the child with cerebral palsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2004;62(6):851–863. doi: 10.1212/01. wnl.0000117981.35364.1b.Ashwal S, Russman BS, Blasco PA, et al. Practice parameter: diagnostic assessment of the child with cerebral palsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2004;62(6):851–863. doi: 10.1212/01. wnl.0000117981.35364.1b.Faria AV, Hoon A, Stashinko E, et al. Quantitativeq analysis of brain pathology based on MRI and brain atlases — applications for cerebral Palsy. Neuroimage. 2011;54(3):1854–1861. doi: 10.1016/j.neuroimage.2010.09.061.Faria AV, Hoon A, Stashinko E, et al. Quantitativeq analysis of brain pathology based on MRI and brain atlases — applications for cerebral Palsy. Neuroimage. 2011;54(3):1854–1861. doi: 10.1016/j.neuroimage.2010.09.061.Rennie JM, Hagmann CF, Robertson NJ. Outcome after intrapartum hypoxic ischaemia at term. Semin Fetal Neonatal Med. 2007;12(5):398–407. doi: 10.1016/j.siny.2007.07.006.Rennie JM, Hagmann CF, Robertson NJ. Outcome after intrapartum hypoxic ischaemia at term. Semin Fetal Neonatal Med. 2007;12(5):398–407. doi: 10.1016/j.siny.2007.07.006.Bosanquet M, Copeland L, Ware R, Boyd R. A systematic review of tests to predict cerebral palsy in young children. Dev Med Child Neurol. 2013;55(5):418–426. doi: 10.1111/dmcn.12140.Bosanquet M, Copeland L, Ware R, Boyd R. A systematic review of tests to predict cerebral palsy in young children. Dev Med Child Neurol. 2013;55(5):418–426. doi: 10.1111/dmcn.12140.Krageloh-Mann I, Helber A, Mader I, et al. Bilateral lesions of thalamus and basal ganglia: origin and outcome. Dev Med Child Neurol. 2002;44(7):477–484. doi: 10.1111/j.1469-8749.2002. tb00309.x.Krageloh-Mann I, Helber A, Mader I, et al. Bilateral lesions of thalamus and basal ganglia: origin and outcome. Dev Med Child Neurol. 2002;44(7):477–484. doi: 10.1111/j.1469-8749.2002. tb00309.x.Himmelmann K, Uvebrant P. Function and neuroimaging in cerebral palsy: a population-based study. Dev Med Child Neurol. 2011;53(6):516–521. doi: 10.1111/j.1469-8749.2011.03932.x.Himmelmann K, Uvebrant P. Function and neuroimaging in cerebral palsy: a population-based study. Dev Med Child Neurol. 2011;53(6):516–521. doi: 10.1111/j.1469-8749.2011.03932.x.Jaspers E, Byblow WD, Feys H, Wenderoth N. The corticospinal tract: a biomarker to categorize upper limb functional potential in unilateral cerebral palsy. Front Pediatr. 2016;3:112. doi: 10.3389/fped.2015.00112.Jaspers E, Byblow WD, Feys H, Wenderoth N. The corticospinal tract: a biomarker to categorize upper limb functional potential in unilateral cerebral palsy. Front Pediatr. 2016;3:112. doi: 10.3389/fped.2015.00112.Novak I, Morgan C, Adde L, et al. Early, accurate diagnosis and early intervention in cerebral palsy: advances in diagnosis and treatment. JAMA Pediatr. 2017;171(9):897–907. doi: 10.1001/jamapediatrics.2017.1689.Novak I, Morgan C, Adde L, et al. Early, accurate diagnosis and early intervention in cerebral palsy: advances in diagnosis and treatment. JAMA Pediatr. 2017;171(9):897–907. doi: 10.1001/jamapediatrics.2017.1689.Baker LL, Stevenson DK, Enzmann DR. End-stage periventricular leukomalacia: MR evaluation. Radiology. 1988;168(3):809–815. doi: 10.1148/radiology.168.3.3406411.Baker LL, Stevenson DK, Enzmann DR. End-stage periventricular leukomalacia: MR evaluation. Radiology. 1988;168(3):809–815. doi: 10.1148/radiology.168.3.3406411.Yokochi K, Aiba K, Horie M, et al. Magnetic resonance imaging in children with spastic diplegia: correlation with the severity of their motor and mental abnormality. Dev Med Child Neurol. 1991; 33(1):18–25. doi: 10.1111/j.1469-8749.1991.tb14781.x.Yokochi K, Aiba K, Horie M, et al. Magnetic resonance imaging in children with spastic diplegia: correlation with the severity of their motor and mental abnormality. Dev Med Child Neurol. 1991; 33(1):18–25. doi: 10.1111/j.1469-8749.1991.tb14781.x.Lee RW, Poretti A, Cohen JS, et al. A diagnostic approach for cerebral palsy in the genomic era. Neuromolecular Med. 2014; 16(4):821–844. doi:10.1007/s12017-014-8331-9.Lee RW, Poretti A, Cohen JS, et al. A diagnostic approach for cerebral palsy in the genomic era. Neuromolecular Med. 2014; 16(4):821–844. doi:10.1007/s12017-014-8331-9.Kwong K, Wong Y, Fong C. Magnetic resonance imaging in 122 children with spastic cerebral palsy. Pediatric Neurology. 2004;31(3):172–175. doi: 10.1016/j.pediatrneurol.2004.02.005.Kwong K, Wong Y, Fong C. Magnetic resonance imaging in 122 children with spastic cerebral palsy. Pediatric Neurology. 2004;31(3):172–175. doi: 10.1016/j.pediatrneurol.2004.02.005.Barkovich AJ, Truwit CL. Brain damage from perinatal asphyxia: correlation of MR findings with gestational age. AJNR Am J Neuroradiol. 1990;11(6):1087–96.Barkovich AJ, Truwit CL. Brain damage from perinatal asphyxia: correlation of MR findings with gestational age. AJNR Am J Neuroradiol. 1990;11(6):1087–96.Towsley K, Shevell MI, Dagenais L; REPACQ Consortium. Population-based study of neuroimaging findings in children with cerebral palsy. Eur J Paediatr Neurol. 2011;15(1):29–35. doi: 10.1016/j.ejpn.2010.07.005.Towsley K, Shevell MI, Dagenais L; REPACQ Consortium. Population-based study of neuroimaging findings in children with cerebral palsy. Eur J Paediatr Neurol. 2011;15(1):29–35. doi: 10.1016/j.ejpn.2010.07.005.Himmelmann K, Hagberg G, Uvebrant P. The changing panorama of cerebral palsy in Sweden. X. Prevalence and origin in the birthyear period 1999–2002. Acta Paediatr. 2010;99(9):1337–1343. doi: 10.1111/j.1651-2227.2010.01819.x.Himmelmann K, Hagberg G, Uvebrant P. The changing panorama of cerebral palsy in Sweden. X. Prevalence and origin in the birthyear period 1999–2002. Acta Paediatr. 2010;99(9):1337–1343. doi: 10.1111/j.1651-2227.2010.01819.x.Benders MJ, Groenendaal F, De Vries LS. Preterm arterial ischemic stroke. Semin Fetal Neonatal Med 2009;14(5):272–277. doi: 10.1016/j.siny.2009.07.002.Benders MJ, Groenendaal F, De Vries LS. Preterm arterial ischemic stroke. Semin Fetal Neonatal Med 2009;14(5):272–277. doi: 10.1016/j.siny.2009.07.002.Reid SM, Ditchfield MR, Bracken J, Reddihough DS. Relationship between characteristics on magnetic resonance imaging and motor outcomes in children with cerebral palsy and white matter injury. Res Dev Disabil. 2015;45–46:178–187. doi: 10.1016/ j.ridd.2015.07.030.Reid SM, Ditchfield MR, Bracken J, Reddihough DS. Relationship between characteristics on magnetic resonance imaging and motor outcomes in children with cerebral palsy and white matter injury. Res Dev Disabil. 2015;45–46:178–187. doi: 10.1016/ j.ridd.2015.07.030.Numata A, Onuma A, Kobayashi Y, et al. Brain magnetic resonance imaging and motor and intellectual functioning in 86 patients born at term with spastic diplegia. Dev Med Child Neurol. 2013;55(2):167–172. doi: 10.1111/dmcn.12013.Numata A, Onuma A, Kobayashi Y, et al. Brain magnetic resonance imaging and motor and intellectual functioning in 86 patients born at term with spastic diplegia. Dev Med Child Neurol. 2013;55(2):167–172. doi: 10.1111/dmcn.12013.Krageloh-Mann I, Petersen D, Hagberg G, et al. Bilateral spastic cerebral palsy — MRI pathology and origin. Analysis from a representative series of 56 cases. Dev Med Child Neurol. 1995;37(5):379–397. doi: 10.1111/j.1469-8749.1995.tb12022.x.Krageloh-Mann I, Petersen D, Hagberg G, et al. Bilateral spastic cerebral palsy — MRI pathology and origin. Analysis from a representative series of 56 cases. Dev Med Child Neurol. 1995;37(5):379–397. doi: 10.1111/j.1469-8749.1995.tb12022.x.Krageloh-Mann I. Imaging of early brain injury and cortical plasticity. Exp Neurol. 2004;190 Suppl 1:84–91. doi: 10.1016/ j.expneurol.2004.05.037.Krageloh-Mann I. Imaging of early brain injury and cortical plasticity. Exp Neurol. 2004;190 Suppl 1:84–91. doi: 10.1016/ j.expneurol.2004.05.037.Bax M, Tydeman A, Flodmark O. Clinical and MRI correlates of cerebral palsy: the European Cerebral Palsy Study. JAMA. 2006;296(13):1602–1609. doi: 10.1001/jama.296.13.1602.Bax M, Tydeman A, Flodmark O. Clinical and MRI correlates of cerebral palsy: the European Cerebral Palsy Study. JAMA. 2006;296(13):1602–1609. doi: 10.1001/jama.296.13.1602.Shevell M, Miller S. Acquired brain injury in the fetus and newborn. 1st ed. London, UK: Mac Keith Press; 2012. 318 p.Shevell M, Miller S. Acquired brain injury in the fetus and newborn. 1st ed. London, UK: Mac Keith Press; 2012. 318 p.Krageloh-Mann I, Cans C. Cerebral palsy update. Brain Dev. 2009;31(7):537–544. doi: 10.1016/j.braindev.2009.03.009.Krageloh-Mann I, Cans C. Cerebral palsy update. Brain Dev. 2009;31(7):537–544. doi: 10.1016/j.braindev.2009.03.009.Eyre JA, Taylor JP, Villagra F, et al. Evidence of activity-dependent withdrawal of corticospinal projections during human development. Neurology. 2001;57(9):1543–1554. doi: 10.1212/WNL.57.9.1543.Eyre JA, Taylor JP, Villagra F, et al. Evidence of activity-dependent withdrawal of corticospinal projections during human development. Neurology. 2001;57(9):1543–1554. doi: 10.1212/WNL.57.9.1543.Feys H, Eyssen M, Jaspers E, et al. Relation between neuroradiological findings and upper limb function in hemiplegic cerebral palsy. Eur J Paediatr Neurol. 2010;14(2):169–177. doi: 10.1016/j.ejpn.2009.01.004.Feys H, Eyssen M, Jaspers E, et al. Relation between neuroradiological findings and upper limb function in hemiplegic cerebral palsy. Eur J Paediatr Neurol. 2010;14(2):169–177. doi: 10.1016/j.ejpn.2009.01.004.Kumura A, Hayakawa F, Kato T, et al. MRI findings in patients with spastic cerebral palsy. I: correlation with gestational age at birth. Dev Med Child Neurol. 1997;39(6):363–368. doi: 10.1111/j.1469-8749.1997.tb07447.x.Kumura A, Hayakawa F, Kato T, et al. MRI findings in patients with spastic cerebral palsy. I: correlation with gestational age at birth. Dev Med Child Neurol. 1997;39(6):363–368. doi: 10.1111/j.1469-8749.1997.tb07447.x.Brody BA, Kinney HC, Kloman AS, Gilles FH. Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination. J Neuropathol Exp Neurol. 1987;46(3):283–301. doi: 10.1097/00005072-198705000-00005.Brody BA, Kinney HC, Kloman AS, Gilles FH. Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination. J Neuropathol Exp Neurol. 1987;46(3):283–301. doi: 10.1097/00005072-198705000-00005.Staudt M, Gerloff C, Grodd W, et al. Reorganization in congenital hemiparesis acquired at different gestational ages. Ann Neurol. 2004;56(6):854–63. doi: 10.1002/ana.20297.Staudt M, Gerloff C, Grodd W, et al. Reorganization in congenital hemiparesis acquired at different gestational ages. Ann Neurol. 2004;56(6):854–63. doi: 10.1002/ana.20297.Kagen J, Herschkowitz N. A young mind in a growing brain. London, UK: Psychology Press; 2006. 336 p.Kagen J, Herschkowitz N. A young mind in a growing brain. London, UK: Psychology Press; 2006. 336 p.Комплексная оценка двигательных функций у пациентов с детским церебральным параличом. Учебно-методическое пособие / Под ред. Баранова А.А., Намазовой-Барановой Л.С., Куренкова А.Л., и др. — М.: ПедиатрЪ; 2014. — 84 с.Kompleksnaya otsenka dvigatel’nykh funktsii u patsientov s detskim tserebral’nym paralichom. Uchebno-metodicheskoe posobie. Ed by Baranov A.A., Namazova-Baranova L.S., Kurenkov A.L., et al. Moscow: Pediatr”; 2014. 84 p. (In Russ).Derinkuyu BE, Ozmen E, Akmaz-Unlu H, et al. A magnetic resonance imaging finding in children with cerebral palsy: symmet rical central tegmental tract hyperintensity. Brain Dev. 2017; 39(3):211–217. doi: 10.1016/j.braindev.2016.10.004.Derinkuyu BE, Ozmen E, Akmaz-Unlu H, et al. A magnetic resonance imaging finding in children with cerebral palsy: symmet rical central tegmental tract hyperintensity. Brain Dev. 2017; 39(3):211–217. doi: 10.1016/j.braindev.2016.10.004.Залялова З.А., Аюпова В.А. Клинико-МРТ анализ пациентов с гиперкинетической формой детского церебрального паралича // Неврологический вестник. Журнал им. В.М. Бехтерева. — 2004. — Т. 36. — № 1–2 — С. 21–26.Zalalova ZA, Ajupova VA. A clinical MRT-examination of patients with a hyperkinetic form of infantile cerebral paralysis. Nevrologicheskii vestnik. 2004; 36(1–2):21–26. (In Russ).Баранов А.А., Намазова-Баранова Л.С., Кузенкова Л.М., и др. Детский церебральный паралич у детей. Клинические рекомендации. — М.: 2017. — 62 с. Доступно по: http://www.pediatr-russia.ru/sites/default/files/kr_dcp.pdf Ссылка активна на 24.06.2018.Baranov AA, NamazovaBaranova LS, Kuzenkova LM, et al. Detskii tserebral’nyi paralich u detei. Klinicheskie rekomendatsii. Moscow: 2017. 62 p. (In Russ). http://www.pediatr-russia.ru/sites/default/files/kr_dcp.pdfБатышева Т.Т. Детский церебральный паралич и эпилепсия. Современные подходы к лечению. Методические рекомендации № 27. — М.: Научный центр детской психоневрологии; 2016. — 24 с.Batysheva TT. Detskii tserebral’nyi paralich i epilepsiya. Sovremennye podkhody k lecheniyu. Metodicheskie rekomendatsii № 27. Moscow: Nauchnyi tsentr detskoi psikhonevrologii; 2016. 24 p. (In Russ).Barkovich AJ, Hajnal BL, Vigneron D, et al. Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. AJNR Am J Neuroradiol. 1998;19(1):143–149.Barkovich AJ, Hajnal BL, Vigneron D, et al. Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. AJNR Am J Neuroradiol. 1998;19(1):143–149.Rutherford M, Ramenghi LA, Edwards AD, et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol. 2010;9(1):39–45. doi: 10.1016/S1474-4422(09)70295-9.Rutherford M, Ramenghi LA, Edwards AD, et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol. 2010;9(1):39–45. doi: 10.1016/S1474-4422(09)70295-9.Weeke LC, Groenendaal F, Mudigonda K, et al. A novel magnetic resonance imaging score predicts neurodevelopmental outcome after perinatal asphyxia and therapeutic hypothermia. J Pediatr. 2018;192:33–40. doi: 10.1016/j.jpeds.2017.09.043.Weeke LC, Groenendaal F, Mudigonda K, et al. A novel magnetic resonance imaging score predicts neurodevelopmental outcome after perinatal asphyxia and therapeutic hypothermia. J Pediatr. 2018;192:33–40. doi: 10.1016/j.jpeds.2017.09.043.George JM, Pannek K, Rose SE, et al. Diagnostic accuracy of early magnetic resonance imaging to determine motor outcomes in infants born preterm: a systematic review and meta-analysis. Dev Med Child Neurol. 2018;60(2):134–146. doi: 10.1111/dmcn.13611.George JM, Pannek K, Rose SE, et al. Diagnostic accuracy of early magnetic resonance imaging to determine motor outcomes in infants born preterm: a systematic review and meta-analysis. Dev Med Child Neurol. 2018;60(2):134–146. doi: 10.1111/dmcn.13611.Holmefur M, Kits A, Bergstrom J, et al. Neuroradiology can predict the development of hand function in children with unilateral cerebral palsy. Neurorehabil Neural Repair. 2013;27(1):72–78. doi: 10.1177/1545968312446950.Holmefur M, Kits A, Bergstrom J, et al. Neuroradiology can predict the development of hand function in children with unilateral cerebral palsy. Neurorehabil Neural Repair. 2013;27(1):72–78. doi: 10.1177/1545968312446950.Eyre JA, Smith M, Dabydeen L, et al. Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system? Ann Neurol. 2007;62(5):493–503. doi: 10.1002/ana.21108.Eyre JA, Smith M, Dabydeen L, et al. Is hemiplegic cerebral palsy equivalent to amblyopia of the corticospinal system? Ann Neurol. 2007;62(5):493–503. doi: 10.1002/ana.21108.Staudt M. Reorganization after preand perinatal brain lesions. J Anat. 2010;217(4):469–474. doi: 10.1111/j.14697580.2010.01262.x.Staudt M. Reorganization after preand perinatal brain lesions. J Anat. 2010;217(4):469–474. doi: 10.1111/j.14697580.2010.01262.x.Hoon AH Jr, Stashinko EE, Nagae LM, et al. Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways. Dev Med Child Neurol. 2009;51(9):697–704. doi: 10.1111/j.14698749.2009.03306.x.Hoon AH Jr, Stashinko EE, Nagae LM, et al. Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways. Dev Med Child Neurol. 2009;51(9):697–704. doi: 10.1111/j.14698749.2009.03306.x.Аминов Х.Д., Икрамов А.И. Функциональныe методы нейровизуализации при детском церебральном параличе // Международный журнал прикладных фундаментальных исследований. — 2015. — № 1–1 — С. 25–28.Aminov HD, Ikramov AI. Functional imaging methods in diagnostics of cerebral palsy. Mezhdunarodnyi zhurnal prikladnykh fundamental’nykh issledovanii. 2015;(1–1):25–28. (In Russ).Chinier E, N’Guyen S, Lignon G, et al. Effect of motor imagery in children with unilateral cerebral palsy: fMRI study. PLoS One. 2014;9(4):e93378. doi: 10.1371/journal.pone.0093378.Chinier E, N’Guyen S, Lignon G, et al. Effect of motor imagery in children with unilateral cerebral palsy: fMRI study. PLoS One. 2014;9(4):e93378. doi: 10.1371/journal.pone.0093378.Шестова Е.П., Евтушенко С.К., Соловьева Е.М., Душацкая А.В. Аномалии головного мозга (миграционные нарушения) у детей: клинико-радиологические проявления // Международный неврологический журнал. — 2005. — № 4 — С. 30–36.Shestova EP, Evtushenko SK, Solov’eva EM, Dushatskaya AV. Anomalii golovnogo mozga (migratsionnye narusheniya) u detei: kliniko-radiologicheskie proyavleniya. International neurological journal. 2005;(4):30–36. (In Russ).

The authors declare that there are no conflicts of interest present.