vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v17i4.1920vsp-1924Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWРоль железа в патогенезе расстройств аутистического спектра у детейThe Role of Iron in the Pathogenesis of Autism Spectrum Disorders in Childrenhttps://orcid.org/0000-0001-7529-2544КостинаО. В.KostinaOlga V.

Костина Ольга Владимировна, кандидат биологических наук, старший научный сотрудник лаборатории биохимии и неотложной диагностики ПИМУ

603155, Нижний Новгород, Верхне-Волжская наб., д. 18/1

olkosta@rambler.ruПриволжский исследовательский медицинский университетРоссияPrivolzhskiy Research Medical UniversityRussian Federation201804102018174281286Copyright © Костина О.В., 20182018Костина О.В.Kostina O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1924

В обзоре представлен анализ механизмов влияния железа на развитие головного мозга. Рассматривается значимость дефицита железа в перинатальном периоде как фактора риска возникновения психоневрологических нарушений у детей с расстройствами аутистического спектра (РАС). Обсуждаются возможные причины сидеропении; представлены данные исследований гематологических и биохимических параметров, характеризующих обмен железа у детей с РАС. Отмечена необходимость изучения роли дисбаланса обмена железа в развитии психоневрологических нарушений для уточнения патогенетических механизмов РАС и определения способов их коррекции.

The review presents an analysis of the mechanisms of iron effect on the brain development. The importance of iron deficiency in the perinatal period is considered as a risk factor for the development of neuropsychiatric disorders in children with autism spectrum disorders (ASDs). Possible causes of sideropenia are discussed; data on haematological and biochemical parameters characterizing iron metabolism in children with ASDs are presented. The demand for studying the role of iron metabolism imbalance in the development of neuropsychiatric disorders in order to clarify pathogenetic mechanisms of ASDs and to determine methods for their correction is emphasized.

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The authors declare that there are no conflicts of interest present.