vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v17i6.1975vsp-1976Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWГолимумаб в лечении хронических воспалительных заболеваний суставов во взрослой популяции: клиническая эффективность и переносимостьGolimumab for Treating Chronic Inflammatory Joint Diseases in the Adult Population: Clinical Efficacy and Tolerabilityhttps://orcid.org/0000-0001-8051-8659ЧичасоваН. В.ChichasovaNatal’ya N.

доктор медицинских наук, профессор кафедры ревматологии

115522, Каширское ш., д. 34А

 

kafedrarheum@yandex.ruПервый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет) Научно-исследовательский институт ревматологии им. В.А. НасоновойРоссияI.M. Sechenov First Moscow State Medical University (Sechenov University) V.A. Nasonova Research Institute of RheumatologyRussian Federation201830012019176449457Copyright © Чичасова Н.В., 20192019Чичасова Н.В.Chichasova N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/1976

В связи с недавним вводом голимумаба в педиатрическую ревматологическую практику представлен обзор результатов клинических исследований данного ингибитора фактора некроза опухоли альфа, большинство из которых проведено с участием взрослых больных с ревматическими заболеваниями. Анализируются клинико-лабораторные эффекты и переносимость голимумаба в виде подкожных инъекций при ревматоидном артрите, псориатическом артрите и спондилитах. Обсуждаются оценки эффективности и переносимости препарата в длительных — до 5 лет — наблюдательных исследованиях.

Due to the recent introduction of golimumab into paediatric rheumatology practice, an overview of the clinical studies of this tumour necrosis factor alpha inhibitor, most of which were conducted with adult patients with rheumatic diseases, has been presented. Clinical laboratory effects and tolerability of golimumab in the form of subcutaneous injections have been analysed for rheumatoid arthritis, psoriatic arthritis, and spondylitis. Evaluation of the efficacy and tolerability of golimumab in long-term observational studies (up to 5 years) has been discussed.

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The authors declare that there are no conflicts of interest present.