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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/vsp.v18i3.2039</article-id><article-id custom-type="elpub" pub-id-type="custom">vsp-2141</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERT OPINION</subject></subj-group></article-categories><title-group><article-title>Полипрагмазия в педиатрической практике: современные реалии</article-title><trans-title-group xml:lang="en"><trans-title>Polypharmacy in Pediatrics: Modern Conditions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6528-1585</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>Natalia B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лазарева Наталья Борисовна, доктор медицинских наук, профессор кафедры клинической фармакологии и пропедевтики внутренних болезней</p></bio><email xlink:type="simple">natalia.lazareva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6589-7654</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ших</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shikh</surname><given-names>Evgenia V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4374-9754</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Реброва</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rebrova</surname><given-names>Ekaterina V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4778-5015</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рязанова</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryazanova</surname><given-names>Anastasia Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Волгоградский государственный медицинский университет,</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>18</day><month>09</month><year>2019</year></pub-date><volume>18</volume><issue>3</issue><fpage>212</fpage><lpage>218</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лазарева Н.Б., Ших Е.В., Реброва Е.В., Рязанова А.Ю., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Лазарева Н.Б., Ших Е.В., Реброва Е.В., Рязанова А.Ю.</copyright-holder><copyright-holder xml:lang="en">Lazareva N.B., Shikh E.V., Rebrova E.V., Ryazanova A.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/2141">https://vsp.spr-journal.ru/jour/article/view/2141</self-uri><abstract><p>Полипрагмазия как причина ятрогении является серьезной проблемой здравоохранения как в мире, так и, предполагаемо, в России. Клинически полипрагмазия проявляется снижением эффективности фармакотерапии и развитием тяжелых нежелательных лекарственных реакций, а также значительным увеличением расходов на цели здравоохранения. Единого определения полипрагмазии в педиатрической практике не существует. При этом обычно учитывают количество и продолжительность приема лекарств, классы лекарственных препаратов, пригодность лекарств, состояние здоровья и клинические условия. Актуальным остается изучение связи существующих моделей назначения лекарственных препаратов с возникновением нарушений здоровья у детей. В обзоре изложены результаты современных исследований по этой проблеме.</p></abstract><trans-abstract xml:lang="en"><p>The polypharmacy as the reason of iatrogeny is topical problem of health care both in Russia and in the world. Clinical aspects of polypharmacy come out as pharmacotherapy efficiency decrease and development of severe adverse drug effects as well as health care cost increase. There is no uniform definition of polypharmacy in pediatric practice. However quantity and duration of medicine administration, medicine class, medicine eligibility, medical conditions and clinical conditions are usually considered. The correlations between existing medicines prescription models and health problems in children appears relevant. The results of recent researches on this problem are presented in the review.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>полипрагмазия</kwd><kwd>дети</kwd><kwd>педиатрия</kwd><kwd>безопасность</kwd><kwd>лекарственные средства</kwd><kwd>фармакоэпидемиология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>polypharmacy</kwd><kwd>children</kwd><kwd>pediatrics</kwd><kwd>safety</kwd><kwd>medicines</kwd><kwd>pharmacoepidemiology</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Not specified.</funding-statement><funding-statement xml:lang="en">Not specified.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Сычёв Д.А., Отделенов В.А., Краснова Н.М., Ильина Е.С. 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