vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v13i1.908vsp-223Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWЭФФЕКТИВНОСТЬ ПНЕВМОКОККОВЫХ КОНЪЮГИРОВАННЫХ ВАКЦИН СЛЕДУЮЩЕГО ПОКОЛЕНИЯ В РАЗНЫХ РЕГИОНАХ МИРАNEXT GENERATION PNEUMOCOCCAL CONJUGATE VACCINES EFFICACY AND EFFECTIVENESS IN DIFFERENT REGIONS OF THE WORLDКовтунО. П.KovtunO. P.

PhD, Head of Pediatrics and Neonatology Department of the Faculty Training and Retraining, Vice-rector for Scientific Research of Ural State Medical University (USMU), Chief Pediatrician of the Ural Federal Region (UrFR), Director of the Sverdlovsk affiliate of Research Center for Children’s Health RAMS

kovtun@usma.ruРоманенкоВ. В.RomanenkoV. V.kovtun@usma.ruУральский государственный медицинский университет, ЕкатеринбургРоссияUral State Medical University, EkaterinburgRussian Federation201411012014131Вопросы современной педиатрии1825Copyright © Ковтун О.П., Романенко В.В., 20142014Ковтун О.П., Романенко В.В.Kovtun O.P., Romanenko V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/223

Приводится обзор последних публикаций и текстов докладов по клиническим исследованиям и данным эффективности применения 10- и 13-валентной пневмококковых конъюгированных вакцин (ПКВ10 и 13) в разных странах мира для прогнозирования ожидаемого эффекта массовой иммунизации детей в России в связи с включением вакцинации против пневмококковой инфекции в Национальный календарь прививок c 1 января 2014 г. На основе проанализированных данных сделан вывод о высокой эффективности указанных вакцин в отношении инвазивных пневмококковых инфекций (ИПИ) при использовании схемы 3+1. Эффективность в отношении ИПИ при схеме 2+1 для ПКВ10 определена на уровне 85,8% (Финляндия), для ПКВ13 — 100% (Норвегия). Серотип-специфическая эффективность в отношении ИПИ для ПКВ10 определена только по серотипам 6В и 14, в то время как для ПКВ13 продемонстрирована при схемах 2+1 и 3+1 не только по общим с 7-валентной пневмококковой конъюгированной вакциной (ПКВ7) серотипам, но и в отношении дополнительных серотипов 1, 6А, 7F, 19А. По сравнению с ПКВ7, в отношении пневмоний и средних отитов ПКВ10 не показала дополнительных преимуществ (исследования COMPAS и FinIP), в то время как ПКВ13 продемонстрировала дальнейшее снижение заболеваемости и более высокую эффективность в отношении этих заболеваний (США, Израиль, Франция, Уругвай, Аргентина, ЮАР). Стойкое, выраженное и статистически достоверное снижение носительства вакцинальных серотипов и популяционный эффект (снижение заболеваемости ИПИ в невакцинированной популяции) продемонстрированы пока только для ПКВ13 (США, Англия и Уэльс, Израиль, Франция, Норвегия).

 

In the article latest published and presented data on 10- and 13-valent pneumococcal conjugate vaccines (PCV10 and PCV13) efficacy and effectiveness in different regions of the world overview is provided for prognosis of expected effect of Russian infants mass immunization as anti-pneumococcal vaccination has been included into the National immunization program in Russia since January 1, 2014. Based on analyzed data conclusion about PCV10 and PCV13 high effectiveness against invasive pneumococcal diseases (IPD) in 3+1 schedule has been made. PCV10 effectiveness against IPD in 2+1 schedule has been determined as 85,8% (Finland), for PCV13 — 100% (Norway). Serotype-specific effectiveness for IPD has been established for PCV10 only for serotypes 6B and 14, at the same time PCV13 serotype-specific effectiveness in 3+1 and 2+1 schedules has been established not only for PCV7-common serotypes, but for additional serotypes 1, 6А, 7F, 19А. In comparison with PCV7 efficacy and effectiveness against pneumonia and otitis media PCV10 has not shown additional benefits (in COMPAS and FinIP trials), at the same time PCV13 has demonstrated subsequent decreasing and additional effectiveness against these diseases (USA, Israel, France, Uruguay, Argentina, South Africa). Sustained and apparent statistically significant nasopharyngeal carriage reduction and herd effect (decreasing of IPD in non-vaccinated part of the population) have been established only for PCV13 (USA, England and Wales, Israel, France).

 

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The authors declare that there are no conflicts of interest present.