References

vsp

Вопросы современной педиатрии

Current Pediatrics

1682-55271682-5535

Издательство «ПедиатрЪ»

10.15690/vsp.v19i2.2104

vsp-2377

Research Article

ОБЗОР ЛИТЕРАТУРЫ

REVIEW

Биологическая терапия в эру COVID-19

Biological Therapy During COVID-19

https://orcid.org/0000-0002-2209-7531

Намазова-Баранова

Л. С.

Namazova-Baranova

Leyla S.

Москва.

Moscow.

https://orcid.org/0000-0003-2252-8570

Мурашкин

Н. Н.

Murashkin

Nikolay N.

Мурашкин Николай Николаевич - доктор медицинских наук, заведующий отделением дерматологии с группой лазерной хирургии, заведующий лабораторией патологии кожи у детей отдела научных исследований в педиатрии НМИЦ здоровья детей, профессор кафедры дерматовенерологии и косметологии ЦГМА, профессор кафедры педиатрии и детской ревматологии Первого МГМУ им. И.М. Сеченова.

119296, Москва, Ломоносовский проспект, д. 2, стр. 1.

тел.: +7 (495) 967-14-20

Moscow.

m_nn2001@mail.ru

https://orcid.org/0000-0002-0081-0981

Иванов

Р. А.

Ivanov

Roman A.

Москва.

Центральная клиническая больница РАН; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияCentral Clinical Hospital of the Russian Academy of Sciences; Pirogov Russian National Research Medical UniversityRussian Federation

Центральная клиническая больница РАН; Национальный медицинский исследовательский центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Центральная государственная медицинская академия Управления делами ПрезидентаРоссияCentral Clinical Hospital of the Russian Academy of Sciences; National Medical Research Center for Children's Health; Sechenov First Moscow State Medical University (Sechenov University); Central State Medical Academy of Presidential AdministrationRussian Federation

Центральная государственная медицинская академия Управления делами ПрезидентаРоссияCentral State Medical Academy of Presidential AdministrationRussian Federation

2020

21062020

192116122

2020

Намазова-Баранова Л.С., Мурашкин Н.Н., Иванов Р.А.

Namazova-Baranova L.S., Murashkin N.N., Ivanov R.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://vsp.spr-journal.ru/jour/article/view/2377

В связи с широким применением генно-инженерных биологических препаратов (ГИБП) в лечении иммуноопосредованных воспалительных заболеваний остро встает вопрос о дальнейшей терапевтической тактике ведения таких пациентов с учетом тяжелой эпидемиологической обстановки, вызванной пандемией нового коронавируса SARS-CoV-2. В обзоре собраны актуальные данные о патогенезе COVID-19 с развитием острого респираторного дистресс-синдрома, обусловленного синдромом высвобождения цитокинов («цитокиновый шторм»). Рассматриваются влияние ГИБП на патогенез COVID-19 и их роль в лечении тяжелых форм COVID-19. В обзоре отражены последние рекомендации международных ассоциаций/консенсусов и наблюдения врачей различных специальностей по вопросу прерывания/продолжения терапии ГИБП с оценкой последствий в случае прерывания биологической терапии.

There is crucial question on further therapeutic tactics for the management of such patients (within the severe epidemiological situation caused by the pandemic of new coronavirus SARS-CoV-2) due to widespread application of genetically engineered biologic drugs (GEBD)in management of immune mediated inflammatory diseases. This review sums up current data on the pathogenesis of COVID-19 with the development of acute respiratory distress syndrome associated with cytokine release syndrome (cytokine storm). The effects of GEBD on COVID-19 pathogenesis and their role in management of COVID-19 severe forms of are considered. This review presents the latest guidelines of international associations/consensus and observations of doctors of various specialties on the issue of interruption/continuation of GEBD therapy and with further consequence evaluation in case of interruption of biological therapy.

генно-инженерные биологические препаратыSARS-CoV-2COVID-19синдром высвобождения цитокинов«цитокиновый шторм»острый респираторный дистресс-синдромTNFαIL1IL6IL17IL23янус-киназы

genetically engineered biologic drugsSARS-CoV-2COVID-19cytokine release syndromecytokine stormacute respiratory distress syndromeTNFαIL1IL6IL17IL23janus kinase

Не указан.

Not specified.

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The authors declare that there are no conflicts of interest present.