<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/vsp.v13i1.925</article-id><article-id custom-type="elpub" pub-id-type="custom">vsp-240</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ  ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>A DOCTOR’S AID</subject></subj-group></article-categories><title-group><article-title>НОВОРОЖДЕННЫЕ ГРУППЫ ВЫСОКОГО РИСКА И ЭЛЕКТРОФИЗИОЛОГИЧЕСКАЯ АКТИВНОСТЬ СЕРДЦА В ПЕРИОД РАННЕЙ АДАПТАЦИИ</article-title><trans-title-group xml:lang="en"><trans-title>NEWBORNS OF HIGH RISK GROUPS AND ELECTROPHYSIOLOGICAL CARDIAC ACTIVITY DURING THE PERIOD OF EARLY ADAPTATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тумаева</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tumaeva</surname><given-names>T. S.</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, Head of the Department of Functional Diagnostics of Mordovia Republic’s Perinatral Clinical Centre</p></bio><email xlink:type="simple">tstumaeva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балыкова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balykova</surname><given-names>L. A.</given-names></name></name-alternatives><email xlink:type="simple">tstumaeva@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Мордовский республиканский клинический перинатальный центр, Саранск, Республика Мордовия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mordvinian Republican Clinical Perinatal Center, Saransk, Republic of Mordovia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Мордовский государственный университет им. Н.П. Огарева, Саранск, Республика Мордовия</institution><country>Russian Federation</country></aff><aff xml:lang="en"><institution>N.P.Ogarev Mordvinian State University, Saransk, Republic of Mordovia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>11</day><month>01</month><year>2014</year></pub-date><volume>13</volume><issue>1</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>141</fpage><lpage>146</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тумаева Т.С., Балыкова Л.А., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Тумаева Т.С., Балыкова Л.А.</copyright-holder><copyright-holder xml:lang="en">Tumaeva T.S., Balykova L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/240">https://vsp.spr-journal.ru/jour/article/view/240</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: изучить особенности электрофизиологической активности сердца у детей группы риска, оценить возможности холтеровского мониторирования электрокардиограммы (ХМ ЭКГ) в выявлении дисфункции сердца в периоде ранней адаптации. Пациенты и методы: обследовано 250 новорожденных. Основная группа — 200 детей с церебральной ишемией (ЦИ). В ней выделено 2 подгруппы: 100 доношенных и 100 недоношенных различного срока гестации. Контрольная группа — 50 детей, рожденных в 38–40 нед гестации от физиологичных беременности и родов с оценкой по шкале Апгар 8–9 баллов. Комплексное обследование включало ХМ ЭКГ по стандартной методике с оценкой частоты сердечных сокращений (ЧСС) сна, бодрствования; ЧССmin, ЧССmax; нарушений ритма, проводимости, длительности пауз; вариабельности ритма. Результаты: по данным ЭКГ, у детей с ЦИ, особенно недоношенных, и у детей после кесарева сечения чаще встречались ST–T нарушения, нарушения ритма (синусовая тахи- или, реже, брадикардия) и проводимости, удлинение продолжительности Q–Tc. По данным ХМ ЭКГ, у детей с ЦИ, особенно после кесарева сечения, выявлено снижение ЧСС сна, ЧССmin, ЧССmax. Среди нарушений ритма преобладала наджелудочковая экстрасистолия. Паузы ритма, показатели вариабельности были наиболее повышены у недоношенных после кесарева сечения. Выводы: гипоксия / ишемия служит пусковым фактором развития дисфункции сердечно-сосудистой системы новорожденных. Группу высокого риска составляют недоношенные, дети, рожденные путем кесарева сечения. Проведение ХМ ЭКГ расширяет возможности выявления признаков кардиальной дисфункции (нарушений базального уровня функционирования, адаптационных возможностей синусового узла, электрической нестабильности миокарда, аритмий, нарушений вариабельности сердечного ритма) у детей из группы риска по формированию патологии сердечно-сосудистой системы.</p></sec><sec><title> </title><p> </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim: to study characteristics of electrophysiological cardiac activity in children of risk groups and to assess possibilities of Holter-electrocardiography (H-ECG) in revealing of cardiac dysfunction during the period of early adaptation. Patients and methods: 250 newborns were examined. The main group consisted of 200 children with cerebral ischemia (CI). This group was divided into 2 subgroups: 100 full-term and 100 premature (at various gestation age) infants. Control group contained 50 children born at 38–40th weeks of gestation with physiological course of pregnancy and delivery, APGAR score of 8–9 points. Complex examination included H-ECG according the standard technic with evaluation of the hearth rate (HR) during sleep and wakefulness; HRmin, HRmax; arrhythmias, conductivity disorders, duration of the intervals; rhythm variability. Results: according to the ECG children with CI, especially premature ones, and children delivered via Cesarean section more often had ST-T disturbances, arrhythmias (sinus tachycardia, less often — sinus bradycardia) and conductivity disorders, Q-Tc prolongation. H-EGC revealed decrease of sleep HR, HRmin and HRmax in children with CI especially in delivered via Cesarean section. The most common arrhythmia was supraventricular extrasystole.  Pauses in rhythms and variability were the highest in premature children delivered via Cesarean section. Conclusions: hypoxia/ischemia is a trigger for development of cardiovascular dysfuncion in newborns. Premature and children delivered via Cesarean section form a group of high risk. H-ECG widens possibilities of revealing of symptoms of cardiac dysfunction (disturbances at the basal level of functioning, of adaptation resources of the sinus node, electric instability of the myocardium and heart rate variability) in children of risk group for development of cardiovascular disorders.</p></sec><sec><title> </title><p> </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>новорожденные</kwd><kwd>гипоксия / ишемия</kwd><kwd>кесарево сечение</kwd><kwd>сердечно-сосудистая система</kwd><kwd>холтеровское мониторирование электрокардиограммы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>newborns</kwd><kwd>hypoxia/ischemia</kwd><kwd>Cesarean section</kwd><kwd>cardiovascular system</kwd><kwd>Holter electrocardiography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Volodin H.H. Perinatal medicine: problems, ways and conditions to solve them. Pediatriya = Pediatrics. 2004; 5: 18–23.</mixed-citation><mixed-citation xml:lang="en">Volodin H.H. Perinatal medicine: problems, ways and conditions to solve them. Pediatriya = Pediatrics. 2004; 5: 18–23.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Krasnopol'skii V.I., Logutova L.S., Petrukhin V.A. Place of abdominal and vaginal operative delivery in modern obstetrics. Reality and prospects. Akusherstvo i ginekologiya = Obstetrics and gynecology. 2012; 1: 4–8.</mixed-citation><mixed-citation xml:lang="en">Krasnopol'skii V.I., Logutova L.S., Petrukhin V.A. Place of abdominal and vaginal operative delivery in modern obstetrics. Reality and prospects. Akusherstvo i ginekologiya = Obstetrics and gynecology. 2012; 1: 4–8.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Sheinbakh L.N. Influence factors of hypoxia on the heart of the newborn. Meditsinskie novosti = Medical news. 2008; 2: 18–22.</mixed-citation><mixed-citation xml:lang="en">Sheinbakh L.N. Influence factors of hypoxia on the heart of the newborn. Meditsinskie novosti = Medical news. 2008; 2: 18–22.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Szymankiewicz M., Matuszczak-Wleklak M., Vidyasagar D. Retrospective diagnosis of hypoxic myocardial injury in premature newborns. J. Perinat. Med. 2006; 34 (3): 220–225.</mixed-citation><mixed-citation xml:lang="en">Szymankiewicz M., Matuszczak-Wleklak M., Vidyasagar D. Retrospective diagnosis of hypoxic myocardial injury in premature newborns. J. Perinat. Med. 2006; 34 (3): 220–225.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Banasiak K.J., Xia Y., Haddad G.G. Mechanisms underlying hypoxia-induced neonatal apoptosis. Prog. Neurobiol. 2000; 62: 215–219.</mixed-citation><mixed-citation xml:lang="en">Banasiak K.J., Xia Y., Haddad G.G. Mechanisms underlying hypoxia-induced neonatal apoptosis. Prog. Neurobiol. 2000; 62: 215–219.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hersey P., Zhang X.D. Overcoming resistance of cancer cells to apoptosis. J. Cell Physiol. 2003; 196 (1): 9–18.</mixed-citation><mixed-citation xml:lang="en">Hersey P., Zhang X.D. Overcoming resistance of cancer cells to apoptosis. J. Cell Physiol. 2003; 196 (1): 9–18.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kotlukova N.P., Simonova L.V., Zhdanova L.I. Modern views on the mechanisms of cardiovascular disease in young children. Ross. vestn. perinatol. i pediatrii = Russian bulletin of perinatology and pediatrics. 2003; 48 (3): 28–33.</mixed-citation><mixed-citation xml:lang="en">Kotlukova N.P., Simonova L.V., Zhdanova L.I. Modern views on the mechanisms of cardiovascular disease in young children. Ross. vestn. perinatol. i pediatrii = Russian bulletin of perinatology and pediatrics. 2003; 48 (3): 28–33.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kulakov V.I., Barashnev Yu.I. Novorozhdennye vysokogo riska [High-risk Newborns]. Moscow, GEOTAR-Media, 2006. 528 p.</mixed-citation><mixed-citation xml:lang="en">Kulakov V.I., Barashnev Yu.I. Novorozhdennye vysokogo riska [High-risk Newborns]. Moscow, GEOTAR-Media, 2006. 528 p.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kraeva O.A., Kovtun O.P., Kovalev V.V., Mordvintseva Yu.A., Kostousova E.V. Some aspects of the formation of functional disorders of the heart in newborn infants. Vestn. ural'skoi med. akadem. nauki = Bulletin of Ural Medical Academy of Sciences. 2009; 4 (27): 33–36.</mixed-citation><mixed-citation xml:lang="en">Kraeva O.A., Kovtun O.P., Kovalev V.V., Mordvintseva Yu.A., Kostousova E.V. Some aspects of the formation of functional disorders of the heart in newborn infants. Vestn. ural'skoi med. akadem. nauki = Bulletin of Ural Medical Academy of Sciences. 2009; 4 (27): 33–36.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Makarov L.M. Kholterovskoe monitorirovanie. 3-e izd. [Holter Monitoring, 3rd edition]. Moscow, Medpraktika-M, 2008. 456p.</mixed-citation><mixed-citation xml:lang="en">Makarov L.M. Kholterovskoe monitorirovanie. 3-e izd. [Holter Monitoring, 3rd edition]. Moscow, Medpraktika-M, 2008. 456p.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Svintsova L.I., Kovalev I.A., Murzina O.Yu., Popov S.V. Features of etiology, clinical course and treatment of tachyarrhythmias in fetuses and young children. Pediatriya = Pediatrics. 2008; 87 (1): 139–142.</mixed-citation><mixed-citation xml:lang="en">Svintsova L.I., Kovalev I.A., Murzina O.Yu., Popov S.V. Features of etiology, clinical course and treatment of tachyarrhythmias in fetuses and young children. Pediatriya = Pediatrics. 2008; 87 (1): 139–142.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Massin M.M., Maeyns K., Withofs N. Circadian rhythm of heart rate and heart rate variability. Arch. Dis. Childhood. 2000; 83: 179–182.</mixed-citation><mixed-citation xml:lang="en">Massin M.M., Maeyns K., Withofs N. Circadian rhythm of heart rate and heart rate variability. Arch. Dis. Childhood. 2000; 83: 179–182.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
