vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v19i6.2147vsp-2506Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWВопросы этиопатогенетической общности сочетанных форм локализованной склеродермии и витилигоEtiopathogenetic Similarities of Combined Forms of Localized Scleroderma and Vitiligohttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinNikolay N.

Мурашкин Николай Николаевич, доктор медицинских наук, заведующий отделением дерматологии с группой лазерной хирургии, заведующий лабораторией патологии кожи у детей отдела научных исследований в педиатрии НМИЦ здоровья детей, профессор кафедры дерматовенерологии и косметологии ЦГМА, профессор кафедры педиатрии и детской ревматологии Первого МГМУ им. И.М. Сеченова, заведующий отделом детской дерматологии НИИ педиатрии и охраны здоровья детей ЦКБ РАН

119296, Москва, Ломоносовский пр-т, д. 2, стр. 1

m_nn2001@mail.ruhttps://orcid.org/0000-0001-6884-5171СавеловаА. А.SavelovaAlena A.https://orcid.org/0000-0002-0081-0981ИвановР. А.IvanovRoman A.https://orcid.org/0000-0002-8232-8936АмбарчянЭ. Т.AmbarchianEduard T.https://orcid.org/0000-0002-6034-8231МатерикинА. И.MaterikinAlexander I.https://orcid.org/0000-0002-4107-4642ЕпишевР. В.EpishevRoman V.https://orcid.org/0000-0002-0858-8780ОпрятинЛ. А.OpryatinLeonid A.Национальный медицинский исследовательский центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Центральная государственная медицинская академия Управления делами Президента РФ; НИИ педиатрии и охраны здоровья детей ЦКБ РАНРоссияNational Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University (Sechenov University); Central State Medical Academy of Department of Presidential Affairs; Research Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”Russian FederationЦентральная государственная медицинская академия Управления делами Президента РФРоссияCentral State Medical Academy of Department of Presidential AffairsRussian FederationНациональный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian Federation202025122020196452459Copyright © Мурашкин Н.Н., Савелова А.А., Иванов Р.А., Амбарчян Э.Т., Материкин А.И., Епишев Р.В., Опрятин Л.А., 20202020Мурашкин Н.Н., Савелова А.А., Иванов Р.А., Амбарчян Э.Т., Материкин А.И., Епишев Р.В., Опрятин Л.А.Murashkin N.N., Savelova A.A., Ivanov R.A., Ambarchian E.T., Materikin A.I., Epishev R.V., Opryatin L.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/2506

Витилиго является распространенным заболеванием кожи, характеризующимся идиопатическим прогрессирующим кожным гипомеланозом. Витилиго связано с несколькими сопутствующими аутоиммунными заболеваниями, в том числе с локализованной склеродермией. В данной статье мы покажем общий механизм развития данных патологий, а также ключевой момент взаимного влияния между аутоиммунными заболеваниями на молекулярном уровне. В последнее время в дерматологической практике отмечается увеличение числа больных, страдающих сочетанными патологиями, которые характеризуются торпидным течением и отсутствием патогномоничных симптомов у пациентов детского возраста, что затрудняет диагностику и назначение адекватной терапии. Это побуждает к повышению осведомленности и информированию врачей различных специальностей о возможных сочетаниях, клинической картине и аспектах патогенеза данных состояний.

Vitiligo is a common skin disease characterized by idiopathic progressive skin hypomelanosis. Vitiligo is associated with several comorbid autoimmune diseases such as localized scleroderma. This article demonstrates the general development mechanism of these pathologies, as well as the key aspect of cross-effect between autoimmune diseases on the molecular level. Recently, dermatologists have noted the increasing number of patients suffering from combined pathologies. Such patients (in pediatrics) have torpid course of disease and no pathognomonic symptoms. That exaggerates the diagnostics and adequate therapy prescription. This leads to increased awareness among physicians of different specialties on possible combinations, clinical presentation and pathogenesis aspects of such conditions.

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The authors declare that there are no conflicts of interest present.