vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v12i6.876vsp-258Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCEЛЕЧЕНИЕ АЛЛЕРГИЧЕСКОГО РИНИТА У ДЕТЕЙ: ВЫБОР АНТИГИСТАМИННОГО ПРЕПАРАТА И НЕОБХОДИМОСТЬ ПРОВЕДЕНИЯ ДАЛЬНЕЙШИХ ИССЛЕДОВАНИЙTREATMENT OF ALLERGIC RHINITIS IN CHILDREN: SELECTION OF ANTIHISTAMINE DRUG AND NECESSITY OF FURTHER INVESTIGATIONSКарауловА. В.KaraulovA. V.

Karaulov Aleksandr Viktorovich, Doctor of Medical Science, Professor, Corresponding Member of the Russian Academy of Medical Sciences, Head of the Department of Clinical Immunology and Allergy

drkaraulov@mail.ruПервый Московский государственный медицинский университет им. И.М. СеченоваРоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation201307122013126Вопросы современной педиатрии6772Copyright © Караулов А.В., 20132013Караулов А.В.Karaulov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/258

В обзоре литературы проводится анализ результатов исследований о лечении аллергического ринита у детей с позиций доказательной медицины. Оральные и интраназальные антигистаминные препараты, наряду с интраназальными глюкокортикоидами, являются препаратами первой линии терапии аллергического ринита, хотя последние более эффективны для устранения заложенности носа. Рассматриваются применяемые в настоящее время в медицинской практике антигистаминные препараты I и II поколения. Подчеркиваются преимущества неседативных антигистаминных препаратов II поколения, в особенности т.н. активных метаболитов (фексофенадин, цетиризин, левоцетиризин, дезлоратадин). Подробно представлены данные по лоратадину и дезлоратадину как по одним из наиболее эффективных препаратов у детей с аллергическим ринитом. Обсуждаются возможные направления исследований по обеспечению эффективного контроля аллергического воспаления у детей, резистентных к лекарственным препаратам.

This literature review contains analysis of research results on treatment of allergic rhinitis in children according to the evidence-based medicine. Oral and intranasal antihistamine drugs along with intranasal steroids are the first-line drugs for treatment of allergic rhinitis, although the latter are more efficient in suppression of nasal stuffiness. First- and second-generation antihistamine agents used nowadays in medical practice are discussed in the article. The advantages of non-sedative 2d-genereation antihistamine drugs, especially so called active metabolites (fexofenadine, cetirizine, levocetirizine, desloratadine) are emphasized. The data on loratadine and desloratadine as ones of the most effective drugs in childhood allergic rhinitis are shown in detail. The possible directions for the further investigations in order to provide effective control over allergic inflammation in children resistant to medicinal agents are discussed.

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The authors declare that there are no conflicts of interest present.