vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v20i3/2272vsp-2683Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWВыбор смеси при диетотерапии детей с аллергией к белкам коровьего молокаFormula Alternatives for Nutrition Therapy of Children with Cow’s Milk Protein Allergyhttps://orcid.org/0000-0002-7571-5460НовикГ. А.NovikGennadiy A.

Новик Геннадий Айзикович, доктор медицинских наук, профессор, заведующий кафедрой педиатрии им. проф. И.М. Воронцова 

194100, Санкт-Петербург, ул. Литовская, д. 2

Saint Petersburg

ga_novik@mail.ruhttps://orcid.org/0000-0001-7035-0100ЖдановаМ. В.ZhdanovaMaria V.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0002-3942-6805ЗайцеваЮ. О.ZaitsevaYulia O.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0002-9184-1803ДемидоваА. С.DemidovaAnastasiia S.

Санкт-Петербург

Saint Petersburg

Санкт-Петербургский государственный педиатрический медицинский университетРоссияSaint Petersburg State Pediatric Medical UniversityRussian Federation202106082021203223231Copyright © Новик Г.А., Жданова М.В., Зайцева Ю.О., Демидова А.С., 20212021Новик Г.А., Жданова М.В., Зайцева Ю.О., Демидова А.С.Novik G.A., Zhdanova M.V., Zaitseva Y.O., Demidova A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/2683

Общепризнанной тактикой ведения детей с аллергией к белкам коровьего молока (АБКМ), находящихся на искусственном вскармливании, считается исключение цельного белка коровьего молока с заменой его на высокогидролизованную или аминокислотную смесь. Одним из актуальных вопросов является выбор конкретной лечебной смеси у ребенка с АБКМ. В статье представлены сведения о клинических проявлениях АБКМ, описаны принципы диетотерапии. Подробно обсуждены этапы создания адаптированной лечебной смеси. Показано, что выбор лечебной смеси для ребенка с АБКМ зависит от клинических проявлений заболевания, степени их тяжести и наличия коморбидных состояний. Современные требования к высокогидролизованным смесям сводятся к ограничениям размеров пептидов, обладающих иммунореактивными свойствами, а также указывают на необходимость получения доказательств клинической эффективности таких смесей в двойных слепых плацебо-контролируемых исследованиях.

Well-recognized tactic for the management of formula-fed children with cow’s milk protein allergy (CMPA) is exclusion of whole cow milk protein and its replacement with extensively hydrolyzed or amino acid formula. One of the most topical issue is the choice of therapeutic formula for a child with CMPA. This article presents information about the clinical manifestations of CMPA and describes the principles of nutrition therapy. All the stages of preparation of adapted therapeutic formula are discussed in detail. It has been shown that the choice of therapeutic formula for a child with CMPA depends on the disease clinical manifestations, their severity, and the presence of comorbid conditions. Current requirements for extensively hydrolyzed formula are reduced to limitations in the size of peptides with immunoreactive properties and indicate the need for evidence of the clinical efficacy of such formula in double-blind placebo-controlled studies.

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The authors declare that there are no conflicts of interest present.