vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v20i5.2309vsp-2754Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWМеханизмы формирования и возможности терапевтической коррекции стероидрезистентности у пациентов с атопическим дерматитомMechanisms of Development and Variants of Therapeutic Management of Steroid Resistance in Patients with Atopic Dermatitishttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinNikolay N.

Мурашкин Николай Николаевич - доктор медицинских наук, заведующий отделением дерматологии с группой лазерной хирургии, заведующий лабораторией патологии кожи у детей отдела научных исследований в педиатрии НМИЦ здоровья детей; профессор кафедры дерматовенерологии и косметологии ЦГМА; профессор кафедры педиатрии и детской ревматологии Первого МГМУ им. И.М. Сеченова.119296, Москва, Ломоносовский пр-т, д. 2, стр. 1.Тел.: +7 (495) 967-14-20

Moscow.

m_nn2001@mail.ruhttps://orcid.org/0000-0002-4107-4642ЕпишевР. В.EpishevRoman V.

Москва.

Moscow.

https://orcid.org/0000-0002-6034-8231МатерикинА. И.MaterikinAlexander I.

Москва.

Moscow.

https://orcid.org/0000-0002-8232-8936АмбарчянЭ. Т.AmbarchyanEduard T.

Москва.

Moscow.

https://orcid.org/0000-0002-0858-8780ОпрятинЛ. А.OpryatinLeonid A.

Москва.

Moscow.

https://orcid.org/0000-0002-0081-0981ИвановР. А.IvanovRoman A.

Москва.

Moscow.

Национальный медицинский исследовательский центр здоровья детей; Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет); Центральная государственная медицинская академияРоссияNational Medical Research Center of Children's Health; Sechenov First Moscow State Medical University (Sechenov University); Central State Medical AcademyRussian FederationНациональный медицинский исследовательский центр здоровья детейРоссияNational Medical Research Center of Children's HealthRussian FederationНИИ педиатрии и охраны здоровья детей ЦКБ РАНРоссияResearch Institute of Pediatrics and Children's Health in “Central Clinical Hospital of the Russian Academy of Sciences”Russian Federation202107112021205370375Copyright © Мурашкин Н.Н., Епишев Р.В., Материкин А.И., Амбарчян Э.Т., Опрятин Л.А., Иванов Р.А., 20212021Мурашкин Н.Н., Епишев Р.В., Материкин А.И., Амбарчян Э.Т., Опрятин Л.А., Иванов Р.А.Murashkin N.N., Epishev R.V., Materikin A.I., Ambarchyan E.T., Opryatin L.A., Ivanov R.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/2754

Кожа является естественной средой обитания сложных сообществ (экосистем) бактерий, грибков и вирусов. Микробиом этих сообществ находится в тесной взаимосвязи с геномом хозяина, а формирование экосистем происходит под воздействием как морфофизиологических и иммунологических характеристик кожи (концентрация сальных желез, содержание влаги и температура), так и факторов окружающей среды. Метагеномные исследования демонстрируют значительное разнообразие в экосистемах кожи. При этом роль комменсальных микроорганизмов в модуляции иммунного ответа кожи на различные агенты и, таким образом, связь с патогенезом кожных заболеваний уже не вызывает сомнений. На основе этих знаний разработаны новые пробиотические и противомикробные средства, используемые для наружного лечения, в т.ч. стероидрезистентные формы болезни.

Skin is the natural habitat for complex bacterial, fungal, and viral communities (ecosystems). The microbiome of such communities is always in close relationship with the host genome, and the development of these ecosystems happens under the effects of morpho-physiological and immunological characteristics of the skin (sebaceous glands concentration, humidity, and temperature) and environmental factors. Metagenomic studies have shown significant diversity in skin ecosystems. Moreover, the role of commensal microorganisms in skin immune response modulating to various agents and, thus, its correlation with skin diseases pathogenesis is no longer in doubt. New probiotic and antimicrobial agents for external treatment have been developed according to these knowledges.

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The authors declare that there are no conflicts of interest present.