vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v20i6.2355vsp-2780Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWМоделирование протективных факторов грудного молока: нутритивное программирование здоровья ребенкаBreast Milk Protective Factors Modelling: Nutritional Programming of Child’s Healthhttps://orcid.org/0000-0002-8717-2539БеляеваИ. А.BelyaevaIrina A.

Беляева Ирина Анатольевна, доктор медицинских наук, профессор РАН, профессор кафедры факультетской педиатрии педиатрического факультета РНИМУ им. Н.И. Пирогова, главный научный сотрудник НИИ педиатрии и охраны здоровья детей ЦКБ РАН, врач-неонатолог высшей квалификационной категории Морозовской детской городской клинической больницы

119333, Москва, ул. Фотиевой, д. 10, к. 1

Moscow

irinaneo@mail.ruhttps://orcid.org/0000-0002-6677-2914БомбардироваЕ. П.BombardirovaElena P.

Москва

Moscow

https://orcid.org/0000-0002-4955-0121ТуртиТ. В.TurtiTatiana V.

Москва

Moscow

ПриходькоЕ. А.PrikhodkoEvgeniia A.

Москва

Moscow

НИИ педиатрии и охраны здоровья детей ЦКБ РАН; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; Морозовская детская городская клиническая больницаРоссияResearch Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University; Morozovskaya Children’s City HospitalRussian FederationНИИ педиатрии и охраны здоровья детей ЦКБ РАНРоссияResearch Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”Russian FederationНИИ педиатрии и охраны здоровья детей ЦКБ РАН; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; НИИ организации здравоохранения и медицинского менеджментаРоссияResearch Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical ManagementRussian FederationМорозовская детская городская клиническая больницаРоссияMorozovskaya Children’s City HospitalRussian Federation202117122021206492498Copyright © Беляева И.А., Бомбардирова Е.П., Турти Т.В., Приходько Е.А., 20222022Беляева И.А., Бомбардирова Е.П., Турти Т.В., Приходько Е.А.Belyaeva I.A., Bombardirova E.P., Turti T.V., Prikhodko E.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/2780

Обзор посвящен современным возможностям моделирования уникальных свойств грудного молока при производстве детских молочных смесей. Основным направлением такого моделирования является приближение белкового состава смеси к спектру белков грудного молока, прежде всего обеспечение достаточного уровня α-лактальбумина. Этот протеин обладает многонаправленными протективными свойствами; на его основе в организме синтезируется антибактериальный и иммуномодулирующий пептидный комплекс HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells — комплекс α-лактальбумина и олеиновой кислоты). Аминокислотный состав α-лактальбумина обеспечивает мягкое нейропротекторное влияние за счет достаточного уровня триптофана. Небелковые компоненты создаваемых смесей, в т.ч. углеводные и жировые, усиливают их протективные качества и обеспечивают профилактику отсроченных нарушений здоровья. В обзоре приведены сведения об инновационном продукте детского питания, содержащем α-лактальбумин и другие биоактивные компоненты, сходные с таковыми в женском молоке.

This review covers modern possibilities of modeling breast milk unique properties to produce infant milk formulas. The main approach of such modelling is to advance the protein composition in the formula to the spectrum of breast milk proteins, primarily α-lactalbumin. This protein has multi-directional protective properties; the organism synthesizes the antibacterial and immunomodulating peptide complex HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells, complex of α-lactalbumin and oleic acid) on its basis. The amino acid composition of α-lactalbumin provides mild neuroprotective effect due to sufficient level of tryptophan. Non-protein components of the produced formulas (carbohydrate and fat included) enhance their protective qualities and ensure the prevention of delayed health disorders. This review provides information about the innovative baby food product containing ?-lactalbumin and other bioactive components like those in breast milk.

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The authors declare that there are no conflicts of interest present.