vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v20i6.2356vsp-2781Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWСтратегии научно-практического поиска: существует ли связь между формированием оси «кишечник – мозг» и характеристиками сна младенцев?Strategies for Scientific and Practicall Search: is There Any Correlation Between the Development of the Gut-Brain Axis and the Sleep Characteristics in Infants?https://orcid.org/0000-0002-8717-2539БеляеваИ. А.BelyaevaIrina A.

Беляева Ирина Анатольевна, доктор медицинских наук, профессор РАН, профессор кафедры факультетской педиатрии педиатрического факультета РНИМУ им. Н.И. Пирогова, главный научный сотрудник НИИ педиатрии и охраны здоровья детей ЦКБ РАН, врач-неонатолог высшей квалификационной категории Морозовской детской городской клинической больницы

119333, Москва, ул. Фотиевой, д. 10, к. 1

Moscow

irinaneo@mail.ruhttps://orcid.org/0000-0002-4955-0121ТуртиТ. В.TurtiTatiana V.

Москва

Moscow

https://orcid.org/0000-0002-6677-2914БомбардироваЕ. П.BombardirovaElena P.

Москва

Moscow

https://orcid.org/0000-0001-9225-8372СадчиковП. Е.SadchikovPavel E.

Москва

Moscow

НагоновА. Ю.NagonovAlexander Yu.

Москва

Moscow

НИИ педиатрии и охраны здоровья детей ЦКБ РАН; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; Морозовская детская городская клиническая больницаРоссияResearch Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University; Morozovskaya Children’s City HospitalRussian FederationНИИ педиатрии и охраны здоровья детей ЦКБ РАН; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; НИИ организации здравоохранения и медицинского менеджментаРоссияResearch Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical ManagementRussian FederationНИИ педиатрии и охраны здоровья детей ЦКБ РАНРоссияResearch Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”Russian FederationНИИ педиатрии и охраны здоровья детей ЦКБ РАН; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияResearch Institute of Pediatrics and Children’s Health in “Central Clinical Hospital of the Russian Academy of Sciences”; Pirogov Russian National Research Medical UniversityRussian Federation202117122021206499505Copyright © Беляева И.А., Турти Т.В., Бомбардирова Е.П., Садчиков П.Е., Нагонов А.Ю., 20222022Беляева И.А., Турти Т.В., Бомбардирова Е.П., Садчиков П.Е., Нагонов А.Ю.Belyaeva I.A., Turti T.V., Bombardirova E.P., Sadchikov P.E., Nagonov A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/2781

В обзоре приведен анализ современных публикаций по проблеме взаимосвязи формирования кишечной микробиоты ребенка с созреванием паттернов нейрофизиологической деятельности на примере становления возрастной структуры сна. Показана значимость этапного созревания кишечной микробиоты в свете концепции оси «головной мозг – кишечный микробиом» (brain – gut microbiom axis); описаны механизмы и медиаторы, задействованные в формировании этой оси, и обоснована ее онтогенетическая значимость. Представлены основные этапы становления функции сна у ребенка как важного компонента общего созревания психики во взаимосвязи с факторами окружающей среды и установками семьи, а также рекомендации по продолжительности периодов сна; оценка характеристик засыпания и структуры сна. Показаны прямые и обратные связи количественных и качественных параметров микробиоты с эффективностью сна. Выявлена положительная корреляция между консолидированностью сна, количеством и разнообразием видов Bacteroidetes в кишечной микробиоте, а также составом бактериальных метаболитов. Наличие указанных связей является теоретическим обоснованием для разработки методов патогенетической коррекции нарушений как микробиоты, так и сна.

The review provides the analysis of modern publications on the topic of correlation between development of intestinal microbiota and maturation of neurophysiological activity patterns (on the example of sleep age structure development). The importance of the stage maturation of intestinal microbiota in the concept of the gut-brain axis is presented. Mechanisms and mediators involved in this axis are described, and its ontogenetic significance is justified. The main stages of sleep function development in a child as an important component of the general mental health maturation in relation to environmental factors and family features are presented. Recommendations on sleep periods duration and estimation of sleep onset and sleep structure are also given. Direct and reverse correlations of quantitative and qualitative microbiota parameters with sleep efficiency are shown. Positive correlation was identified between sleep consolidation, number and diversity of Bacteroidetes species in intestinal microbiota, and composition of bacterial metabolites. The presence of such correlations is theoretical justification for further development of methods of pathogenetic therapy of both microbiota and sleep disorders. Keywords: sleep, diet, nutrition, sleeping schedule, infant, development, intestinal microbiota.

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The authors declare that there are no conflicts of interest present.