vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/pf.v19i2.2404vsp-2908Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWОтдаленное развитие и здоровье детей, зачатых с помощью вспомогательных репродуктивных технологийLong-Term Development and Health of Children Conceived by Assisted Reproductive Technologieshttps://orcid.org/0000-0002-8717-2539БеляеваИ. А.BelyaevaIrina А.

Беляева Ирина Анатольевна, доктор медицинских наук, профессор РАН, главный научный сотрудник НИИ педиатрии и охраны здоровья детей Научно-клинического Центра № 2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского, профессор кафедры факультетской педиатрии педиатрического факультета ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, врач-неонатолог высшей квалификационной категории ГБУЗ «Морозовская ДГКБ ДЗМ»

119333, Москва, ул. Фотиевой, д. 10, стр. 1,

тел.: +7 (499) 137-01-97

Moscow

irinaneo@mail.ruhttps://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Москва

Moscow

https://orcid.org/0000-0003-3987-8112БарановА. А.BaranovAlexander A.

Москва

Moscow

https://orcid.org/0000-0003-0317-2425ЭфендиеваК. Е.EfendievaKamilla Y.

Москва

Moscow

https://orcid.org/0000-0002-8540-3858КаркашадзеГ. А.KarkashadzeGeorge A.

Москва

Moscow

ДедюкинаЕ. С.DedyukinaElena S.

Тюмень

Tyumen 

https://orcid.org/0000-0002-4692-4802СеребряковаЕ. Н.SerebryakovaElena N.

Москва

Moscow

КонстантинидиТ. А.KonstantinidiTatiana A.

Москва

Moscow

https://orcid.org/0000-0003-0039-943XМолодченковА. И.MolodchenkovAlexey I.

Москва

Moscow

ГогберашвилиТ. Ю.GogberashviliTinatin Yu.

Москва

Moscow

НИИ педиатрии и охраны здоровья детей Научно-клинического Центра № 2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова; ГБУЗ «Морозовская детская городская клиническая больница ДЗМ»РоссияResearch Institute of Pediatrics and Children’s Health in Clinical Research Centre № 2 of “Russian Research Center of Surgery named after academician B.V. Petrovsky”; Pirogov Russian National Research Medical University; Morozov Children’s City HospitalRussian FederationНИИ педиатрии и охраны здоровья детей Научно-клинического Центра № 2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияResearch Institute of Pediatrics and Children’s Health in Clinical Research Centre № 2 of “Russian Research Center of Surgery named after academician B.V. Petrovsky”; Pirogov Russian National Research Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей Научно-клинического Центра № 2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»РоссияResearch Institute of Pediatrics and Children’s Health in Clinical Research Centre № 2 of “Russian Research Center of Surgery named after academician B.V. Petrovsky”Russian FederationТюменский государственный медицинский университетРоссияTyumen State Medical UniversityRussian FederationФГБОУ ВО «Южно-Уральский государственный медицинский университет»Federal State Budgetary Educational Institution of Higher Education "South-Ural State Medical University" of the Ministry of Healthcare of the Russian FederationФИЦ «Информатика и управление» РАН; ФГАОУ ВО «Российский университет дружбы народов»РоссияSIA «Technologies for systems analysis»; Peoples’ Friendship University of RussiaRussian Federation2022130520222127282Copyright © Беляева И.А., Намазова-Баранова Л.С., Баранов А.А., Эфендиева К.Е., Каркашадзе Г.А., Дедюкина Е.С., Серебрякова Е.Н., Константиниди Т.А., Молодченков А.И., Гогберашвили Т.Ю., 20222022Беляева И.А., Намазова-Баранова Л.С., Баранов А.А., Эфендиева К.Е., Каркашадзе Г.А., Дедюкина Е.С., Серебрякова Е.Н., Константиниди Т.А., Молодченков А.И., Гогберашвили Т.Ю.Belyaeva I.А., Namazova-Baranova L.S., Baranov A.A., Efendieva K.Y., Karkashadze G.A., Dedyukina E.S., Serebryakova E.N., Konstantinidi T.A., Molodchenkov A.I., Gogberashvili T.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/2908

Демографическая ситуация в России требует расширения мер по борьбе с бесплодием, в том числе с использованием вспомогательных репродуктивных технологий (ВРТ). Представлен анализ связей ВРТ с особенностями здоровья и отдаленного развития «детей из пробирки». Показан высокий риск дизонтогений после экстракорпорального оплодотворения / интрацитоплазматического введения сперматозоидов, обусловленный эпигенетическими нарушениями, в том числе нарушениями метилирования ДНК. Для полноценного развития всех детей, в т.ч. зачатых с помощью ВРТ, имеют важное значение условия жизни, воспитания и медицинского сопровождения. Представлены связи отдаленного когнитивного развития «детей из пробирки» с особенностями воспитания в семье.

The demographic situation in Russia requires escalation of measures to combat infertility including assisted reproductive technologies (ART). The analysis of correlations between ART and features of health and long-term development of “children from the tube” is presented. There is a high risk of dysontogeny after in vitro fertilization/intracytoplasmic sperm injection due to epigenetic disorders such as DNA methylation disorders. Living conditions, parenting, education, and health care are crucial for the healthy development of all children including those conceived by ART. The correlations between long-term cognitive development of “children from the tube” and the aspects of parenting in families are presented.

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The authors declare that there are no conflicts of interest present.