vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v21i3.2428vsp-2947Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL ARTICLESАссоциация вариантов генов LEP rs2167270, LEPR rs1137100, GHRL rs696217, rs27647 и NPY rs16147 с ожирением и пищевым поведением подростков: исследование «случай-контроль»Correlations of Gene Variants LEP rs2167270, LEPR rs1137100, GHRL rs696217, rs27647, and NPY rs16147 with Obesity and Adolescent Eating Behavior: Case-Control Studyhttps://orcid.org/0000-0003-2071-0969КочетоваО. В.KochetovaOlga V.

Уфа

Ufa

https://orcid.org/0000-0001-8745-9989ШангарееваЗ. А.ShangareevaZiliya A.

Шангареева Зилия Асгатовна -кандидат медицинских наук, доцент кафедры факультетской педиатрии с курсами педиатрии, неонатологии и симуляционным центром ИДПО.

450008, Уфа, ул. Ленина, 3,  тел.: +7 (3472) 35-60-88

Ufa

shangareeva2001@mail.ruhttps://orcid.org/0000-0001-8900-2480ВиктороваТ. В.ViktorovaTatyana V.

450008, Уфа, ул. Ленина, 3

Ufa

https://orcid.org/0000-0002-1695-5173КорытинаГ. Ф.KorytinaGulnaz F.

Уфа

Ufa

https://orcid.org/0000-0001-5260-2319ВикторовВ. В.ViktorovVitaliy V.

450008, Уфа, ул. Ленина, 3

Ufa

Уфимский федеральный исследовательский центр, Российская академия наукРоссияUfa Federal Research Center of the Russian Academy of SciencesRussian FederationБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian Federation202214072022213242251Copyright © Кочетова О.В., Шангареева З.А., Викторова Т.В., Корытина Г.Ф., Викторов В.В., 20222022Кочетова О.В., Шангареева З.А., Викторова Т.В., Корытина Г.Ф., Викторов В.В.Kochetova O.V., Shangareeva Z.A., Viktorova T.V., Korytina G.F., Viktorov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/2947Обоснование

Обоснование. Детское ожирение является актуальной глобальной проблемой здравоохранения. Ассоциация вариабельных участков генов лептина и его рецептора, грелина и нейропептида Y с риском развития ожирения у детей однозначно не подтверждена. Механизмы реализации этой связи посредством влияния генов на поведение детей остаются неизученными.

Цель исследования — изучить ассоциацию вариантов генов лептина, рецептора лептина, грелина и нейропептида Y с ожирением у подростков и их пищевым поведением.

Методы

Методы. В исследование включали детей в возрасте от 10 до 18 лет с экзогенно-конституциональным ожирением и нормальной массой тела. Определяли варианты генов лептина LEP rs2167270, лептинового рецептора LEPR rs1137100, грелина GHRL rs696217 и rs27647, нейропептида Y NPY rs16147. Пищевое поведение подростков оценивали с помощью психометрических опросников DEBQ (Dutch Eating Behavior Questionnaire) и TFEQ (the Three Factor Eating Questionnaire).

Результаты

Результаты. Анализ распределения вариантов генов у 150 детей с ожирением и 150 с нормальной массой тела выявил ассоциацию с ожирением варианта rs1137100 гена LEPR (р = 0,001). Варианты rs2167270 гена LEP (р = 0,015), rs696217 гена GHRL (р = 0,040) и rs16147 гена NPY (р = 0,020) ассоциировали с пищевым поведением подростков, предрасполагающим к развитию ожирения.

Заключение

Заключение. Вариант гена рецептора лептина rs1137100 ассоциирован с ожирением у подростков, а варианты rs2167270 гена лептина, rs696217 гена грелина и rs16147 гена нейропептида Y — с особенностями их пищевого поведения.

Background

Background. Childhood obesity is topical global healthcare issue. The correlations between variable regions of genes encoding leptin and its receptor, ghrelin and neuropeptide Y, and the risk of obesity development in children have not been confirmed completely. Mechanisms for implementing such correlation via the influence of genes on children’s behavior remain unexplored.

Objective

Objective. The aim of the study is to examine the correlation between leptin, leptin receptor, ghrelin and neuropeptide Y gene variants and obesity in adolescents and their eating behavior.

Methods

Methods. The study included children aged from 10 to 18 years with exogenous constitutive obesity and normal body weight. Variants in genes for leptin LEP rs2167270, leptin receptor LEPR rs1137100, ghrelin GHRL rs696217 and rs27647, neuropeptide Y NPY rs16147 were determined. Adolescents’ eating behavior was evaluated via psychometric questionnaires DEBQ (Dutch Eating Behavior Questionnaire) and TFEQ (the Three Factor Eating Questionnaire).

Results

Results. Gene variant distribution analysis in 150 obese and 150 normal weight children has revealed correlation with obesity for the variant rs1137100 of the LEPR gene (p = 0.001). Variants rs2167270 of the LEP gene (p = 0.015), rs696217 of the GHRL gene (p = 0.040), and rs16147 of the NPY gene (p = 0.020) were associated with adolescent eating behavior predisposing to obesity.

Conclusion

Conclusion. The leptin receptor gene variant rs1137100 is associated with obesity in adolescents, and the variants rs2167270 of the leptin gene, rs696217 of the ghrelin gene, and rs16147 of the neuropeptide Y gene are associated with changes in eating behavior.

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The authors declare that there are no conflicts of interest present.