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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/vsp.v21i4.2433</article-id><article-id custom-type="elpub" pub-id-type="custom">vsp-3007</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Висцеральное ожирение: терминология, измерение и связь с воспалением</article-title><trans-title-group xml:lang="en"><trans-title>Visceral Obesity: Terminology, Measurement, and Its Correlation with Inflammation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1945-3600</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарабрина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarabrina</surname><given-names>Anna A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тарабрина Анна Александровна, аспирант кафедры факультетской педиатрии с курсом детских болезней лечебного факультета</p><p>634050, Томск, ул. Московский тракт, 2</p></bio><bio xml:lang="en"><p>Tomsk</p></bio><email xlink:type="simple">Aa.tarabrina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2962-1076</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Огородова</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ogorodova</surname><given-names>Lyudmila M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Томск</p></bio><bio xml:lang="en"><p>Tomsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7130-9609</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фёдорова</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorova</surname><given-names>Olga S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Томск</p></bio><bio xml:lang="en"><p>Tomsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>04</day><month>10</month><year>2022</year></pub-date><volume>21</volume><issue>4</issue><fpage>293</fpage><lpage>297</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тарабрина А.А., Огородова Л.М., Фёдорова О.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Тарабрина А.А., Огородова Л.М., Фёдорова О.С.</copyright-holder><copyright-holder xml:lang="en">Tarabrina A.A., Ogorodova L.M., Fedorova O.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/3007">https://vsp.spr-journal.ru/jour/article/view/3007</self-uri><abstract><p>Распространенность детского ожирения в мире значительна и является большой проблемой ввиду высокого риска развития хронических неинфекционных заболеваний. В статье представлен анализ патогенетической роли висцерального ожирения, приведено описание современных методов измерения висцеральной жировой ткани, обсуждаются вопросы терминологии по теме ожирения. Суммированы современные данные о воспалении, индуцированном избыточной висцеральной жировой тканью, и роли инфламмасом в этом процессе. Полученные сведения необходимы для разработки инструментов профилактики неблагоприятных последствий ожирения у детей.</p></abstract><trans-abstract xml:lang="en"><p>The prevalence of childhood obesity in the world is significant and it is topical issue due to the high risk of chronic non-communicable diseases development. This article presents the analysis of pathogenetic role of visceral obesity, describes modern methods for measuring visceral adipose tissue, discusses major terminology on obesity. The current data on inflammation induced by excess of visceral adipose tissue and inflammasome’s role in this process are summed up. All the findings are crucial for the development of tools for prevention any obesity associated adverse effects in children.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>висцеральное ожирение</kwd><kwd>воспаление</kwd><kwd>висцеральная жировая ткань</kwd><kwd>инфламмасома</kwd></kwd-group><kwd-group xml:lang="en"><kwd>visceral obesity</kwd><kwd>inflammation</kwd><kwd>visceral adipose tissue</kwd><kwd>inflammasome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Васюкова О.В. Федеральные клинические рекомендации по диагностике и лечению ожирения у детей и подростков. — М.: Российская ассоциация эндокринологов; 2013. — С. 5–8.</mixed-citation><mixed-citation xml:lang="en">Vasyukova OV. Federal’nye klinicheskie rekomendatsii po diagnostike i lecheniyu ozhireniya u detei i podrostkov. Moscow: Russian Association of Endocrinologists; 2013. pp. 5–8. (In Russ)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Suliga E. Visceral adipose tissue in children and adolescents: A review. Nutr Res Rev. 2009;22(2):137–147. doi: https://doi.org/10.1017/S0954422409990096</mixed-citation><mixed-citation xml:lang="en">Suliga E. Visceral adipose tissue in children and adolescents: A review. Nutr Res Rev. 2009;22(2):137–147. doi: https://doi.org/10.1017/S0954422409990096</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gaines J, Vgontzas AN, Fernandez-Mendoza J, et al. Increased inflammation from childhood to adolescence predicts sleep apnea in boys: A preliminary study. Brain Behav Immun. 2017;64:259–265. doi: https://doi.org/10.1016/j.bbi.2017.04.011</mixed-citation><mixed-citation xml:lang="en">Gaines J, Vgontzas AN, Fernandez-Mendoza J, et al. Increased inflammation from childhood to adolescence predicts sleep apnea in boys: A preliminary study. Brain Behav Immun. 2017;64:259–265. doi: https://doi.org/10.1016/j.bbi.2017.04.011</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Afshin A, Forouzanfar MH, Reitsma MB, et al. Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N Engl J Med. 2017;377(1):13–27. doi: https://doi.org/10.1056/NEJMoa1614362</mixed-citation><mixed-citation xml:lang="en">Afshin A, Forouzanfar MH, Reitsma MB, et al. Health Effects of Overweight and Obesity in 195 Countries over 25 Years. N Engl J Med. 2017;377(1):13–27. doi: https://doi.org/10.1056/NEJMoa1614362</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ожирение и избыточный вес // Информационный бюллетень ВОЗ. — 09 июня 2021. Доступно по: http://www.who.int/mediacentre/factsheets/fs311/ru. Ссылка активна на 12.08.2022.</mixed-citation><mixed-citation xml:lang="en">Obesity and overweight. In: WHO Fact sheets. 09 June 2021. (In Russ). Доступно по: http://www.who.int/mediacentre/factsheets/fs311/ru. Ссылка активна на 12.08.2022.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mladovsky P, Allin S, Masseria C, et al. Health in the European Union. Trends and analysis. World Health Organization; 2009. 164 p.</mixed-citation><mixed-citation xml:lang="en">Mladovsky P, Allin S, Masseria C, et al. Health in the European Union. Trends and analysis. World Health Organization; 2009. 164 p.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ожирение у детей: клинические рекомендации. — Российская ассоциация эндокринологов; 2021. — С. 11–12.</mixed-citation><mixed-citation xml:lang="en">Ozhirenie u detei: Clinical guidelines. Russian Association of Endocrinologists; 2021. pp. 11–12. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">WHO European Childhood Obesity Surveillance Initiative (COSI): report on the fourth round of data collection, 2015–2017. Copenhagen: WHO Regional Office for Europe; 2021.</mixed-citation><mixed-citation xml:lang="en">WHO European Childhood Obesity Surveillance Initiative (COSI): report on the fourth round of data collection, 2015–2017. Copenhagen: WHO Regional Office for Europe; 2021.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Елецкая К.А., Намазова-Баранова Л.С., Кайтукова Е.В. и др. Связь массы тела и артериального давления у детей в возрасте 11 и 15 лет: ретроспективное одномоментное исследование // Педиатрическая фармакология. — 2019. — Т. 16. — № 4. — С. 211–215. — doi: https://doi.org/10.15690/pf.v16i4.2050</mixed-citation><mixed-citation xml:lang="en">Eletskaya KA, Namazova-Baranova LS, Kaytukova EV, et al. The Correlation Between Body Weight and Arterial Blood Pressure in 11 and 15 Years Old Children: Retrospective Cross-Sectional Study. Pediatric pharmacology. 2019;16(4):211–215. (In Russ). doi: https://doi.org/10.14341/2071-8713-5141</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Намазова-Баранова Л.С., Елецкая К.А., Кайтукова Е.В. и др. Оценка физического развития детей среднего и старшего школьного возраста: анализ результатов одномоментного исследования // Педиатрическая фармакология. — 2018. — Т. 15. — № 4. — С. 333–342. — doi: https://doi.org/10.15690/pf.v15i4.1948</mixed-citation><mixed-citation xml:lang="en">Namazova-Baranova LS, Yeletskaya KA, Kaytukova EV, et al. Evaluation of the Physical Development of Children of Secondary School Age: аn Analysis of the Results of a Cross-Sectional Study. Pediatric pharmacology. 2018;15(4):333–342. (In Russ). doi: https://doi.org/10.15690/pf.v15i4.1948</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Xia L, Dong F, Gong H, et al. Association between Indices of Body Composition and Abnormal Metabolic Phenotype in Normal-Weight Chinese Adults. Int J Environ Res Public Health. 2017;14(4):391. doi: https://doi.org/10.3390/ijerph14040391</mixed-citation><mixed-citation xml:lang="en">Xia L, Dong F, Gong H, et al. Association between Indices of Body Composition and Abnormal Metabolic Phenotype in Normal-Weight Chinese Adults. Int J Environ Res Public Health. 2017;14(4):391. doi: https://doi.org/10.3390/ijerph14040391</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Simoni P, Guglielmi R, Aparisi Gomez MP. Imaging of body composition in children. Quant Imaging Med Surg. 2020;10(8): 1661–1671. doi: https://doi.org/10.21037/qims.2020.04.06</mixed-citation><mixed-citation xml:lang="en">Simoni P, Guglielmi R, Aparisi Gomez MP. Imaging of body composition in children. Quant Imaging Med Surg. 2020;10(8): 1661–1671. doi: https://doi.org/10.21037/qims.2020.04.06</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Gishti O, Gaillard R, Durmus B, et al. BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children. Pediatr Res. 2015;77(5):710–718. doi: https://doi.org/10.1038/pr.2015.29</mixed-citation><mixed-citation xml:lang="en">Gishti O, Gaillard R, Durmus B, et al. BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children. Pediatr Res. 2015;77(5):710–718. doi: https://doi.org/10.1038/pr.2015.29</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tchernof A, Després JP. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013;93(1):359–404. doi: https://doi.org/10.1152/physrev.00033.2011</mixed-citation><mixed-citation xml:lang="en">Tchernof A, Després JP. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013;93(1):359–404. doi: https://doi.org/10.1152/physrev.00033.2011</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Бородкина Д.А., Груздева О.В., Квиткова Л.В., Барбараш О.Л. Можно ли назвать висцеральное ожирение ключевым фактором парадокса ожирения? // Проблемы Эндокринологии. — 2016. — Т. 62. — № 6. — С. 3–39. — doi: https://doi.org/10.14341/probl201662633-39</mixed-citation><mixed-citation xml:lang="en">Borodkina DA, Gruzdeva OV, Kvitkova LV, Barbarash OL. Is visceral obesity the cause of obesity paradox? Problems of Endocrinology. 2016;62(6):33-39. (In Russ). doi: https://doi.org/10.14341/probl201662633-39</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Borga M, West J, Bell JD, et al. Advanced body composition assessment: From body mass index to body composition profiling. J Investig Med. 2018;66(5):1–9. doi: https://doi.org/10.1136/jim-2018-000722</mixed-citation><mixed-citation xml:lang="en">Borga M, West J, Bell JD, et al. Advanced body composition assessment: From body mass index to body composition profiling. J Investig Med. 2018;66(5):1–9. doi: https://doi.org/10.1136/jim-2018-000722</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Fang H, Berg E, Cheng X, et al. How to best assess abdominal obesity. Curr Opin Clin Nutr Metab Care. 2018;21(5):360–365. doi: https://doi.org/10.1097/MCO.0000000000000485</mixed-citation><mixed-citation xml:lang="en">Fang H, Berg E, Cheng X, et al. How to best assess abdominal obesity. Curr Opin Clin Nutr Metab Care. 2018;21(5):360–365. doi: https://doi.org/10.1097/MCO.0000000000000485</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Брель Н.К., Коков А.Н., Груздева О.В. Достоинства и ограничения различных методов диагностики висцерального ожирения // Ожирение и метаболизм. — 2018. — Т. 15. — № 4. — C. 3–8. — doi: https://doi.org/10.14341/omet9510</mixed-citation><mixed-citation xml:lang="en">Brel NK, Kokov AN, Gruzdeva OV. Advantages and disadvantages of different methods for diagnosis of visceral obesity. Obesity and metabolism. 2018;15(4):3–8. (In Russ). doi: https://doi.org/10.14341/omet9510</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Сусляева Н.М. Возможности лучевых методов исследования в диагностике висцерального ожирения // Бюллетень сибирской медицины. — 2010. — Т. 9. — № 5. — C. 121–128. — doi: https://doi.org/10.20538/1682-0363-2010-5-121-128</mixed-citation><mixed-citation xml:lang="en">Suslyaeva NM. Possibility radiological methods in diagnostics of visceral adiposity. Bulletin of Siberian Medicine. 2010;9(5):121–128. (In Russ). doi: https://doi.org/10.20538/1682-0363-2010-5-121-128</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Messina C, Albano D, Gitto S, et al. Body composition with dual energy X-ray absorptiometry: from basics to new tools. Quant Imaging Med Surg. 2020;10(8):1687–1698. doi: https://doi.org/10.21037/qims.2020.03.02</mixed-citation><mixed-citation xml:lang="en">Messina C, Albano D, Gitto S, et al. Body composition with dual energy X-ray absorptiometry: from basics to new tools. Quant Imaging Med Surg. 2020;10(8):1687–1698. doi: https://doi.org/10.21037/qims.2020.03.02</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Подчиненова Д.В. Оптимизация стратегии профилактики метаболического синдрома в педиатрической практике: дис. … канд. мед. наук. — Томск; 2019. — 153 с.</mixed-citation><mixed-citation xml:lang="en">Podchinenova D.V. Optimizatsiya strategii profilaktiki metabolicheskogo sindroma v pediatricheskoi praktike. [dissertation]. Tomsk; 2019. 153 p. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Патент № 2734336 Российская Федерация, МПК A61В 5/00 (2006.01), А61В 5/053 (2006.01). Способ ранней неинвазивной диагностики метаболических нарушений у детей и подростков: № 2020112469: заявл. 27.03.2020: опубл. 15.10.2020 / Кобякова О.С., Подчиненова Д.В., Самойлова Ю.Г. и др. — 8 с.</mixed-citation><mixed-citation xml:lang="en">Patent № 2734336 Russian Federation, IPC А61В 5/00 (2006.01), А61В 5/053 (2006.01). Method for Early Non-Invasive Diagnosis of Metabolic Disorders in Children and Adolescents: № 2020112469: declare 27.03.2020: publ. 15.10.2020. Kobyakova OS, Podchinenova DV, Samojlova YuG, et al. 8 p. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Soileau L, Bautista D, Johnson C, et al. Automated anthropometric phenotyping with novel Kinect-based three-dimensional imaging method: comparison with a reference laser imaging system. Eur J Clin Nutr. 2016;70(4):475–481. doi: https://doi.org/10.1038/ejcn.2015.132</mixed-citation><mixed-citation xml:lang="en">Soileau L, Bautista D, Johnson C, et al. Automated anthropometric phenotyping with novel Kinect-based three-dimensional imaging method: comparison with a reference laser imaging system. Eur J Clin Nutr. 2016;70(4):475–481. doi: https://doi.org/10.1038/ejcn.2015.132</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Чумакова Г.А., Веселовская Н.Г. Методы оценки висцерального ожирения в клинической практике // Российский кардиологический журнал. — 2016. — № 4. — C. 89–96. — doi: https://doi.org/10.15829/1560-4071-2016-4-89-96</mixed-citation><mixed-citation xml:lang="en">Chumakova GA, Veselovskaya NG. Methods of visceral obesity assessment in clinical practice. Russian Journal of Cardiology. 2016;(4):89–96. (In Russ). doi: https://doi.org/10.15829/1560-4071-2016-4-89-96</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ly KV, Armstrong T, Yeh J, et al. Free-breathing Magnetic Resonance Imaging Assessment of Body Composition in Healthy and Overweight Children: An Observational Study. J Pediatr Gastroenterol Nutr. 2019;68(6):782–787. doi: https://doi.org/10.1097/MPG.0000000000002309</mixed-citation><mixed-citation xml:lang="en">Ly KV, Armstrong T, Yeh J, et al. Free-breathing Magnetic Resonance Imaging Assessment of Body Composition in Healthy and Overweight Children: An Observational Study. J Pediatr Gastroenterol Nutr. 2019;68(6):782–787. doi: https://doi.org/10.1097/MPG.0000000000002309</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина О.М., Купрейшвили Л.В., Фомин В.В. Композиционный состав тела и его роль в развитии метаболических нарушений и сердечно-сосудистых заболеваний // Кардиоваскулярная терапия и профилактика. — 2017. — Т. 16. — № 5. — С. 81–85. — doi: https://doi.org/10.15829/1728-8800-2017-5-81-85</mixed-citation><mixed-citation xml:lang="en">Drapkina OM, Kupreyshvili LV, Fomin VV. Body composition and its role in development of metabolic disorders and cardiovascular diseases. Cardiovascular Therapy and Prevention. 2017;16(5):81–85. (In Russ). doi: https://doi.org/10.15829/1728-8800-2017-5-81-85</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Cheung AS, de Rooy C, Hoermann R, et al. Correlation of visceral adipose tissue measured by Lunar Prodigy dual X-ray absorptiometry with MRI and CT in older men. Int J Obes (Lond). 2016;40(8): 1325–1328. doi: https://doi.org/10.1038/ijo.2016.50</mixed-citation><mixed-citation xml:lang="en">Cheung AS, de Rooy C, Hoermann R, et al. Correlation of visceral adipose tissue measured by Lunar Prodigy dual X-ray absorptiometry with MRI and CT in older men. Int J Obes (Lond). 2016;40(8): 1325–1328. doi: https://doi.org/10.1038/ijo.2016.50</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Bazzocchi A, Filonzi G, Ponti F, et al. Ultrasound: Which role in body composition? Eur J Radiol. 2016;85(8):1469–1480. doi: https://doi.org/10.1016/j.ejrad.2016.04.005</mixed-citation><mixed-citation xml:lang="en">Bazzocchi A, Filonzi G, Ponti F, et al. Ultrasound: Which role in body composition? Eur J Radiol. 2016;85(8):1469–1480. doi: https://doi.org/10.1016/j.ejrad.2016.04.005</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Миклишанская С.В., Золозова Е.А., Орловский А.А. и др. Обоснование необходимости создания новой классификации ожирения // Лечащий Врач. — 2021. — № 7. — С. 58–62. — doi: https://doi.org/10.51793/OS.2021.24.7.011</mixed-citation><mixed-citation xml:lang="en">Miklishanskaya SV, Zolozova EA, Orlovsky AA, et al. Justification of the need to create a new classification of obesity. Lechaschi Vrach. 2021;(7):58–62. (In Russ). doi: https://doi.org/10.51793/OS.2021.24.7.011</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kyle UG, Bosaeus I, De Lorenzo AD, et al. Bioelectrical impedance analysis-part I: review of principles and methods. Clin Nutr. 2004;23(5):1226–1243. doi: https://doi.org/10.1016/j.clnu.2004.06.004</mixed-citation><mixed-citation xml:lang="en">Kyle UG, Bosaeus I, De Lorenzo AD, et al. Bioelectrical impedance analysis-part I: review of principles and methods. Clin Nutr. 2004;23(5):1226–1243. doi: https://doi.org/10.1016/j.clnu.2004.06.004</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Лист результатов INBODY: руководство для профессионалов. Доступно по: https://inbody-ru.ru/u/www/files/Руководство%20для%20профессионалов.pdf. Ссылка активна на 12.08.2022.</mixed-citation><mixed-citation xml:lang="en">List rezul’tatov INBODY: Guide for professionals. (In Russ). Доступно по: https://inbody-ru.ru/u/www/files/Руководство%20для%20профессионалов.pdf. Ссылка активна на 12.08.2022.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Zamrazilova H, Hlavaty P, Dusatkova L, et al. A new simple method for estimating trunk and visceral fat by bioelectrical impedance: comparison with magnetic resonance imaging and dual X-ray absorptiometry in Czech adolescents. Cas Lek Cesk. 2010;149(9):417–422.</mixed-citation><mixed-citation xml:lang="en">Zamrazilova H, Hlavaty P, Dusatkova L, et al. A new simple method for estimating trunk and visceral fat by bioelectrical impedance: comparison with magnetic resonance imaging and dual X-ray absorptiometry in Czech adolescents. Cas Lek Cesk. 2010;149(9):417–422.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Christaki EV, Pervanidou P, Papassotiriou I, et al. Stress, Inflammation and Metabolic Biomarkers Are Associated with Body Composition Measures in Lean, Overweight, and Obese Children and Adolescents. Children (Basel). 2022;9(2):291. doi: https://doi.org/10.3390/children9020291</mixed-citation><mixed-citation xml:lang="en">Christaki EV, Pervanidou P, Papassotiriou I, et al. Stress, Inflammation and Metabolic Biomarkers Are Associated with Body Composition Measures in Lean, Overweight, and Obese Children and Adolescents. Children (Basel). 2022;9(2):291. doi: https://doi.org/10.3390/children9020291</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatt SP, Guleria R, Kabra SK. Metabolic alterations and systemic inflammation in overweight/obese children with obstructive sleep apnea. PLoS One. 2021;16(6):e0252353. doi: https://doi.org/10.1371/journal.pone.0252353</mixed-citation><mixed-citation xml:lang="en">Bhatt SP, Guleria R, Kabra SK. Metabolic alterations and systemic inflammation in overweight/obese children with obstructive sleep apnea. PLoS One. 2021;16(6):e0252353. doi: https://doi.org/10.1371/journal.pone.0252353</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Aparecida Silveira E, Vaseghi G, de Carvalho Santos AS, et al. Visceral Obesity and Its Shared Role in Cancer and Cardiovascular Disease: A Scoping Review of the Pathophysiology and Pharmacological Treatments. Int J Mol Sci. 2020;21(23):9042. doi: https://doi.org/10.3390/ijms21239042</mixed-citation><mixed-citation xml:lang="en">Aparecida Silveira E, Vaseghi G, de Carvalho Santos AS, et al. Visceral Obesity and Its Shared Role in Cancer and Cardiovascular Disease: A Scoping Review of the Pathophysiology and Pharmacological Treatments. Int J Mol Sci. 2020;21(23):9042. doi: https://doi.org/10.3390/ijms21239042</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Nier A, Brandt A, Baumann A, et al. Metabolic Abnormalities in Normal Weight Children Are Associated with Increased Visceral Fat Accumulation, Elevated Plasma Endotoxin Levels and a Higher Monosaccharide Intake. Nutrients. 2019;11(3):652. doi: https://doi.org/10.3390/nu11030652</mixed-citation><mixed-citation xml:lang="en">Nier A, Brandt A, Baumann A, et al. Metabolic Abnormalities in Normal Weight Children Are Associated with Increased Visceral Fat Accumulation, Elevated Plasma Endotoxin Levels and a Higher Monosaccharide Intake. Nutrients. 2019;11(3):652. doi: https://doi.org/10.3390/nu11030652</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Cota BC, Priore SE, Ribeiro SAV, et al. Cardiometabolic risk in adolescents with normal weight obesity. Eur J Clin Nutr. 2022;76(6):863–870. doi: https://doi.org/10.1038/s41430-021-01037-7</mixed-citation><mixed-citation xml:lang="en">Cota BC, Priore SE, Ribeiro SAV, et al. Cardiometabolic risk in adolescents with normal weight obesity. Eur J Clin Nutr. 2022;76(6):863–870. doi: https://doi.org/10.1038/s41430-021-01037-7</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Karczewski J, Śledzińska E, Baturo A, et al. Obesity and inflammation. Eur Cytokine Netw. 2018;29(3):83–94. doi: https://doi.org/10.1684/ecn.2018.0415</mixed-citation><mixed-citation xml:lang="en">Karczewski J, Śledzińska E, Baturo A, et al. Obesity and inflammation. Eur Cytokine Netw. 2018;29(3):83–94. doi: https://doi.org/10.1684/ecn.2018.0415</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Schipper HS, Nuboer R, Prop S, et al. Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes. Diabetologia. 2012;55(10):2800–2810. doi: https://doi.org/10.1007/s00125-012-2641-y</mixed-citation><mixed-citation xml:lang="en">Schipper HS, Nuboer R, Prop S, et al. Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes. Diabetologia. 2012;55(10):2800–2810. doi: https://doi.org/10.1007/s00125-012-2641-y</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Longo M, Zatterale F, Naderi J, et al. Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. Int J Mol Sci. 2019;20(9):2358. doi: https://doi.org/10.3390/ijms20092358</mixed-citation><mixed-citation xml:lang="en">Longo M, Zatterale F, Naderi J, et al. Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications. Int J Mol Sci. 2019;20(9):2358. doi: https://doi.org/10.3390/ijms20092358</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Corona-Meraz F, Anda JR, Madrigal-Ruiz P, et al. Adipose Tissue in Health and Disease. In: Obesity. Cakmur H, ed. London: IntechOpen; 2020. doi: https://doi.org/10.5772/intechopen.90559 Available online: https://www.intechopen.com/chapters/70627. Accessed on August 12, 2022.</mixed-citation><mixed-citation xml:lang="en">Corona-Meraz F, Anda JR, Madrigal-Ruiz P, et al. Adipose Tissue in Health and Disease. In: Obesity. Cakmur H, ed. London: IntechOpen; 2020. doi: https://doi.org/10.5772/intechopen.90559 Available online: https://www.intechopen.com/chapters/70627. Accessed on August 12, 2022.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Fleming CA, O’Connell EP, Kavanagh RG, et al. Body Composition, Inflammation, and 5-Year Outcomes in Colon Cancer. JAMA Netw Open. 2021;4(8):e2115274. doi: https://doi.org/10.1001/jamanetworkopen.2021.15274</mixed-citation><mixed-citation xml:lang="en">Fleming CA, O’Connell EP, Kavanagh RG, et al. Body Composition, Inflammation, and 5-Year Outcomes in Colon Cancer. JAMA Netw Open. 2021;4(8):e2115274. doi: https://doi.org/10.1001/jamanetworkopen.2021.15274</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Engin A. The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation. Adv Exp Med Biol. 2017;960:221–245. doi: https://doi.org/10.1007/978-3-319-48382-5_9</mixed-citation><mixed-citation xml:lang="en">Engin A. The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation. Adv Exp Med Biol. 2017;960:221–245. doi: https://doi.org/10.1007/978-3-319-48382-5_9</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Delaney KZ, Vanstone CA, Weiler HA, Santosa S. Regional adiposity and markers of inflammation in pre-school age children. Sci Rep. 2018;8(1):15204. doi: https://doi.org/10.1038/s41598-018-33054-1</mixed-citation><mixed-citation xml:lang="en">Delaney KZ, Vanstone CA, Weiler HA, Santosa S. Regional adiposity and markers of inflammation in pre-school age children. Sci Rep. 2018;8(1):15204. doi: https://doi.org/10.1038/s41598-018-33054-1</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Mujkić R, Šnajder Mujkić D, Ilić I, et al. Early Childhood Fat Tissue Changes-Adipocyte Morphometry, Collagen Deposition, and Expression of CD163+ Cells in Subcutaneous and Visceral Adipose Tissue of Male Children. Int J Environ Res Public Health. 2021;18(7):3627. doi: https://doi.org/10.3390/ijerph18073627</mixed-citation><mixed-citation xml:lang="en">Mujkić R, Šnajder Mujkić D, Ilić I, et al. Early Childhood Fat Tissue Changes-Adipocyte Morphometry, Collagen Deposition, and Expression of CD163+ Cells in Subcutaneous and Visceral Adipose Tissue of Male Children. Int J Environ Res Public Health. 2021;18(7):3627. doi: https://doi.org/10.3390/ijerph18073627</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Fang Z, Pyne S, Pyne NJ. Ceramide and sphingosine 1-phosphate in adipose dysfunction. Prog Lipid Res. 2019;74:145–159. doi: https://doi.org/10.1016/j.plipres.2019.04.001</mixed-citation><mixed-citation xml:lang="en">Fang Z, Pyne S, Pyne NJ. Ceramide and sphingosine 1-phosphate in adipose dysfunction. Prog Lipid Res. 2019;74:145–159. doi: https://doi.org/10.1016/j.plipres.2019.04.001</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Engin AB. Adipocyte-Macrophage Cross-Talk in Obesity. Adv Exp Med Biol. 2017;960:327–343. doi: https://doi.org/10.1007/978-3-319-48382-5_14</mixed-citation><mixed-citation xml:lang="en">Engin AB. Adipocyte-Macrophage Cross-Talk in Obesity. Adv Exp Med Biol. 2017;960:327–343. doi: https://doi.org/10.1007/978-3-319-48382-5_14</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Rheinheimer J, de Souza BM, Cardoso NS, et al. Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review. Metabolism. 2017;74:1–9. doi: https://doi.org/10.1016/j.metabol.2017.06.002</mixed-citation><mixed-citation xml:lang="en">Rheinheimer J, de Souza BM, Cardoso NS, et al. Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review. Metabolism. 2017;74:1–9. doi: https://doi.org/10.1016/j.metabol.2017.06.002</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Wu KK, Cheung SW, Cheng KK. NLRP3 Inflammasome Activation in Adipose Tissues and Its Implications on Metabolic Diseases. Int J Mol Sci. 2020;21(11):4184. doi: https://doi.org/10.3390/ijms21114184</mixed-citation><mixed-citation xml:lang="en">Wu KK, Cheung SW, Cheng KK. NLRP3 Inflammasome Activation in Adipose Tissues and Its Implications on Metabolic Diseases. Int J Mol Sci. 2020;21(11):4184. doi: https://doi.org/10.3390/ijms21114184</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Crudele L, Piccinin E, Moschetta A. Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis. Nutrients. 2021;13(6):2101. doi: https://doi.org/10.3390/nu13062101</mixed-citation><mixed-citation xml:lang="en">Crudele L, Piccinin E, Moschetta A. Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis. Nutrients. 2021;13(6):2101. doi: https://doi.org/10.3390/nu13062101</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Bonan N, DeCicco-Skinner K. Obesity as a Promoter of Cancer Development and Progression. In: Obesity. Cakmur H, ed. London: IntechOpen; 2018. doi: https://doi.org/10.5772/intechopen.80516 Available online: https://www.intechopen.com/chapters/63165. Accessed on August 12, 2022.</mixed-citation><mixed-citation xml:lang="en">Bonan N, DeCicco-Skinner K. Obesity as a Promoter of Cancer Development and Progression. In: Obesity. Cakmur H, ed. London: IntechOpen; 2018. doi: https://doi.org/10.5772/intechopen.80516 Available online: https://www.intechopen.com/chapters/63165. Accessed on August 12, 2022.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Chang HH, Eibl G. Obesity-Induced Adipose Tissue Inflammation as a Strong Promotional Factor for Pancreatic Ductal Adenocarcinoma. Cells. 2019;8(7):673. doi: https://doi.org/10.3390/cells8070673</mixed-citation><mixed-citation xml:lang="en">Chang HH, Eibl G. Obesity-Induced Adipose Tissue Inflammation as a Strong Promotional Factor for Pancreatic Ductal Adenocarcinoma. Cells. 2019;8(7):673. doi: https://doi.org/10.3390/cells8070673</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Calcaterra V, Croce S, Vinci F, et al. Th17 and Treg Balance in Children with Obesity and Metabolically Altered Status. Front Pediatr. 2020;8:591012. 2020;8:591012. doi: https://doi.org/10.3389/fped.2020.591012</mixed-citation><mixed-citation xml:lang="en">Calcaterra V, Croce S, Vinci F, et al. Th17 and Treg Balance in Children with Obesity and Metabolically Altered Status. Front Pediatr. 2020;8:591012. 2020;8:591012. doi: https://doi.org/10.3389/fped.2020.591012</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez-Sanchez ME, Hiriart M, Alvarez-Buylla ER. The CD4+ T cell regulatory network mediates inflammatory responses during acute hyperinsulinemia: a simulation study. BMC Syst Biol. 2017;11(1):64. doi: https://doi.org/10.1186/s12918-017-0436-y</mixed-citation><mixed-citation xml:lang="en">Martinez-Sanchez ME, Hiriart M, Alvarez-Buylla ER. The CD4+ T cell regulatory network mediates inflammatory responses during acute hyperinsulinemia: a simulation study. BMC Syst Biol. 2017;11(1):64. doi: https://doi.org/10.1186/s12918-017-0436-y</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Tao L, Liu H, Gong Y. Role and mechanism of the Th17/ Treg cell balance in the development and progression of insulin resistance. Mol Cell Biochem. 2019;459(1-2):183–188. doi: https://doi.org/10.1007/s11010-019-03561-4</mixed-citation><mixed-citation xml:lang="en">Tao L, Liu H, Gong Y. Role and mechanism of the Th17/ Treg cell balance in the development and progression of insulin resistance. Mol Cell Biochem. 2019;459(1-2):183–188. doi: https://doi.org/10.1007/s11010-019-03561-4</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Endo Y, Yokote K, Nakayama T. The obesity-related pathology and Th17 cells. Cell Mol Life Sci. 2017;74(7):1231–1245. doi: https://doi.org/10.1007/s00018-016-2399-3</mixed-citation><mixed-citation xml:lang="en">Endo Y, Yokote K, Nakayama T. The obesity-related pathology and Th17 cells. Cell Mol Life Sci. 2017;74(7):1231–1245. doi: https://doi.org/10.1007/s00018-016-2399-3</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
