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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/vsp.v12i4.728</article-id><article-id custom-type="elpub" pub-id-type="custom">vsp-302</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>КЛИНИЧЕСКОЕ ПРИМЕНЕНИЕ ПИРИТИНОЛА В НЕЙРОПЕДИАТРИИ</article-title><trans-title-group xml:lang="en"><trans-title>PYRITINOL USAGE IN PEDIATRIC NEUROLOGY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заваденко</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zavadenko</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="en"><p>Zavadenko Nikolai Nikolaevich, PhD, professor, Head of the Department of Neurology, Neurosurgery and Clinical Genetics of Pediatric Faculty</p></bio><email xlink:type="simple">zavadenko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нестеровский</surname><given-names>Ю. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Nesterovskii</surname><given-names>Yu. E.</given-names></name></name-alternatives><email xlink:type="simple">zavadenko@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlova</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">zavadenko@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва,</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I. Pirogov Russian National Research Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I. Pirogov Russian National Research Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>12</day><month>07</month><year>2013</year></pub-date><volume>12</volume><issue>4</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>32</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Заваденко Н.Н., Нестеровский Ю.Е., Козлова Е.В., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Заваденко Н.Н., Нестеровский Ю.Е., Козлова Е.В.</copyright-holder><copyright-holder xml:lang="en">Zavadenko N.N., Nesterovskii Y.E., Kozlova E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/302">https://vsp.spr-journal.ru/jour/article/view/302</self-uri><abstract><p>Лечение нарушений развития, коррекция трудностей обучения и проблем поведения у детей должны быть своевременными, носить комплексный характер и включать фармакотерапию препаратами ноотропного ряда. В обзоре представлены результаты исследований последних лет, подтверждающие положительные эффекты фармакотерапии пиритинолом у детей с перинатальным поражением центральной нервной системы и его последствиями, задержкой психомоторного и речевого развития, дислексией, синдромом дефицита внимания и гиперактивности, когнитивным нарушением и трудностями обучения (в т. ч. при эпилепсии, хронических тиках и синдроме Туретта). Способность пиритинола оптимизировать метаболические процессы в центральной нервной системе находит применение при лечении синдрома вегетативной дисфункции у детей и подростков, особенно в сочетании с астеническими проявлениями, а также в комплексной терапии головной боли напряжения и мигрени. Подтверждено положительное действие препарата в лечении когнитивных нарушений при эпилепсии у детей и подростков, которым назначение пиритинола производилось без изменения базовой терапии антиконвульсантами и не сопровождалось утяжелением приступов и выраженности эпилептиформной активности на электроэнцефалограмме. Выраженное ноотропное действие пиритинола, включающее нейрометаболические, нейропротекторные, нейродинамические и другие механизмы, в сочетании с безопасностью применения и редкостью побочных явлений, определяют возможности его широкого использования в нейропедиатрической практике.</p></abstract><trans-abstract xml:lang="en"><p>Treatment of developmental disorders, correction of learning disabilities and behavioral problems in children should be prompt, complex and include pharmacotherapy with nootropic agents. The results of recent studies shown in this review proved effectiveness of pharmacotherapy with pyritinol in children with perinatal injury of central nervous system and its consequences, psychomotor and speech development delay, dyslexia, attention deficit/hyperactivity disorder, cognitive disorders and learning disabilities (including manifestations of epilepsy, chronic tic disorders and Tourette syndrome). Due to its ability to optimize metabolic processes in central nervous system, pyritinol is used in treatment of vegetative dysfunction in children and adolescents, especially associated with asthenical manifestations, as well as in complex therapy of exertion headache and migraine. The drug is effective in treatment of cognitive disorders in children and adolescents with epilepsy, pyritinol was administered without changing of the basic anticonvulsive therapy and no deterioration (increase of severity of seizures or intensity of epileptiform activity on electroencephalogramms) was observed. Significant nootropic effect of pyritinol, including neurometabolic, neuroprotective, neurodynamic and other mechanisms, in association with safety and rare side effects of this drug determines its wide usage in pediatric neurology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>нарушения развития</kwd><kwd>трудности обучения</kwd><kwd>ноотропные препараты</kwd><kwd>пиритинол</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>developmental disorders</kwd><kwd>learning disabilities</kwd><kwd>nootropic agents</kwd><kwd>pyritinol</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nootropy v kognitivnoi nevrologii detskogo vozrasta. Pos. dlya vrachei [Nootropics in Cognitive Neurology Research in Children. Guideline for Doctors]. 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