vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v21i5.2449vsp-3031Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWИнновации в терапевтической коррекции микробиома кожи при атопическом дерматите в детском возрастеInnovations in Therapeutic Improvement of the Cutaneous Microbiome in Children with Atopic Dermatitishttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinNikolay N.

Мурашкин Николай Николаевич - доктор медицинских наук, заведующий отделением дерматологии с группой лазерной хирургии, заведующий лабораторией патологии кожи у детей отдела научных исследований в педиатрии НМИЦ здоровья детей, профессор кафедры дерматовенерологии и косметологии ЦГМА, профессор кафедры педиатрии и детской ревматологии ФГАОУ ВО Первый МГМУ им. И.М. Сеченова (Сеченовский Университет).

119296, Москва, Ломоносовский пр-т, д. 2, стр. 1,  тел.: +7 (495) 967-14-20

Moscow

m_nn2001@mail.ruhttps://orcid.org/0000-0002-4107-4642ЕпишевР. В.EpishevRoman V.

Москва

Moscow

https://orcid.org/0000-0002-0081-0981ИвановР. А.IvanovRoman A.

Москва

Moscow

https://orcid.org/0000-0002-6034-8231МатерикинА. И.MaterikinAlexander I.

Москва

Moscow

https://orcid.org/0000-0002-0858-8780ОпрятинЛ. А.OpryatinLeonid A.

Москва

Moscow

https://orcid.org/0000-0001-6884-5171СавеловаА. А.SavelovaAlena A.

Москва

Moscow

https://orcid.org/0000-0002-2922-3924НежведиловаР. Ю.NezhvedilovaRoza Y.

Москва

Moscow

https://orcid.org/0000-0002-8232-8936АмбарчянЭ. Т.AmbarchianRoza T.

Москва

Moscow

https://orcid.org/0000-0001-9777-0156ФедоровД. В.FedorovDmitri V.

Москва

Moscow

https://orcid.org/0000-0003-4297-4631РусаковаЛ. Л.RusakovaLyudmila L.

Москва

Moscow

НМИЦ здоровья детей; Первый МГМУ им. И.М. Сеченова (Сеченовский Университет); ЦГМА Управления делами Президента РФРоссияNational Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University; Central State Medical Academy of Department of Presidential AffairsRussian FederationНМИЦ здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ РНЦХ им. акад. Б.В. ПетровскогоРоссияPediatrics and Child Health Research Institute in Petrovsky National Research Centre of SurgeryRussian Federation202207112022215352361Copyright © Мурашкин Н.Н., Епишев Р.В., Иванов Р.А., Материкин А.И., Опрятин Л.А., Савелова А.А., Нежведилова Р.Ю., Амбарчян Э.Т., Федоров Д.В., Русакова Л.Л., 20222022Мурашкин Н.Н., Епишев Р.В., Иванов Р.А., Материкин А.И., Опрятин Л.А., Савелова А.А., Нежведилова Р.Ю., Амбарчян Э.Т., Федоров Д.В., Русакова Л.Л.Murashkin N.N., Epishev R.V., Ivanov R.A., Materikin A.I., Opryatin L.A., Savelova A.A., Nezhvedilova R.Y., Ambarchian R.T., Fedorov D.V., Rusakova L.L.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3031

Биопленка является доминирующей формой организации микробиоты кожи, способствующей адгезии и сохранению микроорганизмов в кожном микроокружении, что необходимо для обеспечения функции эпидермального барьера и местной иммуномодуляции. Во время обострения атопического дерматита основным колонизатором участков пораженной кожи становятся Staphylococcus aureus, также в основном образующие биопленку. Рост S. aureus и разрастание биопленки за счет других микробных комменсалов на коже пациентов с атопическим дерматитом ведет к хронической продукции провоспалительных цитокинов и в последующем к нарушению состава микробиома здоровой кожи. Влияние микробной биопленки кожи человека на его здоровье делает микробиоту кожи привлекательной мишенью для терапевтического воздействия при различных кожных заболеваниях.

Biofilm is the dominant form of skin microbiota organization that provides adhesion and preservation of microorganisms in the skin micro-environment. It is necessary to ensure epidermal barrier function and local immunomodulation. Staphylococcus aureus becomes the major colonizer of skin lesions in case of atopic dermatitis exacerbation, and it also can form the biofilms. S. aureus growth and biofilm formation due to other microbial commensals on the skin of patients with atopic dermatitis leads to chronic output of pro-inflammatory cytokines and later to abnormalities in healthy skin microbiome. The role of microbial biofilm in human’s health makes the skin microbiota an attractive target for therapeutic intervention in various skin diseases.

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The authors declare that there are no conflicts of interest present.