vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v21i5.2457vsp-3033Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWНаучно-практические инновации в технологии восстановления барьерных свойств кожи при атопическом дерматите у детейScientific and Practical Innovations in Restoring Skin Barrier Properties in Children with Atopic Dermatitishttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinNikolay N.

Мурашкин Николай Николаевич - доктор медицинских наук, заведующий отделением дерматологии с группой лазерной хирургии, заведующий лабораторией патологии кожи у детей отдела научных исследований в педиатрии НМИЦ здоровья детей, профессор кафедры дерматовенерологии и косметологии ЦГМА, профессор кафедры педиатрии и детской ревматологии ФГАОУ ВО Первый МГМУ им. И.М. Сеченова (Сеченовский Университет).

119296, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-08-89

Moscow

m_nn2001@mail.ruhttps://orcid.org/0000-0002-2922-3924НежведиловаР. Ю.NezhvedilovaRoza Y.

Москва

Moscow

https://orcid.org/0000-0001-9777-0156ФедоровД. В.FedorovDmitri V.

Москва

Moscow

https://orcid.org/0000-0002-4107-4642ЕпишевР. В.EpishevRoman V.

Москва

Moscow

https://orcid.org/0000-0002-0081-0981ИвановР. А.IvanovRoman A.

Москва

Moscow

https://orcid.org/0000-0002-6034-8231МатерикинА. И.MaterikinAlexander I.

Москва

Moscow

https://orcid.org/0000-0002-0858-8780ОпрятинЛ. А.OpryatinLeonid A.

Москва

Moscow

https://orcid.org/0000-0001-6884-5171СавеловаА. А.SavelovaAlena A.

Москва

Moscow

https://orcid.org/0000-0003-4297-4631РусаковаЛ. Л.RusakovaLyudmila L.

Москва

Moscow

НМИЦ здоровья детей; Первый МГМУ им. И.М. Сеченова (Сеченовский Университет); ЦГМА Управления делами Президента РФРоссияNational Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University; Central State Medical Academy of Department of Presidential AffairsRussian FederationНМИЦ здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian Federation202208112022215378382Copyright © Мурашкин Н.Н., Нежведилова Р.Ю., Федоров Д.В., Епишев Р.В., Иванов Р.А., Материкин А.И., Опрятин Л.А., Савелова А.А., Русакова Л.Л., 20222022Мурашкин Н.Н., Нежведилова Р.Ю., Федоров Д.В., Епишев Р.В., Иванов Р.А., Материкин А.И., Опрятин Л.А., Савелова А.А., Русакова Л.Л.Murashkin N.N., Nezhvedilova R.Y., Fedorov D.V., Epishev R.V., Ivanov R.A., Materikin A.I., Opryatin L.A., Savelova A.A., Rusakova L.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3033

Атопический дерматит (АтД) — многофакторное воспалительное заболевание кожи, патогенетическую основу которого составляют дисфункция эпидермального барьера, дисрегуляция иммунной системы, а также уменьшение разнообразия микробиоты кожи, возникающие на фоне генетической предрасположенности к развитию болезни. Учитывая эти факторы, кожный покров больных АтД требует постоянного ухода и использования средств, обладающих активными регенераторными свойствами. Включение в состав современных эмолентов противовоспалительных компонентов — сульфата цинка и сукральфата — необходимо для восстановления микробиома и иммунных механизмов контроля состояния кожи. В статье представлены данные о патогенетической целесообразности применения и клинической эффективности при АтД эмолентов, содержащих противовоспалительные соединения.

Atopic dermatitis (AD) is a multifactorial inflammatory skin disease. Its pathogenetic basis is epidermal barrier dysfunction, immune system dysregulation, as well as skin microbiome diversity decrease that occurs due to genetic predisposition. Considering these factors, the skin of patients with AD requires constant care and use of medications with active regenerative properties. The inclusion of anti-inflammatory components in the composition of modern emollients (zinc sulfate and sucralfate) is crucial for restoring the microbiome and immune mechanisms controlling the skin. This article presents data on pathogenetic applicability and clinical efficacy of emollients with anti-inflammatory compounds in patients with AD.

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The authors declare that there are no conflicts of interest present.