vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v21i6.2496vsp-3087Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL ARTICLESОсобенности молекулярного профиля сенсибилизации младенцев из группы риска развития аллергических заболеванийSadchikov Pavel E. Features of Molecular Sensitisation Profile in Infants with Risk of Allergic DiseasesБеляеваИ. А.BelyayevaIrina A.

Москва

Moscow

ТуртиТ. В.TurtiTatyana V.

Татьяна Владимировна Турти, врач-педиатр высшей квалификационной категории, доктор медицинских наук, профессор кафедры факультетской педиатрии педиатрического факультета.

119333, Москва, ул. Фотиевой, д. 10, к. 1

 

Moscow

turtit@mail.ruhttps://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Москва

Moscow

https://orcid.org/0000-0002-6677-2914БомбардироваЕ. П.BombardirovaElena P.

Москва

Moscow

https://orcid.org/0000-0001-7398-0562ВишневаЕ. А.VishnevaElena A.

Москва

Moscow

https://orcid.org/0000-0002-8936-3590КайтуковаЕ. В.KaytukovaElena V.

Москва

Moscow

https://orcid.org/0000-0003-0317-2425ЭфендиеваК. Е.EfendievaKamilla E.

Москва

Moscow

https://orcid.org/0000-0001-6395-028XШукенбаеваР. А.ShukenbaevaR. A.

Москва

Moscow

https://orcid.org/0000-0001-9225-8372СадчиковП. Е.SadchikovPavel E.

Москва

Moscow

Морозовская ДГКБ ДЗМ; НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. ПироговаРоссияMorozovskaya Children’s City Hospital; Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. Пирогова; НИИ организации здравоохранения и медицинского менеджментаРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical ManagementRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. ПироговаРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»РоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryRussian FederationРНИМУ им. Н.И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian Federation202209012023216493500Copyright © Беляева И.А., Турти Т.В., Намазова-Баранова Л.С., Бомбардирова Е.П., Вишнева Е.А., Кайтукова Е.В., Эфендиева К.Е., Шукенбаева Р.А., Садчиков П.Е., 20232023Беляева И.А., Турти Т.В., Намазова-Баранова Л.С., Бомбардирова Е.П., Вишнева Е.А., Кайтукова Е.В., Эфендиева К.Е., Шукенбаева Р.А., Садчиков П.Е.Belyayeva I.A., Turti T.V., Namazova-Baranova L.S., Bombardirova E.P., Vishneva E.A., Kaytukova E.V., Efendieva K.E., Shukenbaeva R.A., Sadchikov P.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3087Обоснование

Обоснование. На сегодняшний день имеется мало данных о характере чувствительности к конкретным антигенам аллергенов у детей первого года жизни с начальными проявлениями аллергии.

Цель исследования — определить особенности первичного профиля молекулярной сенсибилизации у младенцев из группы риска реализации атопических болезней в зависимости от их постнатального возраста.

Методы

Методы. Были обследованы доношенные младенцы, имеющие отягощенный семейный аллергологический анамнез и/или кожные/гастроинтестинальные симптомы аллергии: 1-я группа — 50 детей, возраст — 2,0 [1,0–3,0] мес; 2-я группа — 35 детей, возраст — 9,0 [8,0–11,0] мес.

Результаты

Результаты. Наследственный риск атопии отмечался у 74% (37/50) в 1-й группе и у 71% (25/35) во 2-й. Среди пациентов 1-й группы 38% (19/50) получали грудное вскармливание, среди пациентов 2-й группы — 60% (21/35) детей; прикорм введен в 5,5 [5,0–6,0] мес жизни. Сенсибилизация была зарегистрирована у 10 и 37% детей соответственно. В 1-й группе дети были сенсибилизированы к антигенам пищевых аллергенов: коровье молоко/мясо (Bos d 6, Bos d 8), яичный белок (Gal d 1, Gal d 2, Gal d 3), соя (Gly m 6), креветки (Pen m 4); аэроаллергенов: клещ домашней пыли (Blo t 5, Der h 10), анизакиды (Ani s 3), таракан (Bla g 7). Во 2-й группе была выявлена сенсибилизация к антигенам пищевых аллергенов: коровье молоко (Bos d 6), яичный белок (Gal d 1, Gal d 2), соя (Gly m 6), арахис (Ara h 1, Ara h 2, Ara h 6), киви (Act d 1), пшеница (Tri a 19); аэроаллергенов: кошка (Fel d 1, Fel d 4), пыльца березы (Bet v 1). Поливалентная сенсибилизация была обнаружена у 4 и 6% соответственно.

Заключение

Заключение. Дети первого года жизни имеют гораздо более широкий спектр аллергенов, к которым они чувствительны, чем принято считать. Помимо облигатных пищевых аллергенов, сенсибилизацию вызывают аэроаллергены: клещи домашней пыли, эпидермальные, пыльца березы, перекрестно-реактивный компонент — тропомиозин.

Background

Background. For now, there is little data on sensitivity features to specific allergen antigens in infants with initial allergy manifestations.

Objective

Objective. The aim of the study is to determine the features of the primary molecular sensitisation profile in infants with risk of atopic disease according to their postnatal age.

Methods

Methods. Full-term infants with burdened familial allergic history and/or skin/gastrointestinal allergy symptoms were examined: Group 1 — 50 children, age — 2.0 [1.0–3.0] months; Group 2 — 35 children, age — 9.0 [8.0–11.0] months.

Results

Results. The hereditary atopy risk was observed in 74% of cases (37/50) in Group 1 and in 71% of cases (25/35) in Group 2. 38% of children (19/50) in Group 1 were breastfed, in Group 2 — 60% of children (21/35). Supplemental feeding was implemented in 5.5 [5.0–6.0] months. Sensitisation was reported in 10% and 37% of children. Children of Group 1 were sensitised to food allergen antigens: cow's milk/meat (Bos d 6, Bos d 8), egg-white (Gal d 1, Gal d 2, Gal d 3), soybeans (Gly m 6), shrimps (Pen m 4); airborne allergens: house dust mite (Blo t 5, Der h 10), Anisakidae (Ani s 3), cockroach (Bla g 7). Children of Group 2 were sensitised to food allergen antigens: cow's milk (Bos d 6), egg-white (Gal d 1, Gal d 2), soybeans (Gly m 6), peanut (Ara h 1, Ara h 2, Ara h 6), kiwi (Act d 1), corn (Tri a 19); airborne allergens: cat (Fel d 1, Fel d 4), birch pollen (Bet v 1). Polyvalent sensitisation was revealed in 4% and 6% of cases, respectively.

Conclusion

Conclusion. Infants have much wider range of allergens to which they are sensitive than it is commonly believed. Beside obligate food allergens, sensitisation can be caused by airborne allergens: house dust mites, epidermal, birch pollen; crossreactive component — tropomyosin.

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The authors declare that there are no conflicts of interest present.