vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v22i2.2536vsp-3185Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWВопросы анальгезии и седации новорожденных детей при длительной искусственной вентиляции легкихAnalgesia and Sedation in Newborns with Long-Term Mechanical Ventilationhttps://orcid.org/0000-0003-3445-2956ШестакЕ. В.ShestakEvgenii V.

Шестак Евгений Вячеславович, заведующий отделением реанимации и интенсивной терапии новорождённых Екатеринбургского клинического перинатального центра, ассистент кафедры госпитальной педиатрии педиатрического факультета Уральского государственного медицинского университета

620066, Екатеринбург, ул. Комвузовская, 3

Ekaterinburg

shestakev@yandex.ruhttps://orcid.org/0000-0002-5250-7351КовтунО. П.KovtunOlga P.

Екатеринбург

Ekaterinburg

Екатеринбургский клинический перинатальный центр; Уральский государственный медицинский университетРоссияEkaterinburg Clinical Perinatal Center; Ural State Medical UniversityRussian FederationУральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation202307052023222188194Copyright © Шестак Е.В., Ковтун О.П., 20232023Шестак Е.В., Ковтун О.П.Shestak E.V., Kovtun O.P.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3185

Представлена актуальная информация о медикаментозных препаратах, применяемых для анальгезии и седации новорожденных детей в условиях отделения реанимации при проведении искусственной вентиляции легких. Приведен обзор исследований наиболее часто используемых седативных и анальгетических средств — опиоидов, ацетаминофена, кетамина, мидазолама, дексмедетомидина, пропофола. Представлен анализ их эффективности и риска развития краткосрочных и отдаленных нежелательных эффектов, в том числе связанных с формированием нервной системы ребенка. Обсуждается применение препаратов как в монотерапии, так и в сочетании с другими лекарственными средствами для анальгезии и седации.

Relevant data on drugs used for analgesia and sedation in newborns in the intensive care units during mechanical ventilation is presented. The overview of studies on the most common sedatives and analgesics (opioids, acetaminophen, ketamine, midazolam, dexmedetomidine, propofol) is provided. Analysis of their efficacy and risk of short-term and long-term adverse effects is presented, including those associated with the child’s nervous system development. The use of drugs both as monotherapy and in combination with other medications for analgesia and sedation is being discussed.

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The authors declare that there are no conflicts of interest present.