vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v22i5.2640vsp-3301Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWОсобенности чувствительности золотистого стафилококка к антибиотикам при атопическом дерматите у детейFeatures of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic Dermatitishttps://orcid.org/0000-0003-2252-8570МурашкинН. Н.MurashkinNikolay N.

Москва

Moscow

https://orcid.org/0000-0002-6034-8231МатерикинА. И.MaterikinAlexander I.

Материкин Александр Игоревич - врач-дерматовенеролог отделения дерматологии и аллергологии.

119296, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (495) 967-14-20

Moscow

al_m86@bk.ruhttps://orcid.org/0000-0002-4107-4642ЕпишевР. В.EpishevRoman V.

Москва

Москва

https://orcid.org/0000-0001-5739-0941ЛеоноваМ. А.LeonovaMaria A.

Москва

Moscow

https://orcid.org/0000-0002-0858-8780ОпрятинЛ. А.OpryatinLeonid A.

Москва

Moscow

https://orcid.org/0000-0002-0081-0981ИвановР. А.IvanovRoman A.

Москва

Moscow

https://orcid.org/0000-0001-6884-5171СавеловаА. А.SavelovaAlena A.

Москва

Moscow

НМИЦ здоровья детей; Первый МГМУ им. И.М. Сеченова (Сеченовский Университет); ЦГМАРоссияNational Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University; Central State Medical Academy of Department of Presidential AffairsRussian FederationНМИЦ здоровья детейРоссияNational Medical Research Center of Children’s HealthRussian Federation202305112023225400405Copyright © Мурашкин Н.Н., Материкин А.И., Епишев Р.В., Леонова М.А., Опрятин Л.А., Иванов Р.А., Савелова А.А., 20232023Мурашкин Н.Н., Материкин А.И., Епишев Р.В., Леонова М.А., Опрятин Л.А., Иванов Р.А., Савелова А.А.Murashkin N.N., Materikin A.I., Epishev R.V., Leonova M.A., Opryatin L.A., Ivanov R.A., Savelova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3301Обоснование

Обоснование. При атопическом дерматите (АтД) наблюдается избыточная колонизация кожи различными бактериями и грибами и доля распространенности осложненных вторичной инфекцией форм составляет 30–48%. По данным некоторых исследований, колонизация золотистым стафилококком составляет от 60 до 100% у пациентов с АтД по сравнению с 5–30% у здоровых людей из контрольной группы. Более того, по оценкам специалистов, частота встречаемости изолятов метициллинрезистентных Staphylococcus aureus (MRSA) составляет до 10–30% из культур кожи при АтД. Терапия АтД, осложненного вторичной инфекцией, является одной из важных задач современной дерматологии. Среди топических антибактериальных средств, используемых для этиотропной терапии инфекционных осложнений АтД, можно выделить мупироцин как одно из наиболее эффективных в сравнении с другими, что было подтверждено многочисленными клиническими исследованиями.

Заключение

Заключение. Золотистый стафилококк является наиболее частым триггером обострения АтД. MRSA при АтД, осложненном вторичной инфекцией, тяжело поддаются лечению и становятся устойчивыми ко многим видам антибактериальных средств, при этом демонстрируют сохраняющуюся чувствительность к мупироцину. Наружное средство на основе мупироцина 2% является наиболее эффективным, безопасным и предпочтительным средством лечения АтД, осложненного вторичной инфекцией в детском возрасте.

Background

Background. Excessive colonization of the skin by various bacteria and fungi can be noted in patients with atopic dermatitis (AD), and the prevalence of secondary infection complications 30–48%. Several studies have shown that Staphylococcus aureus colonization is 60–100% in patients with AD compared to 5–30% in healthy persons from the control group. Moreover, the incidence of methicillinresistant Staphylococcus aureus (MRSA) isolates is up to 10–30% in skin cultures at AD, according to experts. Therapy of AD complicated by secondary infection is one of the crucial challenges of modern dermatology. Mupirocin can be considered as one of the most effective topical antibiotic among others used for etiotropic therapy of infectious complications in AD patients, and it has been confirmed by numerous clinical studies.

Conclusion

Conclusion. Staphylococcus aureus is the most common trigger of AD aggravation. MRSA in AD complicated by secondary infection is difficult to manage as it becomes resistant to many types of antibiotics; however, it shows persistent sensitivity to mupirocin. Mupirocin-based (2%) external agent is the most effective, safe, and preferred therapy variant for AD complicated by secondary infection in pediatrics.

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The authors declare that there are no conflicts of interest present.