vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v12i3.683vsp-332Research ArticleВ ПОМОЩЬ ВРАЧУA DOCTOR’S AIDВЛИЯНИЕ ПОЛИМОРФИЗМОВ ГЕНОВ РЕНИН–АНГИОТЕНЗИНОВОЙ СИСТЕМЫ НА ВОЗНИКНОВЕНИЕ НАРУШЕНИЙ РИТМА СЕРДЦА У ДЕТЕЙ С ГИПЕРТРОФИЧЕСКОЙ КАРДИОМИОПАТИЕЙINFLUENCE OF THE POLYMORPHISM OF THE RENIN-ANGIOTENSIN SYSTEM GENES ON THE CARDIAC ARRHYTHMIAS IN CHILDREN WITH HYPERTROPHIC CARDIOMYOPATHYБерезневаН. А.BereznevaN. A.

Berezneva Nataliya Anatol’evna, MD, pediatrician and cardiologist of Department of Rehabilitation of Children with Circulation Diseases of Scientific Center of Children’s Health, RAMS

Address: Lomonosovskii prospect, 2, building 1, Moscow, RF, 119991, Tel.: (499) 134-08-15, e-mail: nberezn@mail.ru

nberezn@mail.ruНемцеваС. Ю.NemtsevaS. Yu.nberezn@mail.ruГромыкоО. Е.GromykoO. E.nberezn@mail.ruАверьяноваН. С.Aver'yanovaN. S.nberezn@mail.ruВашакмадзеН. Д.VashakhmadzeN. D.nberezn@mail.ruБасаргинаЕ. Н.BasarginaE. N.nberezn@mail.ruПинелисВ. Г.PinelisV. G.nberezn@mail.ruНаучный центр здоровья детей РАМН, МоскваРоссияScientific Center of Children's Health, RAMS, MoscowRussian FederationНаучный центр здоровья детей РАМН, Москва,РоссияScientific Center of Children's Health, RAMS, MoscowRussian FederationНаучный центр здоровья детей РАМН, МоскваРоссияScientific Center of Children's Health, RAMSRussian Federation201314052013123Вопросы современной педиатрии6468Copyright © Березнева Н.А., Немцева С.Ю., Громыко О.Е., Аверьянова Н.С., Вашакмадзе Н.Д., Басаргина Е.Н., Пинелис В.Г., 20132013Березнева Н.А., Немцева С.Ю., Громыко О.Е., Аверьянова Н.С., Вашакмадзе Н.Д., Басаргина Е.Н., Пинелис В.Г.Berezneva N.A., Nemtseva S.Y., Gromyko O.E., Aver'yanova N.S., Vashakhmadze N.D., Basargina E.N., Pinelis V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/332 

 

Hypertrophic cardiomyopathy (HCMP) is a genetically determined myocardial disease, characterized by massive hypertrophy of the myocardium of the left and/or (rarely) the right ventricle, often associated with obstruction of the left ventricular outflow tract and diastolic dysfunction. The course of disease can be complicated by development of various cardiac arrhythmias.  It was reported that severity of HCMP course depends at certain degree on polymorphism of candidate genes, including genes of the renin angiotensin system (RAS). Influence of RAS genes polymorphism on the frequency and character of cardiac arrhythmias in childhood is almost not studied. Aim: to determine the influence of RAS genes polymorphism on the prevalence and structure of cardiac arrhythmias in children with HCMP. Patients and methods: analysis of influence of RAS genes polymorphism on the prevalence and structure of cardiac arrhythmias was performed in 32 children with HCMP. All the patients were carried out ECG, cardiac ultrasound and ECG Holter monitoring. Polymorphism of the RAS genes (renin gene (REN) G83A, angiotensinogen gene (AGT) M235T, angiotensin-converting enzyme gene (ACE) I/D, angiotensin II receptor type 1 gene (AGTR1) A1166C). Results: in patients with HCMP was established a higher frequency of TT-genotype and T-alleles of angiotensinogen gene than in comparison group. In homozygous patients with T-allele of angiotensinogen gene ventricular arrhythmia was found reliably more often than in patients with MT- and MM-genotypes, which suggested that M235T polymorphism of angiotensinogen gene influenced on intensity of ventricular arrhythmias in children with HCMP. Conclusions: in children with HCMP and cardiac arrhythmias analysis of M235T polymorphism of angiotensinogen gene can be used as an additional criterion for revealing of patients with high risk of arrhythmic complications and for development of preventative measures.

детигипертрофическая кардиомиопатиянарушения ритма сердцаполиморфизм генов ренинаангиотензиногенаангиотензин-превращающего ферментагена рецептора ангиотензина II 1-го типа.childrenhypertrophic cardiomyopathycardiac arrhythmiaspolymorphism of the renin-angiotensin system genesReferencesTzelujko V. I. J. Health of Ukraine. 2007; 21: 22–23.Tzelujko V. I. J. Health of Ukraine. 2007; 21: 22–23.Tzeluyko V. I., Belostotzaya E. A. J. Medicine of Urgent Conditions. 2009; 1 (20). 3. Leontyeva I. V., Litvinova I. S., Danilenko H. V., Vertshenko E. G. Vestnik of Arhythmology. 2000; 18: 26–27.Tzeluyko V. I., Belostotzaya E. A. J. Medicine of Urgent Conditions. 2009; 1 (20). 3. Leontyeva I. V., Litvinova I. S., Danilenko H. V., Vertshenko E. G. Vestnik of Arhythmology. 2000; 18: 26–27.Golubenko M. V., Puzyrev V. P., Makeeva O. A., Pavlukova E. N. Medical Genetics. 2006;Golubenko M. V., Puzyrev V. P., Makeeva O. A., Pavlukova E. N. Medical Genetics. 2006;(2): 20–28. 5. Marian A. J. Curr. Opin Cardiol. 2002; 17 (3): 242–252.(2): 20–28. 5. Marian A. J. Curr. Opin Cardiol. 2002; 17 (3): 242–252.Belenkov Yu. N., Privalova E. V., Kaplunova V.Yu., Stambolskij D. W., Fomin A. A. J. Cardiology. 2010; 6: 27–33.Belenkov Yu. N., Privalova E. V., Kaplunova V.Yu., Stambolskij D. W., Fomin A. A. J. Cardiology. 2010; 6: 27–33.Ogimoto A., Hamada M., Nakura J., Miki T., Hiwada K. Relation between angiotensin-converting enzyme II genotype and atrial fibrillation in Japanese patients with hypertrophic cardiomyopathy. J. Hum. Genet. 2002; 47 (4): 184–189.Ogimoto A., Hamada M., Nakura J., Miki T., Hiwada K. Relation between angiotensin-converting enzyme II genotype and atrial fibrillation in Japanese patients with hypertrophic cardiomyopathy. J. Hum. Genet. 2002; 47 (4): 184–189.Topal N. P., Ozben B., Hancer V. S., Tanrikulu A. M., DizKucukkaya R. F., Ali S., Basaran Y., Yesildag O. Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation. J. Renin Angiotensin Aldosterone Syst. 2011; 12 (4): 549–556.Topal N. P., Ozben B., Hancer V. S., Tanrikulu A. M., DizKucukkaya R. F., Ali S., Basaran Y., Yesildag O. Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation. J. Renin Angiotensin Aldosterone Syst. 2011; 12 (4): 549–556.Ostroumova O. D. Russian Medical Journal. 2001; 9 (18): 750.Ostroumova O. D. Russian Medical Journal. 2001; 9 (18): 750.Tikhomirova E. A. [Criteria of the prognosis and outcome of hypertrophic cardiomyopathy in children. Ph. D. Thesis]. Moscow, 2007. 27 p.Tikhomirova E. A. [Criteria of the prognosis and outcome of hypertrophic cardiomyopathy in children. Ph. D. Thesis]. Moscow, 2007. 27 p.Katsuya T., Koike G., Yee T. W., Sharpe N., Jackson R., Norton R., Horiuchi M., Pratt R. E., Dzau V. J., MacMahon S. Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. Lancet. 1995; 345: 1600–1603.Katsuya T., Koike G., Yee T. W., Sharpe N., Jackson R., Norton R., Horiuchi M., Pratt R. E., Dzau V. J., MacMahon S. Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. Lancet. 1995; 345: 1600–1603.Tsai C. T., Lai L. P., Lin J. L. Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation. 2004; 109: 1640–1646.Tsai C. T., Lai L. P., Lin J. L. Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation. 2004; 109: 1640–1646.Iravanian S., Dudley S. C. The renin–angiotensin–aldosterone system (RAAS) and cardiac arrhythmias. Heart Rhythm. 2008; 5 (6, Suppl. 1): 12–17.Iravanian S., Dudley S. C. The renin–angiotensin–aldosterone system (RAAS) and cardiac arrhythmias. Heart Rhythm. 2008; 5 (6, Suppl. 1): 12–17.Podzolkov V. I., Bulatov V. A. Russian Medical Journal. 2008; 16 (11): 1517–1523.Podzolkov V. I., Bulatov V. A. Russian Medical Journal. 2008; 16 (11): 1517–1523.Maron B. J., Estes N. A. M. III, Maron M. S., Almquist A. K., Link M. S., Udelson J. Primary prevention of sudden death as a novel treatment strategy in hypertrophic cardiomyopathy. Circulation. 2003; 107: 2872–2875.Maron B. J., Estes N. A. M. III, Maron M. S., Almquist A. K., Link M. S., Udelson J. Primary prevention of sudden death as a novel treatment strategy in hypertrophic cardiomyopathy. Circulation. 2003; 107: 2872–2875.ACC/AHA/ESC 2006 Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Circulation. 2006; 114: 1088–1132.ACC/AHA/ESC 2006 Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Circulation. 2006; 114: 1088–1132.Maron B. J., Spirito P., Win-Kuang S., Haas T. S., Formisano F., Link M. S., Epstein A. E., Almquist A. K., Daubert J. P., Thorsten L., Boriani G., Estes N. A. M., Favale S., Piccininno M., Winters S. L., Santini M., Betocchi S., Arribas F., Sherrid M. V., Buja G., Semsarian C., Bruzzi P. Implantable cardioverter-defibrillators and prevention of sudden cardiac death in hypertrophic cardiomyopathy. JAMA. 2007; 298 (4): 405–412.Maron B. J., Spirito P., Win-Kuang S., Haas T. S., Formisano F., Link M. S., Epstein A. E., Almquist A. K., Daubert J. P., Thorsten L., Boriani G., Estes N. A. M., Favale S., Piccininno M., Winters S. L., Santini M., Betocchi S., Arribas F., Sherrid M. V., Buja G., Semsarian C., Bruzzi P. Implantable cardioverter-defibrillators and prevention of sudden cardiac death in hypertrophic cardiomyopathy. JAMA. 2007; 298 (4): 405–412.

The authors declare that there are no conflicts of interest present.