vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v22i6.2663vsp-3353Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWВведение прикорма: «окно возможностей» формирования кишечной микробиоты и модулирования иммунных реакцийSupplemental Feeding Implementation: Window of Opportunities for the Intestinal Microbiota Development and Immune Responses Modulationhttps://orcid.org/0000-0002-8717-2539БеляеваИ. А.BelyaevaIrina A.

Беляева Ирина Анатольевна - доктор медицинских наук, профессор Российской академии наук, заведующая отделом преконцепционной, антенатальной и неонатальной медицины НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского» Минобрнауки России; профессор кафедры факультетской педиатрии педиатрического факультета ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России; врач-неонатолог ГБУЗ МДКБ ДЗМ

119333, Москва, ул. Фотиевой, д. 10, к. 1

Тел.: +7 (905) 728-58-02

Moscow

irinaneo@mail.ruhttps://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Москва

Moscow

https://orcid.org/0000-0002-6677-2914БомбардироваЕ. П.BombardirovaElena P.

Москва

Moscow

https://orcid.org/0000-0001-6395-028XШукенбаеваР. A.ShukenbayevaRegina A.

Москва

Moscow

https://orcid.org/0000-0002-4955-0121ТуртиТ. В.TurtiTatyana V.

Москва

Moscow

НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. Пирогова; Морозовская ДГКБРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Morozovskaya Children’s City HospitalRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. ПироговаРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»РоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryRussian FederationРНИМУ им. Н.И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. Пирогова; НИИ организации здравоохранения и медицинского менеджментаРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical ManagementRussian Federation202311012024226506512Copyright © Беляева И.А., Намазова-Баранова Л.С., Бомбардирова Е.П., Шукенбаева Р.A., Турти Т.В., 20232023Беляева И.А., Намазова-Баранова Л.С., Бомбардирова Е.П., Шукенбаева Р.A., Турти Т.В.Belyaeva I.A., Namazova-Baranova L.S., Bombardirova E.P., Shukenbayeva R.A., Turti T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3353

В обзоре обобщены сведения об этапах формирования кишечной микробиоты у ребенка первого года жизни и становлении иммунных реакций, сопровождающих эти этапы. Показана определяющая роль грудного вскармливания в формировании оптимальной микробиоты и сопряженных с этим процессом иммунных реакций в первом полугодии жизни. Обоснована биологическая целесообразность введения прикорма на этапе второго «окна возможностей» — начиная с 4–6 мес, а также роль продуктов прикорма (в том числе злакового) в становлении микробиоты взрослого типа.

This review summarizes stages of intestinal microbiota development in infant and immune responses modulation associated to these stages. The leading role of breastfeeding in the optimal microbiota and associated immune responses development during the first half of child’s life is presented. The biological feasibility of supplemental feeding implementation at the second window of opportunity (4–6 months) is justified, as well as role of supplementation products (including cereal) in adult microbiota development.

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The authors declare that there are no conflicts of interest present.