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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/vsp.v12i2.618</article-id><article-id custom-type="elpub" pub-id-type="custom">vsp-344</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕПРЕРЫВНОЕ ПРОФЕССИОНАЛЬНОЕ ОБРАЗОВАНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PROFESSIONAL DEVELOPMENT</subject></subj-group></article-categories><title-group><article-title>Респираторно-синцитиальная вирусная инфекция. Особенности патогенеза, стратегия профилактики и лечения</article-title><trans-title-group xml:lang="en"><trans-title>Respiratory Syncytial Virus Infection. Pathogenesis Peculiarities, Prevention and Treatment Strategies</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кривицкая</surname><given-names>В. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Krivitskaya</surname><given-names>V. Z.</given-names></name></name-alternatives><bio xml:lang="en"><p>Contacts: Krivitskaya Vera Zoryevna, PhD, leading scientific worker of Laboratory of Biotechnology of Diagnostical Medications, Federal State Budget Institution “Scientific Research Institute of Influenza”, Ministry of Health, Russian Federation Address: 197376, St.-Petersburg, Popova str. 15/17, Tel.: (812) 499-15-72, e-mail: vera.kriv@influenza.spb.ru</p></bio><email xlink:type="simple">vera.kriv@influenza.spb.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Научно-исследовательский институт гриппа, Санкт-Петербург<country>Россия</country></aff><aff xml:lang="en">Research Institute of Influenza, Saint-Petersburg<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>19</day><month>03</month><year>2013</year></pub-date><volume>12</volume><issue>2</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>35</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кривицкая В.З., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Кривицкая В.З.</copyright-holder><copyright-holder xml:lang="en">Krivitskaya V.Z.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/344">https://vsp.spr-journal.ru/jour/article/view/344</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>респираторно-синцитиальный вирус</kwd><kwd>особенности патогенеза</kwd><kwd>иммунопатология</kwd><kwd>отдаленные последствия</kwd><kwd>профилактика и лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>respiratory syncytial virus infection</kwd><kwd>peculiarities of pathogenesis</kwd><kwd>immunopathology</kwd><kwd>distant consequences</kwd><kwd>prophylaxis and treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Simoes E. A., Carbonell-Estrany X. Impact of severe disease caused by respiratory syncytial virus in children living in developed countries. Pediatr. Infect. Dis. J. 2003; 22 (Suppl. 2): 13–20.</mixed-citation><mixed-citation xml:lang="en">Simoes E. A., Carbonell-Estrany X. Impact of severe disease caused by respiratory syncytial virus in children living in developed countries. Pediatr. Infect. Dis. J. 2003; 22 (Suppl. 2): 13–20.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Nair H., Nokes D. J., Gessner B. D., Dherani M., Madhi S. A., Singleton R. J., O'Brien K. L., Roca A., Wright P. F., Bruce N., Chandran A., Theodoratou E., Sutanto A., Sedyaningsih E. R., Ngama M., Munywoki P. K., Kartasasmita C., Simoes E. A., Rudan I., Weber M. W., Campbell H. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010; 375 (9725): 1545–1555.</mixed-citation><mixed-citation xml:lang="en">Nair H., Nokes D. J., Gessner B. D., Dherani M., Madhi S. A., Singleton R. J., O'Brien K. L., Roca A., Wright P. F., Bruce N., Chandran A., Theodoratou E., Sutanto A., Sedyaningsih E. R., Ngama M., Munywoki P. K., Kartasasmita C., Simoes E. A., Rudan I., Weber M. W., Campbell H. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010; 375 (9725): 1545–1555.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Karron R. A. Respiratory syncytial virus and parainfluenza virus vaccines. In: S. A. Plotkin, W. A. Orenstein, P. A. Offit (eds). Vaccines, 6th edn. Elsevier Inc. Saunders. 2012. P. 1146–1153.</mixed-citation><mixed-citation xml:lang="en">Karron R. A. Respiratory syncytial virus and parainfluenza virus vaccines. In: S. A. Plotkin, W. A. Orenstein, P. A. Offit (eds). Vaccines, 6th edn. Elsevier Inc. Saunders. 2012. P. 1146–1153.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Welliver R. C., Checchia P. A., Bauman J. H., Fernandes A. W., Mahadevia P. J., Hall C. B. Fatality rates in published reports of RSV hospitalizations among high-risk and otherwise healthy children. Curr. Med. Res. Opin. 2010; 26 (9): 2175–2181.</mixed-citation><mixed-citation xml:lang="en">Welliver R. C., Checchia P. A., Bauman J. H., Fernandes A. W., Mahadevia P. J., Hall C. B. Fatality rates in published reports of RSV hospitalizations among high-risk and otherwise healthy children. Curr. Med. Res. Opin. 2010; 26 (9): 2175–2181.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Hon K. L., Leung T. F., Cheng W. Y., Ko N. M., Tang W. K., Wong W. W., Yeung W. H., Chan P. K. Respiratory syncytial virus morbidity, premorbid factors, seasonality, and implications for prophylaxis. J. Crit. Care. 2012; 27 (5): 464–468. 6</mixed-citation><mixed-citation xml:lang="en">Hon K. L., Leung T. F., Cheng W. Y., Ko N. M., Tang W. K., Wong W. W., Yeung W. H., Chan P. K. Respiratory syncytial virus morbidity, premorbid factors, seasonality, and implications for prophylaxis. J. Crit. Care. 2012; 27 (5): 464–468. 6</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">. Whimbey E., Ghosh S. Respiratory syncytial virus infections in immunocompromised adults. Curr. Clin.Top. Infect. Dis. 2000; 20: 232–255.</mixed-citation><mixed-citation xml:lang="en">. Whimbey E., Ghosh S. Respiratory syncytial virus infections in immunocompromised adults. Curr. Clin.Top. Infect. Dis. 2000; 20: 232–255.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Walsh E. E. Respiratory syncytial virus infection in adults. Semin. Respir. Crit. Care. Med. 2011; 32 (4): 423–432.</mixed-citation><mixed-citation xml:lang="en">Walsh E. E. Respiratory syncytial virus infection in adults. Semin. Respir. Crit. Care. Med. 2011; 32 (4): 423–432.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rumel N. B., Gonchar V. A., Shilova Ye. R., Bessmeltsev S. S., Strizhakh N. P., Zalimko L. A., Krivitskaya V. Z., Chebotkhevich V. N. Оpeculiarities of respiratory-syncytial infections in patients with hemoblastosis and depression of haematopoesis. Epidemiology and infectious diseases. 2008; 5: 45–49.</mixed-citation><mixed-citation xml:lang="en">Rumel N. B., Gonchar V. A., Shilova Ye. R., Bessmeltsev S. S., Strizhakh N. P., Zalimko L. A., Krivitskaya V. Z., Chebotkhevich V. N. Оpeculiarities of respiratory-syncytial infections in patients with hemoblastosis and depression of haematopoesis. Epidemiology and infectious diseases. 2008; 5: 45–49.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lamb R. A., Parks G. D. Paramyxoviridae: the viruses and their replication. In: D. M. Knipe, P. M. Howley (eds). Fields Virology. 5.1. Wolters Kluver: Lippencott Williams and Wilkins. 2007. P. 1449–1496.</mixed-citation><mixed-citation xml:lang="en">Lamb R. A., Parks G. D. Paramyxoviridae: the viruses and their replication. In: D. M. Knipe, P. M. Howley (eds). Fields Virology. 5.1. Wolters Kluver: Lippencott Williams and Wilkins. 2007. P. 1449–1496.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmer G., Budz L., Herrler G. Proteolytic activation of respiratory syncytial virus fusion protein. Cleavage at two furin consensus sequences. J. Biol. Chem. 2001; 276 (34): 31642–3150.</mixed-citation><mixed-citation xml:lang="en">Zimmer G., Budz L., Herrler G. Proteolytic activation of respiratory syncytial virus fusion protein. Cleavage at two furin consensus sequences. J. Biol. Chem. 2001; 276 (34): 31642–3150.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Horimoto T., Kawaoka Y. Pandemic threat posed by avian influenza A viruses. Clin. Microbiol. Rev. 2001; 14 (1): 129–149.</mixed-citation><mixed-citation xml:lang="en">Horimoto T., Kawaoka Y. Pandemic threat posed by avian influenza A viruses. Clin. Microbiol. Rev. 2001; 14 (1): 129–149.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cane P. A., Thomas H. M., Simpson A. F., Evans J. E., Hart C. A., Pringle C. R. Analysis of the human serological immune response to a variable region of the attachment (G) protein of respiratory syncytial virus during primary infection. J. Med. Virol. 1996; 48 (3): 253–261.</mixed-citation><mixed-citation xml:lang="en">Cane P. A., Thomas H. M., Simpson A. F., Evans J. E., Hart C. A., Pringle C. R. Analysis of the human serological immune response to a variable region of the attachment (G) protein of respiratory syncytial virus during primary infection. J. Med. Virol. 1996; 48 (3): 253–261.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bukreyev A., Yang L., Fricke J., Cheng L., Ward J. M., Murphy B. R., Collins P. L. The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes. J. Virol. 2008; 82 (24): 12191–12204.</mixed-citation><mixed-citation xml:lang="en">Bukreyev A., Yang L., Fricke J., Cheng L., Ward J. M., Murphy B. R., Collins P. L. The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes. J. Virol. 2008; 82 (24): 12191–12204.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mohan G. S., Li W., Ye L., Compans R. W., Yang C. Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus. PLoS Pathog. 2012; 8 (12): 1003065.</mixed-citation><mixed-citation xml:lang="en">Mohan G. S., Li W., Ye L., Compans R. W., Yang C. Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus. PLoS Pathog. 2012; 8 (12): 1003065.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cheshik S. G., Vartanyan R. V. Respiratory-syncytial viral infection — clinic, diagnostics, treatment. Children’s infections. 2004; 1: 43–49.</mixed-citation><mixed-citation xml:lang="en">Cheshik S. G., Vartanyan R. V. Respiratory-syncytial viral infection — clinic, diagnostics, treatment. Children’s infections. 2004; 1: 43–49.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Eisenhut M. Extrapulmonary manifestations of severe respiratory syncytial virus infection — a systematic review. Crit. Care. 2006; 10 (4): 107.</mixed-citation><mixed-citation xml:lang="en">Eisenhut M. Extrapulmonary manifestations of severe respiratory syncytial virus infection — a systematic review. Crit. Care. 2006; 10 (4): 107.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Guerrero–Plata A., Casola A., Suarez G., Yu X., Spetch L., Peeples M. E., Garofalo R. P. Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 2006; 34 (3): 320–329.</mixed-citation><mixed-citation xml:lang="en">Guerrero–Plata A., Casola A., Suarez G., Yu X., Spetch L., Peeples M. E., Garofalo R. P. Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 2006; 34 (3): 320–329.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Welliver R. C. The immune response to respiratory syncytial virus infection: friend or foe? Clin. Rev. Allergy. Immunol. 2008; 34 (2): 163–173.</mixed-citation><mixed-citation xml:lang="en">Welliver R. C. The immune response to respiratory syncytial virus infection: friend or foe? Clin. Rev. Allergy. Immunol. 2008; 34 (2): 163–173.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bueno S. M., Gonzalez P. A., Riedel C. A., Carreno L. J., Vasquez A. E., Kalergis A. M. Local cytokine response upon respiratory syncytial virus infection. Immunol. Lett. 2011; 136 (2): 122–129.</mixed-citation><mixed-citation xml:lang="en">Bueno S. M., Gonzalez P. A., Riedel C. A., Carreno L. J., Vasquez A. E., Kalergis A. M. Local cytokine response upon respiratory syncytial virus infection. Immunol. Lett. 2011; 136 (2): 122–129.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Openshaw P. J., Pemberton R. M., Ball L. A., Wertz G. W., Askonas B. A. Helper T cell recognition of respiratory syncytial virus in mice. J. Gen. Virol. 1988; 69 (2): 305–312.</mixed-citation><mixed-citation xml:lang="en">Openshaw P. J., Pemberton R. M., Ball L. A., Wertz G. W., Askonas B. A. Helper T cell recognition of respiratory syncytial virus in mice. J. Gen. Virol. 1988; 69 (2): 305–312.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Glezen W., Paredes A., Allison J., Taber L. H., Frank A. L. Risk of respiratory syncytial virus infection for infants from low income families in relationship to age, sex, ethnic group, and maternal antibody level. J. Pediatr. 1981; 98: 708–715.</mixed-citation><mixed-citation xml:lang="en">Glezen W., Paredes A., Allison J., Taber L. H., Frank A. L. Risk of respiratory syncytial virus infection for infants from low income families in relationship to age, sex, ethnic group, and maternal antibody level. J. Pediatr. 1981; 98: 708–715.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Siegrist C. A. Mechanisms by which maternal antibodies influen ce infant vaccine responses: review of hypotheses and definition of main determinants. Vaccine. 2003; 21: 3406–3412.</mixed-citation><mixed-citation xml:lang="en">Siegrist C. A. Mechanisms by which maternal antibodies influen ce infant vaccine responses: review of hypotheses and definition of main determinants. Vaccine. 2003; 21: 3406–3412.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Stensballe L. G., Ravn H., Kristensen K., Agerskov K., Meakins T., Aaby P., Simoes E. A. Comparison of nasopharyngeal aspirate and nasal swab specimens for detection of respiratory syncytial virus in different settings in a developing country. Trop. Med. Int. Health. 2002; 7 (4): 317–321.</mixed-citation><mixed-citation xml:lang="en">Stensballe L. G., Ravn H., Kristensen K., Agerskov K., Meakins T., Aaby P., Simoes E. A. Comparison of nasopharyngeal aspirate and nasal swab specimens for detection of respiratory syncytial virus in different settings in a developing country. Trop. Med. Int. Health. 2002; 7 (4): 317–321.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Krivitskaya V. Z., Voytsekhovskaya Ye. M., Sukhovetskaya V. F., Golovacheva Ye. G., Lvov N. I., Sominina A. A. The role of preceding virus-specific IgG in pathogenesis of respiratory-syncytial viral infection in initial and recurrent diseases. Infection and immunity. 2012; 2 (4): 705–714.</mixed-citation><mixed-citation xml:lang="en">Krivitskaya V. Z., Voytsekhovskaya Ye. M., Sukhovetskaya V. F., Golovacheva Ye. G., Lvov N. I., Sominina A. A. The role of preceding virus-specific IgG in pathogenesis of respiratory-syncytial viral infection in initial and recurrent diseases. Infection and immunity. 2012; 2 (4): 705–714.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Oshansky C. M., Zhang W., Moore E., Tripp R. A. The host response and molecular pathogenesis associated with respiratory syncytial virus infection. Future Microbiol. 2009; 4: 279–297.</mixed-citation><mixed-citation xml:lang="en">Oshansky C. M., Zhang W., Moore E., Tripp R. A. The host response and molecular pathogenesis associated with respiratory syncytial virus infection. Future Microbiol. 2009; 4: 279–297.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Lukacs N. W., Smit J. J., Mukherjee S., Morris S. B., Nunez G., Lindell D. M. Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation. J. Immunol. 2010; 185 (4): 2231–2239.</mixed-citation><mixed-citation xml:lang="en">Lukacs N. W., Smit J. J., Mukherjee S., Morris S. B., Nunez G., Lindell D. M. Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation. J. Immunol. 2010; 185 (4): 2231–2239.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Bartz H., Buning-Pfaue F., Turkel O., Schauer U. Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells. Clin. Exp. Immunol. 2002; 129 (3): 438–445.</mixed-citation><mixed-citation xml:lang="en">Bartz H., Buning-Pfaue F., Turkel O., Schauer U. Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells. Clin. Exp. Immunol. 2002; 129 (3): 438–445.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Munir S., Le Nouen C., Luongo C., Buchholz U. J., Collins P. L., Bukreyev A. Nonstructural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells. J. Virol. 2008; 82 (17): 8780–8796.</mixed-citation><mixed-citation xml:lang="en">Munir S., Le Nouen C., Luongo C., Buchholz U. J., Collins P. L., Bukreyev A. Nonstructural proteins 1 and 2 of respiratory syncytial virus suppress maturation of human dendritic cells. J. Virol. 2008; 82 (17): 8780–8796.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Avadhanula V., Rodriguez C. A., Devincenzo J. P., Wang Y., Webby R. J., Ulett G. C., Adderson E. E. Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner. J. Virol. 2006; 80 (4): 1629–1636.</mixed-citation><mixed-citation xml:lang="en">Avadhanula V., Rodriguez C. A., Devincenzo J. P., Wang Y., Webby R. J., Ulett G. C., Adderson E. E. Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner. J. Virol. 2006; 80 (4): 1629–1636.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Aung S., Graham B. S. IL-4 diminishes perforin-mediated and increases Fas ligand-mediated cytotoxicity in vivo. J. Immunol. 2000; 164 (7): 3487–3493.</mixed-citation><mixed-citation xml:lang="en">Aung S., Graham B. S. IL-4 diminishes perforin-mediated and increases Fas ligand-mediated cytotoxicity in vivo. J. Immunol. 2000; 164 (7): 3487–3493.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kimpen J. L. Respiratory syncytial virus and asthma. The role of monocytes. Am. J. Respir. Crit. Care Med. 2001; 163 (3, Pt. 2): 7–9.</mixed-citation><mixed-citation xml:lang="en">Kimpen J. L. Respiratory syncytial virus and asthma. The role of monocytes. Am. J. Respir. Crit. Care Med. 2001; 163 (3, Pt. 2): 7–9.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lucey D. R., Clerichi M., Shearer G. M. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin. Microbiol. Rev. 1996; 9 (4): 532–562.</mixed-citation><mixed-citation xml:lang="en">Lucey D. R., Clerichi M., Shearer G. M. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clin. Microbiol. Rev. 1996; 9 (4): 532–562.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Byeon J. H., Lee J. C., Choi I. S., Yoo Y., Park S. H., Choung J. T. Comparison of cytokine responses in nasopharyngeal aspirates from children with viral lower respiratory tract infections. Acta Paediatr. 2009; 98 (4): 725–730.</mixed-citation><mixed-citation xml:lang="en">Byeon J. H., Lee J. C., Choi I. S., Yoo Y., Park S. H., Choung J. T. Comparison of cytokine responses in nasopharyngeal aspirates from children with viral lower respiratory tract infections. Acta Paediatr. 2009; 98 (4): 725–730.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Han J., Jia Y., Takeda K., Shiraishi Y., Okamoto M., Dakhama A., Gelfand E. W. Montelukast during primary infection prevents airway hyperresponsiveness and inflammation after reinfection with respiratory syncytial virus. Am. J. Respir. Crit. Care. Med. 2010; 182 (4): 455–463.</mixed-citation><mixed-citation xml:lang="en">Han J., Jia Y., Takeda K., Shiraishi Y., Okamoto M., Dakhama A., Gelfand E. W. Montelukast during primary infection prevents airway hyperresponsiveness and inflammation after reinfection with respiratory syncytial virus. Am. J. Respir. Crit. Care. Med. 2010; 182 (4): 455–463.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Wright M., Piedimonte G. Respiratory syncytial virus prevention and therapy: past, present, and future. Pediatr. Pulmonol. 2011; 46 (4): 324–347.</mixed-citation><mixed-citation xml:lang="en">Wright M., Piedimonte G. Respiratory syncytial virus prevention and therapy: past, present, and future. Pediatr. Pulmonol. 2011; 46 (4): 324–347.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Krivitsksya V. Z., Sominina A. A., Suchovetskaya V. F., Milkint K. K., Sverlova M. V. Immunopathological allergic Th2-type of antiviral humoral immune response in children with respiratory-syncytial viral infection. Cytokines and inflammation. 2004; 3 (3): 34–41.</mixed-citation><mixed-citation xml:lang="en">Krivitsksya V. Z., Sominina A. A., Suchovetskaya V. F., Milkint K. K., Sverlova M. V. Immunopathological allergic Th2-type of antiviral humoral immune response in children with respiratory-syncytial viral infection. Cytokines and inflammation. 2004; 3 (3): 34–41.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Hancock G. E., Tebbey P. W., Scheuer C. A., Pryharski K. S., Heers K. M., LaPierre N. A. Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes. J. Med. Virol. 2003; 70 (2): 301–308.</mixed-citation><mixed-citation xml:lang="en">Hancock G. E., Tebbey P. W., Scheuer C. A., Pryharski K. S., Heers K. M., LaPierre N. A. Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes. J. Med. Virol. 2003; 70 (2): 301–308.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Harcourt J., Alvarez R., Jones L. P., Henderson C., Anderson L. J., Tripp R. A. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect X3CR1+ T cell responses. J. Immunol. 2006; 176 (3): 1600–1608.</mixed-citation><mixed-citation xml:lang="en">Harcourt J., Alvarez R., Jones L. P., Henderson C., Anderson L. J., Tripp R. A. Respiratory syncytial virus G protein and G protein CX3C motif adversely affect X3CR1+ T cell responses. J. Immunol. 2006; 176 (3): 1600–1608.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Yakovleva N. V., Pokhodzey I. V., Tovt-Korshinskaya M. I., Sukhovskaya O. A. Peculiarities of viral infections in patients with chronic obstructive bronchitis. Therapeutic archive. 1987; 7: 47–50.</mixed-citation><mixed-citation xml:lang="en">Yakovleva N. V., Pokhodzey I. V., Tovt-Korshinskaya M. I., Sukhovskaya O. A. Peculiarities of viral infections in patients with chronic obstructive bronchitis. Therapeutic archive. 1987; 7: 47–50.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Castro M., Schweiger T., Yin–Declue H., Ramkumar T. P., Christie C., Zheng J., Cohen R., Schechtman K. B., Strunk R., Bacharier L. B. Cytokine response after severe respiratory syncytial virus bronchiolitis in early life. J. Allergy. Clin. Immunol. 2008; 122 (4): 726–733.</mixed-citation><mixed-citation xml:lang="en">Castro M., Schweiger T., Yin–Declue H., Ramkumar T. P., Christie C., Zheng J., Cohen R., Schechtman K. B., Strunk R., Bacharier L. B. Cytokine response after severe respiratory syncytial virus bronchiolitis in early life. J. Allergy. Clin. Immunol. 2008; 122 (4): 726–733.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Sigurs N., Bjarnason R., Sigurbergsson F. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am. J. Respir. Crit. Care. Med. 2000; 161: 1501–1507.</mixed-citation><mixed-citation xml:lang="en">Sigurs N., Bjarnason R., Sigurbergsson F. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am. J. Respir. Crit. Care. Med. 2000; 161: 1501–1507.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kim H. W., Canchola J. G., Brandt C. D., Pyles G., Chanock R. M., Jensen K., Parrott R. H. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am. J. Epidemiol. 1969; 89 (4): 422–434.</mixed-citation><mixed-citation xml:lang="en">Kim H. W., Canchola J. G., Brandt C. D., Pyles G., Chanock R. M., Jensen K., Parrott R. H. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am. J. Epidemiol. 1969; 89 (4): 422–434.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Boukhvalova M. S., Prince G. A., Soroush L., Harrigan D. C., Vogel S. N., Blanco J. C. The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus 35.</mixed-citation><mixed-citation xml:lang="en">Boukhvalova M. S., Prince G. A., Soroush L., Harrigan D. C., Vogel S. N., Blanco J. C. The TLR4 agonist, monophosphoryl lipid A, attenuates the cytokine storm associated with respiratory syncytial virus 35.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Yu D. X., Chen Q., Zhang L. L., Liu Y., Yu Z. A., Li Z. F., Zhang L. P., Hu G. F., Duan Z. J., Chu X. W., Zhang B., Yu S. Y., Hou Y. D. A field trial of recombinant human interferon alpha–2b for nasal spray to prevent SARS and other respiratory viral infections. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2005; 19 (3): 216–219.</mixed-citation><mixed-citation xml:lang="en">Yu D. X., Chen Q., Zhang L. L., Liu Y., Yu Z. A., Li Z. F., Zhang L. P., Hu G. F., Duan Z. J., Chu X. W., Zhang B., Yu S. Y., Hou Y. D. A field trial of recombinant human interferon alpha–2b for nasal spray to prevent SARS and other respiratory viral infections. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2005; 19 (3): 216–219.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Randolph A. G., Wang E. E. Ribavirin for respiratory syncytial virus infection of the lower respiratory tract. Cochr. Database Syst. Rev. 2004; 4: CD000181.</mixed-citation><mixed-citation xml:lang="en">Randolph A. G., Wang E. E. Ribavirin for respiratory syncytial virus infection of the lower respiratory tract. Cochr. Database Syst. Rev. 2004; 4: CD000181.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Frogel M. P., Stewart D. L., Hoopes M., Fernandes A. W., Mahadevia P. J. A systematic review of compliance with palivizumab administration for RSV immunoprophylaxis. J. Manag. Care. Pharm. 2010; 16 (1): 46–58.</mixed-citation><mixed-citation xml:lang="en">Frogel M. P., Stewart D. L., Hoopes M., Fernandes A. W., Mahadevia P. J. A systematic review of compliance with palivizumab administration for RSV immunoprophylaxis. J. Manag. Care. Pharm. 2010; 16 (1): 46–58.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Hu J., Robinson J. L. Treatment of respiratory syncytial virus with palivizumab: a systematic review. World J. Pediatr. 2010; 6 (4): 296–300.</mixed-citation><mixed-citation xml:lang="en">Hu J., Robinson J. L. Treatment of respiratory syncytial virus with palivizumab: a systematic review. World J. Pediatr. 2010; 6 (4): 296–300.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
