vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v23i2.2722vsp-3448Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWРоль витамина D в патогенезе воспалительных заболеваний кишечника: обзор литературыRole of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Reviewhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinAnatoly I.

Хавкин Анатолий Ильич - доктор медицинских наук, профессор, заведующий кафедрой гастроэнтерологии и диетологии им. А.В. Мазурина, руководитель Московского областного центра детской гастроэнтерологии и гепатологии НИКИ детства Минздрава Московской области; профессор кафедры педиатрии с курсом детских хирургических болезней Медицинского института НИУ БелГУ.

115093, Москва, ул. Большая Серпуховская, 62

Тел.: +7 (499) 237-02-23

Moscow; Belgorod

gastropedclin@gmail.comhttps://orcid.org/0000-0002-4733-3262НалетовА. В.NalyotovAndrew V.

Донецк

Donetsk

https://orcid.org/0000-0002-7880-8056МасютаД. И.MasyutaDmitry I.

Донецк

Donetsk

https://orcid.org/0000-0002-4562-7515МахмутовР. Ф.MakhmutovRavil F.

Донецк

Donetsk

Научно-исследовательский клинический институт детства Минздрава Московской области; Белгородский государственный национальный исследовательский университетРоссияResearch and Clinical Institute for Children; Belgorod State UniversityRussian FederationДонГМУ им. М. ГорькогоРоссияDonetsk State Medical University named after M. GorkyRussian Federation2024050520242325862Copyright © Хавкин А.И., Налетов А.В., Масюта Д.И., Махмутов Р.Ф., 20242024Хавкин А.И., Налетов А.В., Масюта Д.И., Махмутов Р.Ф.Khavkin A.I., Nalyotov A.V., Masyuta D.I., Makhmutov R.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3448

На сегодняшний день патогенез воспалительных заболеваний кишечника остается не до конца изученным. Генетическая предрасположенность, нарушение иммунной регуляции, нарушение состава кишечной микробиоты, воздействие экологических факторов связаны с развитием воспаления слизистой оболочки кишечника и повышением эпителиальной проницаемости, что лежит в основе развития и прогрессирования заболевания. В научной литературе существует теория о том, что среди факторов окружающей среды дефицит витамина D увеличивает риск возникновения воспалительных заболеваний кишечника. Однако изучение роли витамина D в развитии заболеваний желудочно-кишечного тракта остается малоисследованной проблемой. В статье представлены современные сведения, касающиеся влияния витамина D на барьерную функцию слизистой оболочки кишечника, иммунную систему и кишечную микробиоту в контексте звеньев патогенеза воспалительных заболеваний кишечника.

The pathogenesis of inflammatory bowel diseases still remains unclear nowadays. Genetic disposition, impaired immune regulation, disturbance in intestinal microbiota composition, exposure to environmental factors are associated with the development of inflammation in intestinal mucosa and increased epithelial penetrance that define disease's development and progression. There is a theory in scientific literature that vitamin D deficiency (among other environmental factors) increases the risk of inflammatory bowel disease. However, the role of vitamin D in the development of gastrointestinal tract diseases remains poorly studied. This article presents current data on the vitamin D effect on the intestinal mucosa barrier function, on the immune system and on the intestinal microbiota in the context of inflammatory bowel diseases pathogenesis.

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The authors declare that there are no conflicts of interest present.