vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v23i3.2768vsp-3519Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWСовременные представления о воспалительных заболеваниях кишечника у детей с очень ранним и ранним началомModern View on Very Early Onset and Early Onset Inflammatory Bowel Diseases in Childrenhttps://orcid.org/0000-0001-7308-7280ХавкинА. И.KhavkinAnatoly I.

Хавкин Анатолий Ильич - доктор медицинских наук, профессор, заведующий кафедрой гастроэнтерологии и диетологии им. А.В. Мазурина, руководитель Московского областного центра детской гастроэнтерологии и гепатологии НИКИ детства Минздрава Московской области, профессор кафедры педиатрии с курсом детских хирургических болезней МИ ФГАОУ ВО НИУ «БелГУ» МР.

115093, Москва, ул. Большая Серпуховская, 62, тел.: +7 (499) 237-02-23

Mytishchi, Belgorod

gastropedclin@gmail.comhttps://orcid.org/0009-0002-7103-6468ПермяковаА. А.PermyakovaAnastasiya A.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0002-6640-2155ЦепиловаМ. О.TsepilovaMariya O.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0001-6939-6961КаплинаА. В.KaplinaAleksandra V.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0003-0331-0963СиткинС. И.SitkinStanislav I.

Санкт-Петербург

Saint Petersburg

https://orcid.org/0000-0002-3697-4283СурковА. Н.SurkovAndrey N.

Москва

Moscow

https://orcid.org/0009-0004-1751-1293ГетмановС. Д.GetmanovStanislav D.

Москва

Moscow

НИКИ детства; НИУ «БелГУ»РоссияResearch and Clinical Institute for Children; Belgorod State UniversityRussian FederationСПбГПМУРоссияSaint Petersburg State Pediatric Medical UniversityRussian FederationНМИЦ им. В.А. АлмазоваРоссияAlmazov National Medical Research CentreRussian FederationНМИЦ им. В.А. Алмазова; СЗГМУ им. И.И. МечниковаРоссияAlmazov National Medical Research Centre; North-Western State Medical University named after I.I. MechnikovRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. ПироговаРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian FederationРНИМУ им. Н.И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian Federation202412072024233145151Copyright © Хавкин А.И., Пермякова А.А., Цепилова М.О., Каплина А.В., Ситкин С.И., Сурков А.Н., Гетманов С.Д., 20242024Хавкин А.И., Пермякова А.А., Цепилова М.О., Каплина А.В., Ситкин С.И., Сурков А.Н., Гетманов С.Д.Khavkin A.I., Permyakova A.A., Tsepilova M.O., Kaplina A.V., Sitkin S.I., Surkov A.N., Getmanov S.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3519

На сегодняшний день актуальной проблемой детской гастроэнтерологии является изучение воспалительных заболеваний кишечника с очень ранним началом (ВЗК-ОРН), которые имеют уникальные генетические, клинические, иммунологические, морфологические, лабораторные признаки. Считается, что ВЗК-ОРН зачастую является моногенным заболеванием, особенно в сочетании с врожденными дефектами иммунитета, что приводит к трудностям диагностики и лечения этой патологии. Несмотря на это, систематизация сведений о данной группе нозологических форм ВЗК практически не проводится. В статье представлен обзор имеющейся информации об этиологических факторах, вариантах течения и возможностях терапии ВЗК-ОРН.

Nowadays, an urgent problem of pediatric gastroenterology is the study of inflammatory bowel diseases with very early onset (VEO-IBD), which have unique genetic, clinical, immunological, morphological, and laboratory sings. Early VEO-IBD is usually considered as monogenic disease, especially in combination with congenital immune defects, which leads to difficulties in diagnosis and management this pathology. Despite this, systematization of information about this group of nosological forms of IBD is practically not carried out. This article presents a review of the available information on etiological factors, course variants, and therapeutic options for VEO-IBD.

воспалительные заболевания кишечника с ранним началомвоспалительные заболевания кишечника с очень ранним началомболезнь Кронаязвенный колитнедифференцированный колитнекротизирующий энтероколитearly onset inflammatory bowel diseasevery early onset inflammatory bowel diseaseCrohn's diseaseulcerative colitisindeterminate colitisnecrotizing enterocolitisОтсутствуетNot declaredReferencesOuahed J, Spencer E, Kotlarz D, et al. Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies. Inflamm Bowel Dis. 2020;26(6):820–842. https://doi.org/10.1093/ibd/izz259Ouahed J, Spencer E, Kotlarz D, et al. Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies. Inflamm Bowel Dis. 2020;26(6):820–842. https://doi.org/10.1093/ibd/izz259Kuenzig ME, Fung SG, Marderfeld L, et al. 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The authors declare that there are no conflicts of interest present.