vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v12i2.630vsp-356Research ArticleВ ПОМОЩЬ ВРАЧУA DOCTOR’S AIDЭффективность применения 7-валентной пневмококковой вакцины для профилактики пневмококковой инфекции у детей г. Новосибирска из групп рискаEfficacy of usage of pneumococcal 7-valent vaccine in prophylaxis of pneumococcal infection in Novosibirsk children from risk groupsБелецкаяО. А.BeletskayaO. A.natalya_kuhtinov@mail.ruГорбатыхЮ. Н.GorbatykhYu.N.natalya_kuhtinov@mail.ruШмаковА. Н.ShmakovA. N.natalya_kuhtinov@mail.ruИшалинаН. Ю.IshalinaN. Yu.natalya_kuhtinov@mail.ruИвлеваТ. Ю.IvlevaT. Yu.natalya_kuhtinov@mail.ruКухтиноваН. В.KukhtinovaN. V.

Contacts: Kukhtinova Natalya Vladilenovna, PhD, MD, assistant of a Chair of Pediatrics, Novosibirsk State Medical University Address: 630091, Novosibirsk, Krasnyy Prospect, 52, Tel.: (383) 223-67-21, e-mail: natalya_kuhtinov@mail.ru

natalya_kuhtinov@mail.ruОтдел родовспоможения и организации специализированной помощи детскому населению мэрии г. НовосибирскаDepartment of Obstetrics and Organization of Specialized Medical Care to Children of the Novosibirsk City Administration, Russian FederationНовосибирский НИИ патологии кровообращения им. акад. Е.Н. МешалкинаРоссияE.N. Meshalkin Novosibirsk Scientific Research Institute of Blood Circulation Disorders,Russian FederationНовосибирский государственный медицинский университетРоссияNovosibirsk State Medical UniversityRussian FederationДетская городская клиническая больница № 4 им. Гераськова, НовосибирскРоссияGeras’kov Children Municipal Clinical Hospital №4, NovosibirskRussian FederationГородская детская поликлиника № 2, НовосибирскРоссияMunicipal Children Out-Patient Clinic №2, NovosibirskRussian Federation201319032013122Вопросы современной педиатрии123126Copyright © Белецкая О.А., Горбатых Ю.Н., Шмаков А.Н., Ишалина Н.Ю., Ивлева Т.Ю., Кухтинова Н.В., 20132013Белецкая О.А., Горбатых Ю.Н., Шмаков А.Н., Ишалина Н.Ю., Ивлева Т.Ю., Кухтинова Н.В.Beletskaya O.A., Gorbatykh Y., Shmakov A.N., Ishalina N.Y., Ivleva T.Y., Kukhtinova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/356

С целью профилактики заболеваемости и детской смертности в 2011 г. за счет средств муниципального бюджета г. Новосибирска осуществлена вакцинация 7-валентной пневмококковой конъюгированной вакциной 116 детей двух групп риска: больных с бронхолегочной дисплазией и врожденными пороками сердца в возрасте от 6 мес до 5 лет. Из 116 наблюдаемых обеих групп внебольничную пневмонию в анамнезе перенесли 16 (14%), что в 22 раза превышает заболеваемость указанной патологией среди детей региона в целом. Годовое динамическое наблюдение показало значимое снижение заболеваемости внебольничными пневмониями в группах риска: с 16/116 (14%) до 1/75 (1%) (р = 0,006). Среди вакцинированных детей не зарегистрировано ни одного случая инвазивных пневмококковых инфекций, у 87,5% привитых снизилась общая заболеваемость. Частота общих поствакцинальных реакций средней степени тяжести составила 1,8%, частота местных реакций — 0,9%. Других неблагоприятных явлений в поствакцинальном периоде отмечено не было. Таким образом, проведенная на территории Новосибирска вакцинация против пневмококковой инфекции детей, входящих в группу риска фатальных осложнений, доказала высокую эффективность и безопасность используемой вакцины.

In order to prevent children morbidity and mortality 116 children aged from 6 months to 5 years from 2 risk groups (1 — with bronchial-pulmonary dysplasia and 2 — with congenital heart defects) were vaccinated with pneumococcal 7-valent conjugated vaccine in 2011 at the expense of municipal budget. Among 116 children from both groups 16 (14%) have had community-acquired pneumonia, which is 22 times higher than in general children population in this region. Dynamic 1-year follow-up showed significant decrease of community-acquired pneumonia prevalence in risk groups: from 16/116 (14%) to 1/75 (1%) (p =0,006). There were no cases of invasive pneumococcal infections among vaccinated children and in 87,5% of them the general morbidity decreased. The frequency of moderate general post-vaccinal reactions was 1,8%, topical reactions — 0,9%. There were no other side effects during post-vaccinal period. Thereafter, the vaccination against pneumococcal infection performed in Novosibirsk in children with risk of fatal complications showed high efficacy and safety of the used vaccine.

детипневмококковая вакцинабронхолегочная дисплазияврожденный порок сердцаchildrenpneumococcal vaccinebronchial-pulmonary dysplasiacongenital heart defectReferencesO’Brien K. L., Wolfson L. I., Henkle E., Henkle E., Deloria-Knoll M., McCall N., Lee E., Mulholland K., Levine O. S., Cherian T. Burden of diseases caused by Streptococcus pneumoniae in children global estimates. Lancet. 2009; 374: 983–902.O’Brien K. L., Wolfson L. I., Henkle E., Henkle E., Deloria-Knoll M., McCall N., Lee E., Mulholland K., Levine O. S., Cherian T. Burden of diseases caused by Streptococcus pneumoniae in children global estimates. Lancet. 2009; 374: 983–902.Sliman KL., Daniels L., Garediner M. Acquisition of Streptococcus pneumoniae and nonspecific morbidity in infants and their families: a cohort study. Pediatr. Infect. Dis. J. 2005; 24: 121–127.Sliman KL., Daniels L., Garediner M. Acquisition of Streptococcus pneumoniae and nonspecific morbidity in infants and their families: a cohort study. Pediatr. Infect. Dis. J. 2005; 24: 121–127.Syriyanen R. K., Auranen K. I., Leino T. M., Kilpi T. M., Makela P. H. Pneumococcal otitis media in relation to pneumococcal nasopharyngeal carriage. Pediatr. Infect. Dis. J. 2005; 24: 1801–1806.Syriyanen R. K., Auranen K. I., Leino T. M., Kilpi T. M., Makela P. H. Pneumococcal otitis media in relation to pneumococcal nasopharyngeal carriage. Pediatr. Infect. Dis. J. 2005; 24: 1801–1806.Mackenzie G. A., Leach A. J., Carapetis J. R., Fisher J., Morris P. S. Epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults: cross-sectional surveys in a population with high rates of pneumococcal disease. BMC Infect. Dis. 2010; 10: 304.Mackenzie G. A., Leach A. J., Carapetis J. R., Fisher J., Morris P. S. Epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults: cross-sectional surveys in a population with high rates of pneumococcal disease. BMC Infect. Dis. 2010; 10: 304.Koukhtinova N. V., Lentze M. J., Schmitt-Grohe S., Schmidt S. M., Jaton K. The role of infections in exacerbation of atopical, nonatopical asthma and recurrent bronchitis in children. Eur. Respir. J. 2004; 24 (Suppl. 48): 273.Koukhtinova N. V., Lentze M. J., Schmitt-Grohe S., Schmidt S. M., Jaton K. The role of infections in exacerbation of atopical, nonatopical asthma and recurrent bronchitis in children. Eur. Respir. J. 2004; 24 (Suppl. 48): 273.Kukhtinova N. V., Krotova S. A., Gavalov S. M. The role of pneumococcal infection in development of respiratory tract infections in children with bronchial asthma and recurrent bronchitis. Voprosi sovremennoi pediatrii — Current Pediatrics. 2011; 10 (2): 22–27.Kukhtinova N. V., Krotova S. A., Gavalov S. M. The role of pneumococcal infection in development of respiratory tract infections in children with bronchial asthma and recurrent bronchitis. Voprosi sovremennoi pediatrii — Current Pediatrics. 2011; 10 (2): 22–27.Pinegina Yu. V. Peculiarities of nosocomial pneumonia clinical course, the level of carriage and resistance of pneumococcus in children. Author’s abstract of a doctoral thesis. Tomsk. 2009. 23 pp.Pinegina Yu. V. Peculiarities of nosocomial pneumonia clinical course, the level of carriage and resistance of pneumococcus in children. Author’s abstract of a doctoral thesis. Tomsk. 2009. 23 pp.Kukhtinova N. V., Kondyurina Ye. G. Epidemiological peculiarities of pneumococcal infections of lower respiratory tract in children with different phenotypes of bronchial asthma and obstructive bronchitis. Ural medical journal. 2011; 07 (85): 93–97.Kukhtinova N. V., Kondyurina Ye. G. Epidemiological peculiarities of pneumococcal infections of lower respiratory tract in children with different phenotypes of bronchial asthma and obstructive bronchitis. Ural medical journal. 2011; 07 (85): 93–97.Harboe Z. B., Thomsen R. W., Riis A., Valentiner-Branth P., Christensen J. J., Lambertsen L., Krogfelt K. A., Konradsen H. B., Benfield T. L. Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study. PLoS Med. 2009; 6 (5): e1000081.Harboe Z. B., Thomsen R. W., Riis A., Valentiner-Branth P., Christensen J. J., Lambertsen L., Krogfelt K. A., Konradsen H. B., Benfield T. L. Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study. PLoS Med. 2009; 6 (5): e1000081.Statement on the care of the child with chronic lung dDisease of infancy and childhood. The Official Statement of the American Thoracic Society. Am. J. Respir. Crit. Care Med. 2003; 168: 356–396.Statement on the care of the child with chronic lung dDisease of infancy and childhood. The Official Statement of the American Thoracic Society. Am. J. Respir. Crit. Care Med. 2003; 168: 356–396.Pravention und Therapie der bronchopulmonalen Dysplasie Fruhgeborener. Leitlinien der Gesellschaft fur Neonatologie und Padiatrische Intensivmedizin und der Deutschen Gesellschaft fur Kinderheilkunde und Jugendmedizin (DGKJ). AWMF-LeitlinienRegister. Nr. 024/014.Pravention und Therapie der bronchopulmonalen Dysplasie Fruhgeborener. Leitlinien der Gesellschaft fur Neonatologie und Padiatrische Intensivmedizin und der Deutschen Gesellschaft fur Kinderheilkunde und Jugendmedizin (DGKJ). AWMF-LeitlinienRegister. Nr. 024/014.Gasior N., David M., Millet V., Reynaud-Gaubert M., Dubus J. C. Adult respiratory sequelae of premature birth. Rev. Mal. Respir. 2011; 28 (10): 1329–1339.Gasior N., David M., Millet V., Reynaud-Gaubert M., Dubus J. C. Adult respiratory sequelae of premature birth. Rev. Mal. Respir. 2011; 28 (10): 1329–1339.Sinelnikov Yu. S., Gorbatykh Yu. N., Gorbatykh A. V., Ivantsov S. M., Strelnikova M. S., Chashchin O. V., Prokhorova D. S., Litasova Ye.Ye. Surgical treatment of coarctation of aorta with hypoplasia of distal part of aortic arch in newborns. Pathology of blood circulation and cardiosurgery. 2011; 3: 9–12.Sinelnikov Yu. S., Gorbatykh Yu. N., Gorbatykh A. V., Ivantsov S. M., Strelnikova M. S., Chashchin O. V., Prokhorova D. S., Litasova Ye.Ye. Surgical treatment of coarctation of aorta with hypoplasia of distal part of aortic arch in newborns. Pathology of blood circulation and cardiosurgery. 2011; 3: 9–12.Khoshnood B., Lelong N., Houyel L., Thieulin A. C., Jouannic J. M., Magnier S., Delezoide A. L., Magny J. F., Rambaud C., Bonnet D., Goffinet F. EPICARD Study Group. Prevalence, timing of diagnosis and mortality of newborns with congenital heart defects: a populationbased study. Heart. 2012; [Epub ahead of print]Khoshnood B., Lelong N., Houyel L., Thieulin A. C., Jouannic J. M., Magnier S., Delezoide A. L., Magny J. F., Rambaud C., Bonnet D., Goffinet F. EPICARD Study Group. Prevalence, timing of diagnosis and mortality of newborns with congenital heart defects: a populationbased study. Heart. 2012; [Epub ahead of print]

The authors declare that there are no conflicts of interest present.