vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v12i2.632vsp-358Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSОпыт применения этанерцепта при ювенильном анкилозирующем спондилоартритеExperience of etanercept treatment in juvenile ankylosing spondyloarthritisФетисоваА. Н.FetisovaA. N.alekatya@ya.ruАлексееваЕ. И.AlexeevaE. I.

Contacts: Alekseyeva Yekaterina Iosifovna, PhD, MD, professor, Head of Rheumatological Department, National Center of Children’s Health, Russian Academy of Medical Sciences, Dean of Pediatric Faculty, I.M. Sechenov First Moscow State Medical University Address: 119991, Moscow, Lomonosovskiy Prospect, 2, bldg. 1, Tel.: (499) 134-02-97, e-mail: alekatya@yandex.ru

alekatya@ya.ruБзароваТ. М.BzarovaT. M.alekatya@ya.ruСлепцоваТ. В.SleptsovaT. V.alekatya@ya.ruНаучный центр здоровья детей РАМН, МоскваРоссияScientific Centre of Children Health, RAMS, Moscow,Russian FederationНаучный центр здоровья детей РАМН, Москва; Первый Московский государственный медицинский университет им. И.М. СеченоваРоссияScientific Centre of Children Health, RAMS, Moscow; I.M. Sechenov First Moscow State Medical University,Russian FederationНаучный центр здоровья детей РАМН, МоскваРоссияScientific Centre of Children Health, RAMS, MoscowRussian Federation201319032013122Вопросы современной педиатрии131138Copyright © Фетисова А.Н., Алексеева Е.И., Бзарова Т.М., Слепцова Т.В., 20132013Фетисова А.Н., Алексеева Е.И., Бзарова Т.М., Слепцова Т.В.Fetisova A.N., Alexeeva E.I., Bzarova T.M., Sleptsova T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/358

Представлен случай тяжелого течения ювенильного анкилозирующего спондилоартрита, характеризующегося быстрым развитием асимметричного полиартикулярного суставного синдрома, сакроилеита, инвалидизацией пациента, низким качеством жизни ребенка и его семьи. Подавить активность патологического процесса удалось благодаря успешному применению растворимого рецептора к фактору некроза опухоли α — этанерцепта. На фоне терапии перестал рецидивировать суставной синдром, восстановилась функция практически во всех пораженных суставах, снизились лабораторные показатели активности воспалительного процесса. Фаза неактивной болезни на фоне лечения этанерцептом была зарегистрирована через 12 нед, ремиссия — через 9 мес лечения.

A history case of severe juvenile ankylosing spondyloarthritis, characterized by rapid development of asymmetric polyarticular syndrome, sacroiliitis, patient’s incapacity and low quality of his and his family life, is discussed in this article. The activity of pathological process was managed to be suppressed due to successful usage of soluble tumor necrosis factor α receptor — etanercept. As a result of treatment the recurrence of articular syndrome was arrested, the function in almost all of the involved joints was recovered, laboratory markers of inflammatory activity decreased. Non-active stage of the disease was established in 12 weeks of etanercept treatment, remission — in 9 months.

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The authors declare that there are no conflicts of interest present.