vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v23i6.2822vsp-3653Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWПоследствия антибиотикотерапии в перинатальном периоде для кишечной микробиоты ребенка раннего возрастаOutcomes of Antibiotic Therapy During Perinatal Period for the Early Age Child’s Intestinal Microbiotahttps://orcid.org/0000-0002-8717-2539БеляеваИ. А.BelyaevaIrina A.

Беляева Ирина Анатольевна - доктор медицинских наук, профессор Российской академии наук, заведующая отделом преконцепционной, антенатальной и неонатальной медицины НИИ педиатрии и охраны здоровья детей; профессор кафедры факультетской педиатрии педиатрического факультета (Пироговский Университет); врач-неонатолог  (Морозовская ДГКБ)

119333, Москва, ул. Фотиевой, д. 10, стр. 1

 

Moscow

irinaneo@mail.ruhttps://orcid.org/0000-0002-2209-7531Намазова-БарановаЛ. С.Namazova-BaranovaLeyla S.

Москва

Moscow

https://orcid.org/0000-0002-6677-2914БомбардироваЕ. П.BombardirovaElena P.

Москва

 Moscow

https://orcid.org/0000-0002-4955-0121ТуртиТ. В.TurtiTatyana V.

Москва

Moscow

ШукенбаеваР. А.ShukenbayevaRegina A.

Москва

Moscow

НИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. Пирогова (Пироговский Университет); ГБУЗ «Морозовская детская городская клиническая больница»РоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Morozovskaya Children’s City HospitalRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. Пирогова (Пироговский Университет)РоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical UniversityRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»РоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryRussian FederationНИИ педиатрии и охраны здоровья детей НКЦ №2 ФГБНУ «РНЦХ им. акад. Б.В. Петровского»; РНИМУ им. Н.И. Пирогова (Пироговский Университет); НИИ организации здравоохранения и медицинского менеджментаРоссияResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical ManagementRussian FederationРНИМУ им. Н.И. Пирогова (Пироговский Университет)РоссияPirogov Russian National Research Medical UniversityRussian Federation202403012025236447455Copyright © Беляева И.А., Намазова-Баранова Л.С., Бомбардирова Е.П., Турти Т.В., Шукенбаева Р.А., 20242024Беляева И.А., Намазова-Баранова Л.С., Бомбардирова Е.П., Турти Т.В., Шукенбаева Р.А.Belyaeva I.A., Namazova-Baranova L.S., Bombardirova E.P., Turti T.V., Shukenbayeva R.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3653

В обзоре литературы приводятся сведения о последствиях антибиотикотерапии (АБТ), воздействию которой ребенок подвергается в перинатальном периоде, в отношении формирования важнейшей системы организма — кишечной микробиоты. Представлены основные характеристики повреждения микробиоты кишечника младенцев при различном времени экспозиции и объеме АБТ, а также особенности влияния антибиотиков на становление кишечной микробиоты у доношенных и недоношенных детей. Изложены современные данные о формировании резистома патобионтов и симбионтов в составе микробиоты кишечника в диаде «мать – дитя» и возможности вертикальной (от матери к ребенку) и горизонтальной (между микроорганизмами) передачи генов антибиотикорезистентности. Охарактеризованы основные стратегии минимизации негативных последствий перинатальной АБТ.

This literature review provides data on antibiotic therapy (AT) consequences that child may be exposed during the perinatal period considering the development of the most crucial body system — intestinal microbiota. The main characteristics of the intestinal microbiota disturbance in infants due to various AT exposure time and volume are presented. Moreover, antibiotics' effects on the intestinal microbiota development in full-term and premature babies are covered. Modern data on the development of pathobionts and symbionts resistome within intestinal microbiota in «mother-child» complex and variants of vertical (from mother to child) and horizontal (between  microorganisms) transmission of antibiotic resistance genes are presented. The major strategies for minimizing the negative consequences of perinatal AT are described

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The authors declare that there are no conflicts of interest present.