vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v12i1.561vsp-372Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCEОБОГАЩЕНИЕ ПРОДУКТОВ ДЕТСКОГО ПИТАНИЯ ПРЕБИОТИКАМИ: ДОСТИЖЕНИЯ И ПРОБЛЕМЫENRICHMENT OF PRODUCTS FOR CHILDREN FOOD WITH PREBIOTICS: ACHIEVEMENTS AND CHALLENGESСафроноваА. И.SafronovaA. I.

Safronova Adilya Ilgizovna, PhD, MD, scientific worker of Laboratory of Children’s Nutrition, Federal State Budget Institution “Scientific Institute of Nutrition”, Russian Academy of Medical Sciences Address: 109240, Moscow, Ustyinskiy pr. 2/14, Tel.: (495) 698-53-63, e-mail: sai1509@yandex.ru

sai1509@yandex.ruКоньИ. Я.Kon'I. Ya.sai1509@yandex.ruГеоргиеваО. В.GeorgievaO. V.sai1509@yandex.ruНИИ питания РАМН, МоскваРоссияScientific Research Institute of Nutrition RAMS, MoscowRussian FederationНИИ питания РАМН, Москва,РоссияScientific Research Institute of Nutrition RAMS, MoscowRussian Federation201303022013121Вопросы современной педиатрии8792Copyright © Сафронова А.И., Конь И.Я., Георгиева О.В., 20132013Сафронова А.И., Конь И.Я., Георгиева О.В.Safronova A.I., Kon' I.Y., Georgieva O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/372

С момента формулирования концепция пребиотиков была поддержана и развита многими исследователями во всем мире. Использование пребиотиков для оптимизации состава кишечной микрофлоры и, таким образом, укрепления здоровья младенцев служит объектом внимания как исследователей, так и педиатров. В сообщении кратко изложены основные данные о классификации и свойствах наиболее распространенных пребиотиков с особым акцентом на инулиноподобных фруктанах и приведены литературные и собственные данные, касающиеся клинической оценки различных пребиотических продуктов.

Since the moment of its formulation, the concept of prebiotics was supported and developed by many researches across the world. The usage of prebiotics for the optimization of the intestinal microflora composition and, therefore, the strengthening of infants health has an increased interest both of scientists and pediatricians. In this article the authors give briefly account on the classification and characteristics of the most common prebiotics, making an emphasis on inulin-type fructans, and show literature and their own data on clinical assessment of different prebiotic products.

пребиотикипитание детейгалактоолигосахаридыинулинолигофруктозаprebioticschildren foodgalactooligosaccharidesoligofructoseReferencesGibson G. R., Roberfroid M. B. Dietary modulation of the human colonic microbiota — introducing the concept of prebiotic. J. Nutrition. 1995; 125: 1401–1412.Gibson G. R., Roberfroid M. B. Dietary modulation of the human colonic microbiota — introducing the concept of prebiotic. J. Nutrition. 1995; 125: 1401–1412.Kunz C., Koletzko B. et al. Nutritional and biochemical properties of human milk, part I. General aspects, proteins and carbohydrates. Clin. Perinatol. 1999; 26: 307–333.Kunz C., Koletzko B. et al. Nutritional and biochemical properties of human milk, part I. General aspects, proteins and carbohydrates. Clin. Perinatol. 1999; 26: 307–333.Kunz C., Baier W. et al. Oligosaccharides in human milk: structural, functional, and metabolic aspects. Ann. Rev. Nutr. 2000; 20: 699–722.Kunz C., Baier W. et al. Oligosaccharides in human milk: structural, functional, and metabolic aspects. Ann. Rev. Nutr. 2000; 20: 699–722.Engfer M. B., Stahl B. et al. Human milk oligoccharides are resistant to enzymatic hydrolyses in the upper gastrointestinal tract. Am. J. Clin. Nutr. 2000; 71: 1589–1596.Engfer M. B., Stahl B. et al. Human milk oligoccharides are resistant to enzymatic hydrolyses in the upper gastrointestinal tract. Am. J. Clin. Nutr. 2000; 71: 1589–1596.Miller J., McVeagh P. Human milk oligoccharides: 130 reasons to breastfeed. Brit. J. Nutr. 1999; 82: 111.Miller J., McVeagh P. Human milk oligoccharides: 130 reasons to breastfeed. Brit. J. Nutr. 1999; 82: 111.Demigne C., Jacobs H., Moundras C. et al. Comparision of native or reformulated chicory fructans, or non-purified chicory, on rat cecal fermentation and mineral metabolism. Eur. J. Nutr. 2008; 47: 366–374.Demigne C., Jacobs H., Moundras C. et al. Comparision of native or reformulated chicory fructans, or non-purified chicory, on rat cecal fermentation and mineral metabolism. Eur. J. Nutr. 2008; 47: 366–374.Roberfroid M., Robertson D. Effect of inulin and oligofructose on health and well-being. Brit. J. Nutr. 2005; 9 (Suppl. 1): 1–27.Roberfroid M., Robertson D. Effect of inulin and oligofructose on health and well-being. Brit. J. Nutr. 2005; 9 (Suppl. 1): 1–27.Roberfroid M. Inulin-type fructans: functional food ingredient. J. Nutr. 2007; 137: 2493–2502.Roberfroid M. Inulin-type fructans: functional food ingredient. J. Nutr. 2007; 137: 2493–2502.Roberfroid M. Prebiotics: the concept revisited. J. Nutr. 2007; 137 (3, 2): 830–837.Roberfroid M. Prebiotics: the concept revisited. J. Nutr. 2007; 137 (3, 2): 830–837.Liong M.-T. Roles of probiotics and prebiotics in colon cancer prevention: postulated mechanisms and in vivo evidence. Int. J. Mol. Sci. 2008; 9 (5): 854–863.Liong M.-T. Roles of probiotics and prebiotics in colon cancer prevention: postulated mechanisms and in vivo evidence. Int. J. Mol. Sci. 2008; 9 (5): 854–863.Griffin I. J., Davila P. M., Abrams S. A. Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes. Brit. J. Nutr. 2002; 87: 187–191.Griffin I. J., Davila P. M., Abrams S. A. Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes. Brit. J. Nutr. 2002; 87: 187–191.van den Heuvel E. G., Muys T., van Dokkum W. et al. Oligofructose stimulates calcium absorption in adolescents. Am. J. Clin. Nutr. 1999; 69: 544–548.van den Heuvel E. G., Muys T., van Dokkum W. et al. Oligofructose stimulates calcium absorption in adolescents. Am. J. Clin. Nutr. 1999; 69: 544–548.Moro G., Minoli I., Mosca M., Jelinek J., Stahl B., Boehm G. Dosage related bifidogenic effects of galacto- and fructooligosaccharides in formula fed term infants. J. Pediatr. Gastroenterol. Nutr. 2002; 34: 291–295.Moro G., Minoli I., Mosca M., Jelinek J., Stahl B., Boehm G. Dosage related bifidogenic effects of galacto- and fructooligosaccharides in formula fed term infants. J. Pediatr. Gastroenterol. Nutr. 2002; 34: 291–295.Savino F., Cresi F., Maccario S., Cavallo F., Dalmasso P., Fanaro S. et al. «Minor» feeding problems during the first month of life: effect of a partially hydrolysed milk formula containing fructo- and galactooligosaccharides. Acta Paediatrica. 2003; 92: 86–90.Savino F., Cresi F., Maccario S., Cavallo F., Dalmasso P., Fanaro S. et al. «Minor» feeding problems during the first month of life: effect of a partially hydrolysed milk formula containing fructo- and galactooligosaccharides. Acta Paediatrica. 2003; 92: 86–90.Boehm G., Fanaro S., Jelinek J., Stahl B., Marini A. Prebiotic concept for infant nutrition. Acta Paediatr. Suppl. 2003; 91 (441): 64–67.Boehm G., Fanaro S., Jelinek J., Stahl B., Marini A. Prebiotic concept for infant nutrition. Acta Paediatr. Suppl. 2003; 91 (441): 64–67.Fanaro S., Boehm G., Garssen J., Knol J., Mosca F., Stahl B., Vigi V. Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Acta Paediatr. Suppl. 2005; 94 (449): 22–26.Fanaro S., Boehm G., Garssen J., Knol J., Mosca F., Stahl B., Vigi V. Galacto-oligosaccharides and long-chain fructo-oligosaccharides as prebiotics in infant formulas: a review. Acta Paediatr. Suppl. 2005; 94 (449): 22–26.Kim S. H., Lee D. H., Meyer D. Supplementation of baby formula with native inuline has a prebiotic effect in formula-fed babies. Asia Pac. J. Clin. Nutr. 2007; 16: 172–177.Kim S. H., Lee D. H., Meyer D. Supplementation of baby formula with native inuline has a prebiotic effect in formula-fed babies. Asia Pac. J. Clin. Nutr. 2007; 16: 172–177.Kon I.Ya., Abramova T. V., Pustograyev N. N., Konovalova L. S., Kiseleva Ye. S. A study of new dried adapted milk formula in nutrition of infants. Questions of practical Pediatrics. 2008; 3 (4): pp. 76–81.Kon I.Ya., Abramova T. V., Pustograyev N. N., Konovalova L. S., Kiseleva Ye. S. A study of new dried adapted milk formula in nutrition of infants. Questions of practical Pediatrics. 2008; 3 (4): pp. 76–81.Kon I.Ya., Abramova T. V., Safronova A. I., Gultikova O. S. Results of multicenter study of clinical efficacy of dried adapted milk formula with dietary fibres in nutrition of infants. Questions of practical Pediatrics. 2010; 5 (2): pp. 29–37.Kon I.Ya., Abramova T. V., Safronova A. I., Gultikova O. S. Results of multicenter study of clinical efficacy of dried adapted milk formula with dietary fibres in nutrition of infants. Questions of practical Pediatrics. 2010; 5 (2): pp. 29–37.Braegger C., Chmielevska A., Desci T., Kolacek S., Mihatsch W., Moreno L. et al. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by ESPGHAN Commitee on Nutrition. J. Pediatr. Gastroenterol. Nutr. 2010.Braegger C., Chmielevska A., Desci T., Kolacek S., Mihatsch W., Moreno L. et al. Supplementation of infant formula with probiotics and/or prebiotics: a systematic review and comment by ESPGHAN Commitee on Nutrition. J. Pediatr. Gastroenterol. Nutr. 2010.Sholtens P., Alles M., van Der Linde E., Knol J. Introduction of solid weaning foods with added prebiotic oligosaccharides affects the composition of the intestinal microflora. J. Pediatr. Gastroenterol. Nutr. 2003; 4 (36): 566.Sholtens P., Alles M., van Der Linde E., Knol J. Introduction of solid weaning foods with added prebiotic oligosaccharides affects the composition of the intestinal microflora. J. Pediatr. Gastroenterol. Nutr. 2003; 4 (36): 566.Sholtens P., Alles M., Bindels J. G., van Der Linde E., Tolboom J., Knol J. Bifidogenic effects of solid weaning foods with added prebiotic oligosaccharides: a randomized controlled clinical trial. J. Pediatr. Gastroenterol. Nutr. 2006; 42 (5): 553–559.Sholtens P., Alles M., Bindels J. G., van Der Linde E., Tolboom J., Knol J. Bifidogenic effects of solid weaning foods with added prebiotic oligosaccharides: a randomized controlled clinical trial. J. Pediatr. Gastroenterol. Nutr. 2006; 42 (5): 553–559.Saavedra J., Tshernia A. Human studies with probiotics and prebiotics: clinical implications. Brit. J. Nutr. 2002; 87 (Suppl. 2): 241–246.Saavedra J., Tshernia A. Human studies with probiotics and prebiotics: clinical implications. Brit. J. Nutr. 2002; 87 (Suppl. 2): 241–246.Firmansyah A., Pramila G., Fassler A., Hashke F., Link-Amster H. Improved humoral immune response to measles vaccine in infants receiving infant cereal with fructooligosaccharides. J. Pediatr. Gastroenterol. Nutr. 2000; Abstract 521.Firmansyah A., Pramila G., Fassler A., Hashke F., Link-Amster H. Improved humoral immune response to measles vaccine in infants receiving infant cereal with fructooligosaccharides. J. Pediatr. Gastroenterol. Nutr. 2000; Abstract 521.Kon I.Ya., Abramova T. V., Georgiyeva O. V. Prebiotics in children’s food products: the study of cereal enriched by prebiotics in nutrition of infants. Questions of children’s dietology. 2008; 6 (1): pp. 66–70.Kon I.Ya., Abramova T. V., Georgiyeva O. V. Prebiotics in children’s food products: the study of cereal enriched by prebiotics in nutrition of infants. Questions of children’s dietology. 2008; 6 (1): pp. 66–70.Kon I.Ya., Safronova A. I., Abramova T. V., Pustograyev N. N., Kurkova V. I. Cereals with inulin in nutrition of infants. Russian bulletin of perinatology and Pediatrics. 2012; 3: pp. 106–110.Kon I.Ya., Safronova A. I., Abramova T. V., Pustograyev N. N., Kurkova V. I. Cereals with inulin in nutrition of infants. Russian bulletin of perinatology and Pediatrics. 2012; 3: pp. 106–110.

The authors declare that there are no conflicts of interest present.